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NAD kinase

NAD kinase, NADK
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Phosphodiesterase, HAD, fibrillin-1
Papers on NAD kinase
Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.
Kawai et al., Uji, Japan. In Biochem Biophys Res Commun, Jan 2016
Human mitochondrial NAD kinase is a crucial enzyme responsible for the synthesis of mitochondrial NADP(+).
Effect of Polyhydroxybutyrate (PHB) storage on L-arginine production in recombinant Corynebacterium crenatum using coenzyme regulation.
Xu et al., Wuxi, China. In Microb Cell Fact, Dec 2015
NAD kinase could upregulate the NADPH concentration in the bacteria.
Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy.
Bertino et al., Mongolia. In Mol Pharmacol, Oct 2015
NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH.
Overexpression of ZWF1 and POS5 improves carotenoid biosynthesis in recombinant Saccharomyces cerevisiae.
Zhan et al., Wuxi, China. In Lett Appl Microbiol, Oct 2015
When POS5 was overexpressed (Sc-EYBIPH+I), NAD kinase activity increased by 5·5-fold, the transcription level of crtE, crtYB and crtI increased obviously, the lycopene and β-carotene yield increased to 2·50 ± 0·11 and 0·53 ± 0·03 mg l(-1) respectively.
MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase.
Zhang, Detroit, United States. In J Cell Physiol, Aug 2015
The NAD kinase (NADK) is the sole NADP biosynthetic enzyme.
Involvement of multiple cellular pathways in regulating resistance to tamoxifen in BIK-suppressed MCF-7 cells.
Arenas-Aranda et al., Mexico. In Tumour Biol, Aug 2015
Molecules identified in the drug resistance pathway were 14-3-3z or YWHAZ, WEE1, PRKACA, NADK, and HSP90AA 1. Further, genes involved in cell cycle control, apoptosis, and cell proliferation were also found differentially expressed in these cells.
Enhanced production of poly-3-hydroxybutyrate by Escherichia coli over-expressing multiple copies of NAD kinase integrated in the host genome.
Tan et al., Beijing, China. In Biotechnol Lett, Jun 2015
OBJECTIVES: With the help of attB-attP recombination technique, multiple copies of yfjB gene encoding the NAD kinase of Escherichia coli were inserted into the host chromosome to promote NADPH-dependent poly-3-hydroxybutyrate (PHB) production.
Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data.
Hajek et al., Brno, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, Jun 2015
RESULTS: Comparison of high-risk plasma cells vs extramedullary plasma cells revealed 4 significantly deregulated genes (CKS1B, CTBS, NADK, YWHAZ); moreover, comparison of extramedullary plasma cells vs extramedullary tumors revealed significant differences in 9 out of 15 genes.
Comparative proteome analysis of global effect of POS5 and zwf-ppnK overexpression in L-isoleucine producing Corynebacterium glutamicum ssp. lactofermentum.
Li et al., Wuxi, China. In Biotechnol Lett, May 2015
Overexpression of the Saccharomyces cerevisiae-derived NADH kinase gene (POS5) and the endogenous glucose-6-phosphate dehydrogenase and NAD kinase genes (zwf-ppnK) in JHI3-156 increased Ile production by 26 and 31 %, respectively.
NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.
Heart et al., New London, United States. In Am J Physiol Endocrinol Metab, 2012
The data suggested that NADK kinase regulates intracellular redox and affects insulin secretion and oxidative defense in the pancreatic beta cell.
NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme.
Murata et al., Uji, Japan. In Mol Cell Biochem, 2011
Using purified human NAD kinase, we revealed a sigmoidal kinetic behavior toward ATP and the inhibitory effects of NADPH and NADH
[Progress in polyphosphate and related metabolizing enzymes].
Xie et al., Chongqing, China. In Sheng Li Ke Xue Jin Zhan, 2011
Enzymes with activities requiring polyP, such as endopolyphosphatase, glucokinase, NAD kinase, AMP phosphotransferase are outlined too.
Metabolic networks to combat oxidative stress in Pseudomonas fluorescens.
Appanna et al., Greater Sudbury, Canada. In Antonie Van Leeuwenhoek, 2011
Central to this shift in the metabolic production of the pyridine nucleotides is the increase in NAD kinase with the concomitant decrease in NADP phosphatase.
Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets.
Xie et al., Chongqing, China. In J Cell Physiol, 2011
Three enzymes pivotal to the key reactions of NAD(P) biosynthesis are shared by almost all organisms, that is, NMN/NaMN adenylyltransferase (NMN/NaMNAT), NAD synthetase (NADS), and NAD kinase (NADK).
NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK) inhibitors: chemistry and potential therapeutic applications.
Cappellacci et al., Italy. In Curr Med Chem, 2010
Herein we focus on two of them: NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK).
NAD kinase levels control the NADPH concentration in human cells.
Ziegler et al., Bergen, Norway. In J Biol Chem, 2007
NAD kinase levels control the NADPH concentration in human cells
Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary.
Means et al., In Nature, 1981
One intracellular target for Ca2+ is calmodulin, a ubiquitous intracellular Ca2+ receptor that has been shown to modulate many cellular functions, including cyclic nucleotide and glycogen metabolism, protein phosphorylation, microtubule assembly and disassembly, a Ca2+ flux, and the activities of NAD kinase, tryptophan 5' monooxidase and phospholipase A2 (see refs 2-5 for reviews).
Calmodulin activates NAD kinase of sea urchin eggs: an early event of fertilization.
Cheung et al., In Cell, 1981
NAD kinase, one of the first enzymes activated after fertilization of sea urchin eggs, is regulated by Ca2+ and calmodulin in vitro.
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