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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


myoferlin, MYOF, FER1L3
Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: dysferlin, fibrillin-1, CAN, FeS, Actin
Papers on myoferlin
Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer.
Peulen et al., Liège, Belgium. In Int J Cancer, Mar 2016
Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis.
Expression of nuclear factor of activated T cells (NFAT) and downstream muscle-specific proteins in ground squirrel skeletal and heart muscle during hibernation.
Storey et al., Ottawa, Canada. In Mol Cell Biochem, Jan 2016
We propose that calcium signalling proteins [calcineurin (Cn), calmodulin (CaM), and calpain], the nuclear factor of activated T cell (NFAT) family of transcription factors, and the NFAT targets myoferlin and myomaker contribute significantly to adaptations taking place in skeletal and cardiac muscle during hibernation.
Ferlins show tissue-specific expression and segregate as plasma membrane/late endosomal or trans-Golgi/recycling ferlins.
Cooper et al., Sydney, Australia. In Traffic, Jan 2016
Dysferlin, myoferlin, and Fer1L6 are plasma membrane (PM) ferlins, whereas otoferlin and Fer1L5 localize predominantly to intracellular compartments.
Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells.
Kniss et al., Columbus, United States. In Am J Physiol Cell Physiol, May 2015
Our recent work has revealed that myoferlin (MYOF) mediates breast tumor cell motility and invasive phenotype.
Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis.
Economou et al., Irákleion, Greece. In Clin Proteomics, 2014
We also observed that the proteins GSTP1, PLS3, MYOF, HSD17B12, PRDX2, APCS, PLA2G2A SERPINH1/HSP47 and MVP, show distinct synthesis levels, characteristic for OA or control chondrocytes.
Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair.
Cooper et al., Sydney, Australia. In Mol Biol Cell, 2014
Of importance, we reveal that myoferlin and otoferlin are also cleaved enzymatically to release similar C-terminal modules, bearing two C2 domains and a transmembrane domain.
sdf1 Expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish.
Blazar et al., Minneapolis, United States. In Stem Cells, 2014
Global proteomic studies performed by two-dimensional liquid chromatography and tandem mass spectrometry revealed a high degree of similarity to human MSC (hMSC) and discovery of novel markers (CD99, CD151, and MYOF) that were previously unknown to be expressed by hMSC.
[Effect and mechanism of jianpi qinghua recipe on renal functions of adriamycin-induced nephropathic rats from the angle of inhibiting renal fibrosis].
He et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, 2014
OBJECTIVE: To explore the effect of Jianpi Qinghua Recipe (JQR) on renal functions of adriamycin-induced focal segmental glomerular sclerosis (FSGS) rats from the angle of activating fibroblasts to myofibroblast (MyoF).
EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development.
Demonbreun et al., Chicago, United States. In Dev Biol, 2014
It was previously shown that EHD proteins bind directly to the C2 domains in myoferlin, a protein that regulates myoblast fusion.
Dysferlin and myoferlin regulate transverse tubule formation and glycerol sensitivity.
McNally et al., Chicago, United States. In Am J Pathol, 2014
We bred Dysf mice to mice lacking myoferlin (MKO) to generate mice lacking both myoferlin and dysferlin (FER).
Unveiling transcription factor regulation and differential co-expression genes in Duchenne muscular dystrophy.
Huang et al., Xuzhou, China. In Diagn Pathol, 2013
Among the DEGs which shared TFs with DMD, six genes were co-expressed with DMD, including ATP1A2, C1QB, MYOF, SAT1, TRIP10, and IFI6.
Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers.
Yang et al., Rochester, United States. In Bmc Med Genomics, 2013
Ten genes (EGFR, TP53, KRAS, RPS6KB2, ATXN2, DHX9, PTPN13, SP1, SPTAN1 and MYOF) had recurrent mutations and these mutations were highly correlated with pathway deregulation and patient survival.
Loss of myoferlin redirects breast cancer cell motility towards collective migration.
Kniss et al., Columbus, United States. In Plos One, 2013
We previously discovered that myoferlin (MYOF) is overexpressed in breast cancer cells and depletion of MYOF results in a mesenchymal to epithelial transition (MET) and reduced invasion through extracellular matrix (ECM).
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.
Bernad et al., Madrid, Spain. In J Tissue Eng Regen Med, 2013
Several, including CD26, myoferlin and podocalyxin-like protein 1 (PODXL), have been previously described in other stem-cell systems.
Mechanistic modeling of the effects of myoferlin on tumor cell invasion.
Friedman et al., Columbus, United States. In Proc Natl Acad Sci U S A, 2012
MYOF plays a previously unrecognized role in cancer cell invasion.
Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo.
Bernatchez et al., Vancouver, Canada. In Vascul Pharmacol, 2011
Myoferlin gene knockdown not only decreases lipid vesicle fusion in EC but also attenuates Vascular Endothelial Growth Factor (VEGF) Receptor-2 (VEGFR-2) expression.
Ferlin proteins in myoblast fusion and muscle growth.
McNally et al., Chicago, United States. In Curr Top Dev Biol, 2010
Myoferlin is highly expressed in myoblasts that undergoing fusion, and the absence of myoferlin leads to impaired myoblast fusion.
Myoferlin regulation by NFAT in muscle injury, regeneration and repair.
McNally et al., Chicago, United States. In J Cell Sci, 2010
increased expression in myofibres after muscle injury and in a mouse model of muscular dystrophy
Myoferlin is required for insulin-like growth factor response and muscle growth.
McNally et al., Chicago, United States. In Faseb J, 2010
IGF1 receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1
Myoferlin is critical for endocytosis in endothelial cells.
Sessa et al., Vancouver, Canada. In Am J Physiol Cell Physiol, 2009
These data describe a new role for myoferlin in receptor-dependent endocytosis and an overlapping role for myoferlin-dynamin 2-caveolin 1 protein complexes in membrane fusion and fission events.
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