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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Myosin VA

myosin V, myosin Va, GS1, GS-I, MYO5A
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, GS2, STEP, V1a
Papers using myosin V antibodies
The alpha-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation
Lefebvre Jean-Claude et al., In Breast Cancer Research, 1995
... / isolectin B4 (FITC-GS-I-B4), which recognizes a terminal galactosyl residue in an α linkage, was purchased from EY Laboratories (San Matteo, CA, USA) ...
Papers on myosin V
How Dynein Moves Along Microtubules.
Vale et al., San Francisco, United States. In Trends Biochem Sci, Jan 2016
Here, we summarize the structural and motile properties of dynein and highlight features that distinguish this motor from kinesin-1 and myosin V, two well-studied transport motors.
Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis.
Carter et al., Paris, France. In J Cell Sci, Jan 2016
Myosin Va (MyoVa) is recruited to WPBs by a Rab27A-MyRIP complex and is thought to be the prime mediator of actin binding, however, direct MyRIP-actin interactions can also occur.
Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue.
Kern et al., Colorado, Brazil. In Physiol Genomics, Jan 2016
This analysis produced ADAM22, MYO5A, LOX and GM2A as predicted gene targets of these microRNAs.
Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V.
Yengo et al., Columbus, United States. In Proc Natl Acad Sci U S A, Dec 2015
We have developed a FRET system in myosin V that uses three donor-acceptor pairs to examine the kinetics of lever arm swing during the recovery and power stroke phases of the ATPase cycle.
Computational model of polarized actin cables and cytokinetic actin ring formation in budding yeast.
Vavylonis et al., Bethlehem, United States. In Cytoskeleton (hoboken), Oct 2015
Increasing the affinity of actin filaments for the bud neck together with reduced myosin V pulling promotes the formation of a bundle of antiparallel filaments at the bud neck, which we suggest as a model for the assembly of actin filaments to the contractile ring.
Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments.
Sivaramakrishnan et al., Ann Arbor, United States. In Nat Nanotechnol, Aug 2015
Using both dimeric myosin V- and myosin VI-labelled nanotubes, we find that neither myosin density nor spacing has a significant effect on the gliding speed of actin filaments.
Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation.
Weijer et al., Dresden, Germany. In Nat Cell Biol, Apr 2015
Use of class specific myosin inhibitors and gene-specific knockdown shows that apical contraction and intercalation are myosin II dependent and also reveal critical roles for myosin I and myosin V family members in the assembly of junctional myosin II cables.
Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica.
Kundu et al., Calcutta, India. In Sci Rep, 2014
Ammonia assimilation in the leaves takes place by the enzyme glutamine synthetase (GS) which is present in the cytosol (GS1) and chloroplast (GS2).
Flexural Stiffness of Myosin Va Subdomains as Measured from Tethered Particle Motion.
Ali et al., Burlington, United States. In J Biophys, 2014
Myosin Va (MyoVa) is a processive molecular motor involved in intracellular cargo transport on the actin cytoskeleton.
Cargo recognition and cargo-mediated regulation of unconventional myosins.
Zhang et al., Hong Kong, Hong Kong. In Acc Chem Res, 2014
Such a cargo-mediated dimerization mechanism has also been observed in other myosins including myosin-V and myosin-VIIa.
Cytosolic glutamine synthetase: a target for improvement of crop nitrogen use efficiency?
Schjoerring et al., Frederiksberg, Denmark. In Trends Plant Sci, 2014
Overexpression of the cytosolic enzyme glutamine synthetase 1 (GS1) has been investigated in numerous cases with the goal of improving crop nitrogen use efficiency.
Molecular handoffs in nitrergic neurotransmission.
Chaudhury, Boston, United States. In Front Med (lausanne), 2013
It has been recently reported that motor proteins like myosin Va play important role in transcytosis of nNOS.
[Hypomelanoses transmitted from generation to generation].
Wrześniok et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2013
These disorders are represented by oculocutaneous albinism, Hermansky-Pudlak syndrome, Chediak-Higashi syndrome, Griscelli syndrome, Menkes syndrome and phenylketonuria, and are caused by different mutations of the following genes: TYR, P, TRP1, MATP, HPS, CHS, MYO5A, RAB27A, MLPH, ATP7A and PAH.
Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Li et al., Beijing, China. In J Biol Chem, 2012
Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells.
Gerke et al., Münster, Germany. In Traffic, 2011
A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF.
Myosin5a tail associates directly with Rab3A-containing compartments in neurons.
Langford et al., United States. In J Biol Chem, 2011
Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles
Myosin Va is required for P body but not stress granule formation.
McCaffrey et al., Cork, Ireland. In J Biol Chem, 2011
Myosin Va is required for P body but not stress granule formation.
Neuronal transport: myosins pull the ER.
Bradke et al., In Nat Cell Biol, 2011
Myosin Va is now shown to function as a point-to-point transporter that pulls the endoplasmic reticulum (ER) into dendritic spines, with important consequences for dendritic development and cerebellar motor learning
Video imaging of walking myosin V by high-speed atomic force microscopy.
Ando et al., Kanazawa, Japan. In Nature, 2010
The dynamic behaviour of myosin V molecules translocating along actin filaments has been mainly studied by optical microscopy.
Myosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteins.
Baines et al., Ithaca, United States. In J Virol, 2010
Myo5a is activated in cells during HSV-1 infection to help transport virion- and glycoprotein-laden vesicles from the TGN, through the cortical actin, to the plasma membrane.
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