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NLR family, pyrin domain containing 1

This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ros, V1a, CAN, PrP, ACID
Papers using NAC antibodies
Biochemical characteristics of clinical and environmental isolates of Burkholderia pseudomallei
Steinmetz Ivo et al., In Frontiers in Microbiology, 1995
... -acetyl-cysteine (NAC), aminoguanidine (AG), and colchicine (Col) were from Sigma Aldrich (Taufkirchen, Germany) ...
Papers on NAC
What Future Role Might N-Acetyl-Cysteine Have in the Treatment of Obsessive Compulsive and Grooming Disorders?: A Systematic Review.
Giaroli et al., London, United Kingdom. In J Clin Psychopharmacol, Feb 2016
The glutamatergic system has been implicated in the etiology of obsessive-compulsive spectrum disorders, and it has been postulated that n-acetyl-cysteine (NAC) could have a therapeutic effect on these conditions through its actions on the glutamatergic system and the reduction of oxidative stress.
Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: Therapeutic intervention with combinatorial therapy of N-acetyl cysteine and apocynin.
Singla et al., Chandīgarh, India. In Mitochondrion, Feb 2016
NAC with apocynin was also found to be effective in reducing the redundant activity of NADPH oxidase in renal tissue of hyperoxaluric rats.
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Gu et al., Beijing, China. In J Mol Cell Cardiol, Feb 2016
The antioxidant NAC, apocynin and MnTBAP had the similar protective effects in the development of PAH.
Functional Regulation of PI3K-Associated Signaling in the Accumbens by Binge Alcohol Drinking in Male but not Female Mice.
Finn et al., Portland, United States. In Neuropharmacology, Feb 2016
UNASSIGNED: It is well established that binge alcohol consumption produces alterations in Group 1 metabotropic glutamate receptors (mGlus) and related signaling cascades in the nucleus accumbens (NAC) of adult male mice, but female and adolescent mice have not been examined.
Gene expression regulation in roots under drought.
Szarejko et al., Katowice, Poland. In J Exp Bot, Jan 2016
In particular, the role of several transcription factor (TF) families, including DREB, AP2/ERF, NAC, bZIP, MYC, CAMTA, Alfin-like and Q-type ZFP, in the regulation of root response to drought are highlighted.
Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.
Schneider et al., New Haven, United States. In Clin Breast Cancer, Jan 2016
PATIENTS AND METHODS: Archival tumor tissue from 3 disease types (IBC treated with neoadjuvant chemotherapy [NAC], n = 45; invasive ductal carcinoma [IDC] treated with NAC [n = 24; 'treated IDC'; and untreated IDC [n = 27; 'untreated IDC']) was analyzed for the expression of biomarkers phospho-S6 (pS6) (mTOR), phospho-JAK2 (pJAK2), pSTAT3, interleukin (IL)-6, CD68 (monocytes, macrophages), and CD163 (TAMs).
Oncological safety of prophylactic breast surgery: skin-sparing and nipple-sparing versus total mastectomy.
Koppert et al., Rotterdam, Netherlands. In Gland Surg, Dec 2015
To allow for immediate breast reconstruction the skin envelope is left in situ with or without the nipple-areola complex (NAC).
The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum.
Deuerling et al., Konstanz, Germany. In Science, May 2015
We found that in the model organism Caenorhabditis elegans, correct cotranslational endoplasmic reticulum (ER) transport required the suppressor activity of the nascent polypeptide-associated complex (NAC).
Pharmacological treatment of idiopathic pulmonary fibrosis - preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine.
Kaarteenaho et al., Helsinki, Finland. In Eur Clin Respir J, 2014
This review article summarizes the published investigations on the preclinical studies of three novel IPF drugs, namely pirfenidone, nintedanib, and N-acetylcysteine (NAC).
The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms.
Hasselbalch et al., Roskilde, Denmark. In Mediators Inflamm, 2014
In regard to the potent efficacy of the ROS-scavenger N-acetyl-cysteine (NAC) in decreasing ROS levels, it is intriguing to consider if NAC treatment might benefit patients with MPN.
Inhibition of myeloperoxidase activity have impact on the formation of DNA double-strand breaks induced by etoposide in HL-60 cell line.
Wąsik et al., Kraków, Poland. In Folia Med Cracov, 2014
Studies were carried out on HL-60 cell line, which were preincubated with the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH), or antioxidant N-acetyl-L-cysteine (NAC), followed by incubation at different concentrations of etoposide (1-10 mM) for 4 hours.
Contribution of NAC transcription factors to plant adaptation to land.
Demura et al., Ikoma, Japan. In Science, 2014
The NAC transcription factors regulate the differentiation of these cells in vascular plants.
NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice.
Koller et al., Chapel Hill, United States. In J Immunol, 2012
our findings show that assembly of the NLRP1 inflammasome is sufficient to initiate pyroptosis
Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity.
Gough et al., United States. In J Biol Chem, 2012
Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity.
Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma.
Söderkvist et al., Linköping, Sweden. In Pigment Cell Melanoma Res, 2012
NLRP3/NLRP1 polymorphisms are associated with melanoma susceptibility
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Arteaga et al., Nashville, United States. In Nat Med, 2012
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~30% of patients with breast cancer.
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus.
Sandrin-Garcia et al., São Paulo, Brazil. In Autoimmunity, 2012
results demonstrated that NLRP1 rs2670660 SNP and the NLRP1 rs12150220-rs2670660 A-G haplotype were associated with systemic lupus erythematosus in our study population, and in particular with the development of nephritis, rash and arthritis
Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.
Duarte et al., São Paulo, Brazil. In J Acquir Immune Defic Syndr, 2012
Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects. 2 polymorphisms in NLRP3 and IL1B were significantly associated to the HIV-1 infection.
Magnetic resonance imaging response monitoring of breast cancer during neoadjuvant chemotherapy: relevance of breast cancer subtype.
Gilhuijs et al., Amsterdam, Netherlands. In J Clin Oncol, 2011
PURPOSE: To evaluate the relevance of breast cancer subtypes for magnetic resonance imaging (MRI) markers for monitoring of therapy response during neoadjuvant chemotherapy (NAC).
Molecular control of kinetochore-microtubule dynamics and chromosome oscillations.
Meraldi et al., Zürich, Switzerland. In Nat Cell Biol, 2010
Here we show that centromere protein (CENP)-H, a subunit of the CENP-A nucleosome-associated and CENP-A distal complexes (CENP-A NAC/CAD), is essential for this coordination, because kinetochores lacking CENP-H establish bioriented attachments but fail to generate regular oscillations, as a result of an uncontrolled rate of microtubule plus-end turnover.
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