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Nucleosome assembly protein 1-like 4

Nap2, NAP1L4, hNAP2, nucleosome assembly protein 2
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NaP, IL-8, CAN, HAD, MIP
Papers on Nap2
A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro.
Xiao et al., Guangzhou, China. In Mol Cell Neurosci, Jan 2016
Here, we identified a specific NgR1 antagonist peptide (HIYTALV, named NAP2) which promotes neurite regeneration in vitro from a phage display heptapeptide library.
Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome.
Vlachoyiannopoulos et al., Athens, Greece. In J Autoimmun, Dec 2015
Increased plasma levels of CXCL4 may favor this process; therefore we measured plasma levels of CXCL4, a CXCL4 variant (CXCL4L1) and as controls, platelet-derived chemokines CXCL7 (NAP-2) and CCL5 (RANTES), in APS, and disease controls such as patients with systemic lupus erythematosus (SLE) coronary artery disease (CAD) and healthy donors (HDs).
Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates.
Gunnlaugsson et al., Dublin, Ireland. In Dalton Trans, Nov 2015
Linear and circular dichroism (LD and CD) spectroscopy reveal close association of the Ru(bpy)3(2+) core with DNA in the case of the mono-naphthalamide complex, [Ru(bpy)2(bpy-NAP)](2+). Significantly, binding by the second naphthalimide arm in the [Ru(bpy)2(bpy-NAP2)](2+) complex is found to displace the Ru(bpy)3(2+) centre from the DNA backbone.
Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus.
Sun et al., Nanjing, China. In Arthritis Rheumatol, Sep 2015
Cytokine antibody array analysis revealed that leptin and neutrophil-activating peptide 2 (NAP-2) were the 2 factors most significantly elevated in SLE serum compared with normal serum.
Biallelic expression of Tssc4, Nap1l4, Phlda2 and Osbpl5 in adult cattle.
Li et al., Baoding, China. In J Genet, Sep 2015
To increase our understanding of imprinted genes in bovine Cdkn1c/Kcnq1ot1 imprinting cluster, we assessed the imprinting status of four cattle genes (Tssc4,Nap1l4, Phlda2 and Osbpl5) in seven types of tissues: heart, liver, spleen, lung, kidney, skeletal muscle and subcutaneous fat using polymorphism-based sequencing approach.
Amniotic epithelial cells promote wound healing in mice through high epithelialization and engraftment.
Kim et al., Harbin, China. In J Tissue Eng Regen Med, Aug 2015
Real-time PCR showed that the epithelialization growth factors epidermal growth factor (EGF), platelet-derived growth factor (PDGF)-B and chemotactic factors interleukin-8 (IL-8 or CXCL8) and neutrophil-activating protein-2 (NAP-2 or CXCL7) were upregulated in AMEs compared with adipose-derived mesenchymal stem cells (ADMs).
Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion.
Pielen et al., Freiburg, Germany. In Plos One, 2014
LEP (3.4), MMP3 (4.3), MMP9 (3.6), MMP10 (5.4), PPBP (CXCL7 or NAP2) (11.8),
Leukocyte presence does not increase microbicidal activity of Platelet-rich Plasma in vitro.
Filardo et al., Bologna, Italy. In Bmc Microbiol, 2014
MIP-1α, RANTES, GRO-α, IL-8, NAP-2, SDF-1α and IL-6 showed strong microbicidal potential.
RNase MRP RNA and RNase P activity in plants are associated with a Pop1p containing complex.
Schön et al., Leipzig, Germany. In Nucleic Acids Res, 2012
The results provide evidence that in plants, Pop1p is associated with MRP RNAs and with the catalytic subunit of RNase P, either separately or in a single large complex.
Interaction between nucleosome assembly protein 1-like family members.
Rogner et al., Paris, France. In J Mol Biol, 2011
Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones.
Nagata et al., Tsukuba, Japan. In Genes Cells, 2010
The biochemical properties of two human NAP1-like proteins, hNAP1L1 and hNAP1L4, were characterized.
Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.
Moore et al., London, United Kingdom. In Plos One, 2009
Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.
Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection.
Lam et al., Vancouver, Canada. In J Clin Oncol, 2009
RESULTS: Connective tissue-activating peptide III (CTAP III)/ neutrophil activating protein-2 (NAP-2) and haptoglobin were identified to be significantly higher in venous than in arterial blood.
Platelet chemokines in vascular disease.
Ley et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, 2008
The megakaryocyte CXCL7 gene product is proteolytically cleaved into the strong neutrophil chemoattractant, NAP-2, which has also been implicated in repair cell homing to vascular lesions.
Nucleosome formation with the testis-specific histone H3 variant, H3t, by human nucleosome assembly proteins in vitro.
Kurumizaka et al., Tokyo, Japan. In Nucleic Acids Res, 2008
Human Nap2 promotes nucleosome assembly with H3t/H4.
Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration.
Hui, United States. In Neurochem Res, 2007
In fact, our laboratory found two novel neuron-specific aminopeptidases: NAP and NAP-2.
Radiolabeled chemotactic cytokines: new agents for scintigraphic imaging of infection and inflammation.
Oyen et al., Nijmegen, Netherlands. In Q J Nucl Med, 2003
The characteristics of a series of cytokines (IL-1, IL-2), chemokines (IL-8, PF-4, MCP-1, NAP-2), complement factors (C5a, C5adR), chemotactic peptides (fMLF) and other chemotactic factors (LTB4) are described.
The beta-thromboglobulins and platelet factor 4: blood platelet-derived CXC chemokines with divergent roles in early neutrophil regulation.
Flad et al., Germany. In J Leukoc Biol, 2000
Herein we review our work on early neutrophil regulation by PF-4, the beta-thromboglobulin neutrophil-activating peptide 2 (NAP-2) and its major precursor connective tissue-activating peptide III (CTAP-III).
Antigens involved in heparin-induced thrombocytopenia.
Amiral, Gennevilliers, France. In Semin Hematol, 1999
These antibodies frequently react either with interleukin-8 (IL-8) or with neutrophil-activating peptide 2 (NAP-2).
Molecular evolution of the human interleukin-8 receptor gene cluster.
Murphy et al., Bethesda, United States. In Nat Genet, 1992
Two human IL-8 receptors, IL8RA and IL8RB, are known from cDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GRO alpha and NAP-2.
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