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Nebulin-related anchoring protein

N-RAP, Utp22
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RAP, Actin, nebulin, LIM, alpha-Actinin
Papers on N-RAP
Roles of Nebulin Family Members in the Heart.
Chen et al., Milano, Italy. In Circ J, 2014
The members of the nebulin protein family, including nebulin, nebulette, LASP-1, LASP-2, and N-RAP, contain various numbers of nebulin repeats and bind to actin, but are otherwise heterogeneous with regard to size, expression pattern, and function.
Crossreactive autoantibodies directed against cutaneous and joint antigens are present in psoriatic arthritis.
Puccetti et al., Genova, Italy. In Plos One, 2013
Interestingly the PsA peptide shares homology with the nebulin-related anchoring protein (N-RAP), a protein localized in the enthesis (point of insertion of a tendon or ligament to the bone), which represents the first affected site during early PsA.
An RNA-binding complex involved in ribosome biogenesis contains a protein with homology to tRNA CCA-adding enzyme.
Ye et al., Beijing, China. In Plos Biol, 2013
Utp22 and Rrp7, two interacting proteins with no recognizable domain, are components of the 90S preribosome or the small subunit processome that conducts early processing of 18S rRNA.
Biocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers for skin tissue engineering.
Sethuraman et al., Thanjāvūr, India. In J Biomed Nanotechnol, 2013
The expression of genes associated with T lymphocyte activation (HLA-DRB, thymosin beta 10 (h-Tim)) and IL-2 mediated lymphocyte activation genes (h-Tim, Tumour Rejection Antigen (TRA 1), nRap 2) were investigated in human lymphocyte cultured on PHBV nanofibers.
Patient-specific protein aggregates in myofibrillar myopathies: laser microdissection and differential proteomics for identification of plaque components.
Hanisch et al., München, Germany. In Proteomics, 2012
Dependent on the MFM causing mutation, different sets of proteins were revealed as genuine (accumulated) plaque components in independent technical replicates: (i) αB-crystallin, desmin, filamin A/C, myotilin, PRAF3, RTN2, SQSTM, XIRP1, and XIRP2 (patient with defined MFM mutation distinct from FHL1) or (ii) desmin, FHL1, filamin A/C, KBTBD10, NRAP, SQSTM, RL40, XIRP1, and XIRP2 (patient with FHL1 mutation).
Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p.
Mangroo et al., Guelph, Canada. In Biochem Cell Biol, 2012
It is possible that Nrap/Nol6, the mammalian orthologue of Utp22p, plays a role in channelling aminoacyl-tRNA to the nuclear tRNA export receptor exportin-t.
Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p.
Mangroo et al., Guelph, Canada. In Biochem Cell Biol, 2012
It is possible that Nrap/Nol6, the mammalian orthologue of Utp22p, plays a role in channelling aminoacyl-tRNA to the nuclear tRNA export receptor exportin-t.
The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice.
Gridley et al., West Scarborough, United States. In Genesis, 2012
Nrarp-deficient embryos and mice exhibit genetic background-dependent defects of the axial skeleton. In Nrarp mutant embryos, the posterior somite compartment was expanded.
Cardiac-specific NRAP overexpression causes right ventricular dysfunction in mice.
Horowits et al., Bethesda, United States. In Exp Cell Res, 2011
Results show that chronic NRAP overexpression in the mouse leads to right ventricular cardiomyopathy by 10 months of age.
Scaffolds and chaperones in myofibril assembly: putting the striations in striated muscle.
Horowits et al., United States. In Biophys Rev, 2011
Here, we review the evidence that N-RAP, a LIM domain and nebulin repeat protein, scaffolds assembly of actin and α-actinin into I-Z-I structures in the first steps of assembly; that the heat shock chaperone proteins Hsp90 & Hsc70 cooperate with UNC-45 to direct the folding of muscle myosin and its assembly into thick filaments; and that the kelch repeat protein Krp1 promotes lateral fusion of premyofibril structures to form mature striated myofibrils.
The Nebulin family: an actin support group.
Gregorio et al., Tucson, United States. In Trends Cell Biol, 2011
Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of cytoskeletal structures, and expressed in different tissues.
Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma.
Xiong et al., Shanghai, China. In Bmc Syst Biol, 2009
We identified 4 cis-expression quantitative trait locus (eQTL): TP53, EGFR, NF1 and PIK3C2G; 262 trans eQTL and 26 trans miRNA eQTL for somatic mutation; 2 cis-eQTL: NRAP and EGFR; 409 trans- eQTL and 27 trans- miRNA eQTL for lost of heterozygosity (LOH) mutation.
Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury.
Stelzner et al., Syracuse, United States. In Bmc Neurosci, 2009
In the few genes that were up-regulated (Actb, Atf3, Frs2, Hspb1, Nrap, Stat1) post-axotomy, the expression for all but one was down-regulated by 2-weeks post-injury.
Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.
Ginalski et al., Warsaw, Poland. In Nucleic Acids Res, 2009
These families include hundreds of previously uncharacterized and various poorly annotated proteins such as Fukutin/LICD, NFAT, FAM46, Mab-21 and NRAP.
Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1.
Aballay et al., Durham, United States. In Plos Genet, 2009
A genetic screen for negative regulators of innate immunity in Caenorhabditis elegans led to the identification of a mutation in NOL-6, a nucleolar RNA-associated protein (NRAP), which is involved in ribosome biogenesis and conserved across eukaryotic organisms.
Structure of the amphioxus nebulin gene and evolution of the nebulin family genes.
Kimura et al., Chiba, Japan. In Gene, 2009
These results indicated that the amphioxus nebulin gene had a unified structure among nebulin, nebulette, lasp-1 and N-RAP of vertebrates, and that these nebulin family genes diverged from the amphioxus nebulin gene during the course of vertebrate evolution.
Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle.
Fananapazir et al., Bethesda, United States. In Cell Motil Cytoskeleton, 2003
Highly conserved and exclusively expressed in cardiac and skeletal muscle. Candidate cause for cardiac and skeletal myopathies
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