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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nanog homeobox

This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Sox2, CAN, KLF4, OCT, HAD
Papers using Nanog antibodies
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.
Akagi Tadayuki, In PLoS ONE, 2006
... The Rabbit anti-Nanog polyclonal antibody was obtained from Bethyl Laboratories (Montgomery, TX, USA) ...
Human embryonic stem cell lines with genetic disorders
Lavon Neta et al., In In Vitro Cellular & Developmental Biology. Animal, 2004
... anti-human OCT-3/4, mouse IgM anti-human TRA-1-60 (Santa Cruz Biotechnology Inc, Santa Cruz, CA) and rabbit anti-NANOG (Abcam Inc, Cambridge, MA) ...
Papers on Nanog
High glucose-induced reactive oxygen species generation promotes stemness in human adipose-derived stem cells.
Young et al., Taipei, Taiwan. In Cytotherapy, Feb 2016
Although dASCs or HG-treated nASCs exhibited decreased proliferation, enhanced expression of the pluripotent markers Sox-2, Oct-4, and Nanog was observed.
Induced pluripotent stem cells with six reprogramming factors from Prairie Vole, which is an animal model for social behaviors.
Fukuda et al., In Cell Transplant, Feb 2016
We constructed a polycistronic reprogramming vector, which included six reprograming factors (Oct3/4, Sox2, Klf4, c-myc, Lin28, and Nanog).
Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.
Li et al., Mudanjiang, China. In Int J Oncol, Feb 2016
accompanied by the apparently elevated ALDH activity and the upregulation of the stem cell markers OCT-4, Nanog, and SOX2 compared with parental (P<0.01).
WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells.
Zhang et al., Shanghai, China. In Int J Oncol, Feb 2016
Moreover, in-depth analysis revealed that PP caused inhibition of WNT pathway activity and stemness regulator expression including NANOG, SOX2 and OCT4, which were inherently upregulated in the BCSCs as compared with the bulk of cells within the tumor.
Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming.
Liu et al., Guangzhou, China. In Cell Metab, Feb 2016
The reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression that is associated with decreases in the methylation status of the Nanog promoter through Tet2 occupancy.
NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
Machida et al., Los Angeles, United States. In Cell Metab, Feb 2016
Stem cell markers, including NANOG, have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear.
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
UNASSIGNED: Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise role is yet unclear.
Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells.
Dehghani et al., Mashhad, Iran. In Tumour Biol, Jan 2016
In this review, we focus on some transcription factors such as Nanog, NF-κB, and Bmi-1 that cooperate with CXCR4/CXCL12 for the maintenance of stemness and induction of metastasis behavior in cancer stem cells.
Stem cell transcription factor NANOG in cancers - is eternal youth a curse?
Cheung et al., Hong Kong, Hong Kong. In Expert Opin Ther Targets, Jan 2016
NANOG is one of the key factors for maintaining the self-renewal ability and pluripotency of stem cells, including cancer stem cells.
Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.
Walsh et al., New York City, United States. In Cell Stem Cell, Jan 2016
Consistently, Zfp217 depletion compromises ESC self-renewal and somatic cell reprogramming, globally increases m(6)A RNA levels, and enhances m(6)A modification of the Nanog, Sox2, Klf4, and c-Myc mRNAs, promoting their degradation.
The Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer.
Sarkar et al., Detroit, United States. In Adv Exp Med Biol, Dec 2015
Investigation of CSCs in determining their role in tumor recurrence and drug-resistance relied heavily on the use of specific markers present in CSCs, including CD133, ALDH, ABCG2, and Nanog.
Apocynin and Diphenyleneiodonium Induce Oxidative Stress and Modulate PI3K/Akt and MAPK/Erk Activity in Mouse Embryonic Stem Cells.
Pacherník et al., Brno, Czech Republic. In Oxid Med Cell Longev, Dec 2015
Further, we revealed that apocynin inhibits PI3K/Akt pathway with its downstream transcriptional factor Nanog. Opposite to this, apocynin augmented activity of canonical Wnt signaling.
The role of NANOG transcriptional factor in the development of malignant phenotype of cancer cells.
Bednarek et al., Katowice, Poland. In Cancer Biol Ther, Dec 2015
UNASSIGNED: NANOG is a transcription factor that is involved in the self-renewal of embryonic stem cells (ES) and is a critical factor for the maintenance of the undifferentiated state of pluripotent cells.
Network plasticity of pluripotency transcription factors in embryonic stem cells.
Schroeder et al., München, Germany. In Nat Cell Biol, Oct 2015
We use reporter mouse ESC lines allowing non-invasive quantification of Nanog or Oct4 protein levels and continuous long-term single-cell tracking and quantification over many generations to reveal diverse TF protein expression dynamics.
Pluripotency Genes and Their Functions in the Normal and Aberrant Breast and Brain.
Kakulas et al., Perth, Australia. In Int J Mol Sci, 2014
They share certain characteristics with ESCs, such as an inherent capacity to self-renew and differentiate into cells of the three germ layers, properties that are regulated by master pluripotency transcription factors (TFs) OCT4 (octamer-binding transcription factor 4), SOX2 (sex determining region Y-box 2), and homeobox protein NANOG.
Human Nanog pseudogene8 promotes the proliferation of gastrointestinal cancer cells.
Akashi et al., Fukuoka, Japan. In Exp Cell Res, 2012
Nanog pseudogene8 is involved in GI cancer development in a fraction of patients, in whom it presumably acts by supporting cancer stem cell proliferation
Fibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors.
Terada et al., Gainesville, United States. In J Biol Chem, 2012
FGFR2 induces rapid but reversible Nanog repression within ES cells.
Cyclic mechanical strain maintains Nanog expression through PI3K/Akt signaling in mouse embryonic stem cells.
Ushida et al., Tokyo, Japan. In Exp Cell Res, 2012
The findings imply that mechanical force plays a role in regulating Nanog expression in ES cells through the actin cytoskeleton-PI3K-Akt signaling.
Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells.
Hung et al., Taipei, Taiwan. In Mol Cell, 2012
Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells
Forced expression of Nanog in human bone marrow-derived endothelial cells activates other six pluripotent genes.
Covas et al., Ribeirão Preto, Brazil. In Cell Reprogram, 2012
The introduction of Nanog was sufficient to alter the expression of key genes of the pluripotent pathway.
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