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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Myocilin, trabecular meshwork inducible glucocorticoid response

myocilin, MYOC, TIGR, GLC1A
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, POLYMERASE
Papers using myocilin antibodies
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction
Yu Fu-Shin, In PLoS ONE, 2003
... A plasmid vector pTRE-MYOC-EGFP-INS-rtTA-IRES-hyg-pcDNA3.1z
Localization of two homologous Arabidopsis kinesin-related proteins in the phragmoplast
Meier Iris et al., In BMC Evolutionary Biology, 2003
... AGI locus numbers from TAIR are used as sequence IDs for Arabidopsis, TIGR sequence IDs are used for rice ...
VISTA : visualizing global DNA sequence alignments of arbitrary length
Nakamura Toshiki et al., In BMC Genomics, 1999
... TIGR rice locus IDs for the TaEST-LUGs extracted ...
Grima-Pettenati Jacqueline et al., In BMC Plant Biology, 1998
... TAIR7 peptides, TIGR Rice genome annotation, NCBI grapevine), as well as the GO and PFAM annotation terms and IDs allocated to the first ...
Papers on myocilin
Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma.
Dickey et al., Tampa, United States. In Exp Eye Res, Mar 2016
Mutations in the MYOC gene cause hereditary primary open-angle glaucoma (POAG) by promoting the abnormal amyloidosis of the myocilin protein in the endoplasmic reticulum (ER), leading to ER stress-induced TM cell death.
Candidate genes involved in the susceptibility of primary open angle glaucoma.
Kaur et al., New Delhi, India. In Gene, Mar 2016
However, the role of only three underlying genes Myocilin (MYOC), Optineurin (OPTN) and WD repeat Domain 36, (WDR36) is well established.
Low-dose rotenone exposure induces early senescence leading to late apoptotic signaling cascade in human trabecular meshwork (HTM) cell line: An in vitro glaucoma model.
Ghosh et al., New Delhi, India. In Cell Biol Int, Jan 2016
An accumulation of cytoplasmic myocilin, IL-6, and MMP-9 at 72 h of exposure supported glaucomatous induction.
Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshwork.
Clark et al., Fort Worth, United States. In Exp Eye Res, Dec 2015
Ocular hypertension has successfully been induced by adenovirus 5 mediated delivery of mutant MYOC, bioactivated TGFβ2, SFRP1, DKK1, GREM1, and CD44.
CYP1B1 and MYOC Mutations in Vietnamese Primary Congenital Glaucoma Patients.
Vithana et al., Singapore, Singapore. In J Glaucoma, Dec 2015
The 3 implicated genes are cytochrome P450 family I subfamily B polypeptide 1 (CYP1B1), latent transforming growth factor β-binding protein 2 (LTBP2), and myocilin (MYOC).
A Unique Case of JOAG With Lamellar Ichthyosis With Rickets: A Case Report and Review of the Literature.
Singh et al., New Delhi, India. In J Glaucoma, Nov 2015
Screening of JOAG-associated genes (MYOC, NTF4, WDR36, and CYP1B1) and ichthyosis-associated gene (TGM1) was performed by the direct PCR-sequencing method.
Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.
Rao et al., Durham, United States. In Invest Ophthalmol Vis Sci, Aug 2015
PURPOSE: To explore the role of inducible focal adhesion (FA) protein Hic-5 in actin cytoskeletal reorganization, FA formation, fibrogenic activity, and expression of myocilin in trabecular meshwork (TM) cells.
Detection of the MicroRNA expression profile in skeletal muscles of burn trauma at the early stage in rats.
Hongjie et al., Beijing, China. In Ulus Travma Acil Cerrahi Derg, Jul 2015
Glaucoma in iran and contributions of studies in iran to the understanding of the etiology of glaucoma.
Elahi et al., Tehrān, Iran. In J Ophthalmic Vis Res, 2015
Screening of JOAG patients showed that an approximately equal fraction of the patients harbor CYP1B1 and (myocilin) MYOC mutations; MYOC is a well-known adult onset glaucoma causing gene.
Advances in glaucoma genetics.
Mabuchi et al., Japan. In Prog Brain Res, 2014
Familial linkage studies for POAG have been performed and identified causative POAG disease genes (e.g., MYOC, OPTN, and WDR36).
Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells.
Fini et al., Los Angeles, United States. In Mol Vis, 2014
MYOC mutations have been causally linked to high-tension forms of primary open angle glaucoma (POAG).
Ten SNPs of PAX6, Lumican, and MYOC genes are not associated with high myopia in Han Chinese.
Fu et al., Harbin, China. In Ophthalmic Genet, 2012
Our results confirm that the PAX6, Lumican, and MYOC genes were not associated with high myopia in the Han Chinese in Northeastern China.
Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain.
Stamer et al., Tucson, United States. In Biochemistry, 2012
A coiled-coil segment of myocilin is identified with homology to human Q-SNARE proteins.
Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
Tomarev et al., Bethesda, United States. In J Biol Chem, 2012
We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin associated protein complex.
Cystatin a, a potential common link for mutant myocilin causative glaucoma.
Borrás et al., Chapel Hill, United States. In Plos One, 2011
findings provide a new molecular understanding of the mechanisms of MYOC-causative glaucoma and reveal CSTA, a serum biomarker for cancer, as a potential biomarker and drug for the treatment of MYOC-induced glaucoma
Comprehensive analysis of myocilin variants in east Indian POAG patients.
Ray et al., Calcutta, India. In Mol Vis, 2011
MYOC mutations were found to account for 3% of POAG cases in east Indian POAG cohort (n=765), and Gln48His is the most common defect.
Physiogenomic resources for rat models of heart, lung and blood disorders.
Lee et al., Rockville, United States. In Nat Genet, 2006
The TIGR rodent expression web-based resource (TREX) contains over 2,200 microarray hybridizations, involving over 800 animals from 18 different rat strains.
Gene index analysis of the human genome estimates approximately 120,000 genes.
Quackenbush et al., Rockville, United States. In Nat Genet, 2000
We have developed a highly refined and rigorously tested protocol for cleaning, clustering and assembling EST sequences to produce high-fidelity consensus sequences for the represented genes (F.L. et al., manuscript submitted) and used this to create the TIGR Gene Indices-databases of expressed genes for human, mouse, rat and other species (
Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)
Stone et al., Iowa City, United States. In N Engl J Med, 1998
Mutations causing glaucoma have been identified in the chromosome 1 open-angle glaucoma gene (GLC1A), which encodes a 57-kd protein known as myocilin.
Identification of a gene that causes primary open angle glaucoma.
Sheffield et al., Iowa City, United States. In Science, 1997
Analyses of sequence tagged site (STS) content and haplotype sharing between families affected with chromosome 1q-linked open angle glaucoma (GLC1A) were used to prioritize candidate genes for mutation screening.
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