Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke.
Tübingen, Germany. In Proc Natl Acad Sci U S A, Sep 2015
Cerebral microbleeds and larger hemorrhages developed upon postnatal and adult depletion of either SRF or its cofactors Myocardin Related Transcription Factor (MRTF-A/-B), revealing essential requirements of ongoing SRF/MRTF activity for maintenance of cerebral small vessel integrity.
Myocardin in biology and disease.
Rochester, United States. In J Biomed Res, 2015
Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum response factor (SRF) over cis elements known as CArG boxes found near a number of genes encoding for contractile, ion channel, cytoskeletal, and calcium handling proteins.
A MicroRNA-Transcription Factor Blueprint for Early Atrial Arrhythmogenic Remodeling.
A Coruña, Spain. In Biomed Res Int, 2014
MicroRNA (miRNA) transcriptome and expression of candidate transcription factors (TFs) with potential roles in arrhythmogenesis, such as Pitx2, Tbx5, and myocardin (Myocd), were analyzed by microarray, qRT-PCR, and Western blotting in left atrial (LA) samples from pigs with transitory AF established by right atrial tachypacing.
Myocardin and smooth muscle differentiation.
Calgary, Canada. In Arch Biochem Biophys, 2014
Myocardin (MYOCD), a co-transcriptional activator of serum response factor (SRF), stimulates the expression of smooth muscle (SM) genes and inhibits the cell cycle.
The imbalance of vascular molecules in Alzheimer's disease.
Rochester, United States. In J Alzheimers Dis, 2011
In particular, the vascular-specific transcription factors MEOX2, MYOCD, and SRF, genetic risk factor APOE4, transport proteins LRP1 and RAGE, and circulating molecules such as sLRP1, homocysteine, and albumin are discussed.
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.
Rochester, United States. In Curr Alzheimer Res, 2007
In addition, we have identified two vascularly restricted genes, GAX (growth arrest-specific homeobox), which controls LRP1 expression in brain capillaries and brain angiogenesis, and MYOCD (myocardin), which controls contractility of cerebral arterial smooth muscle cells and influences cerebral blood flow.