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Musashi homolog 1

Musashi-1, MSI1, Musashi
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: nestin, CAN, Sox2, Msi2, HAD
Papers using Musashi-1 antibodies
Assessing differentiation status of human embryonic stem cells noninvasively using Raman microspectroscopy
Johnson J D et al., In Cell Death & Disease, 2009
... Overexpression constructs for human MSI1-GFP and GFP control plasmids were purchased from OriGene.
Quantitative expression of Oct3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
Okano Hideyuki et al., In Molecular Brain, 1999
... Msi1-ffLuc transgenic mice ...
Papers on Musashi-1
MSI1 functions in a HDAC complex to fine-tune ABA signaling.
Hennig et al., Uppsala, Sweden. In Plant Cell, Jan 2016
UNASSIGNED: MSI1 belongs to a family of histone-binding WD40-repeat proteins.
The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.
Lengner et al., Beijing, China. In Cell Rep, Jan 2016
In contrast to the hematopoietic system, colorectal cancers can express both Msi family members, MSI1 and MSI2.
Prognostic significance of the Musashi-2 (MSI2) gene in childhood acute lymphoblastic leukemia.
Tang et al., In Neoplasma, Dec 2015
The prognostic value of the Musashi-2 (MSI2) gene has not yet been studied in childhood acute lymphoblastic leukemia (ALL).
Irradiation of primary human gliomas triggers dynamic and aggressive survival responses involving microvesicle signaling.
Limoli et al., Irvine, United States. In Environ Mol Mutagen, Dec 2015
Radiation-induced changes were exacerbated under chronic as compared to acute irradiation paradigms and promoted cellular reprogramming through enhanced expression of key transcription factors and regulators involved in differentiation and pluripotency (SOX2, POU3F2, SALL2, OLIG2, NANOG, POU5F1v1, MSI1).
Musashi Signaling in Stem Cells and Cancer.
Reya et al., In Annu Rev Cell Dev Biol, Dec 2015
Musashi, a family of RNA binding proteins discovered originally in Drosophila and named after the iconic samurai, Miyamoto Musashi, has emerged as a key signal that confers and protects the stem cell state across organisms.
miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma.
Zhang et al., Beijing, China. In Tumour Biol, Dec 2015
Mechanistically, we demonstrated that the oncogenic properties of miR-761 in ovarian cancer were mediated in part by regulating MSI1 expression.
Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.
Reya et al., San Diego, United States. In Cell Stem Cell, Sep 2015
Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML.
RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.
McLaughlin et al., Newcastle, Australia. In Asian J Androl, Jul 2015
We emphasize the historical role of the Musashi family of RBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian Musashi proteins, Musashi-1 and Musashi-2, with a primary focus on our findings in spermatogenesis.
Clinical implications of intestinal stem cell markers in colorectal cancer.
Troelsen et al., Denmark. In Clin Colorectal Cancer, Jun 2015
This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC.
RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma.
Vogel et al., New York City, United States. In Mol Cells, 2014
In this review, we discuss a number of RNA binding proteins, including Musashi1 (MSI1), DEAD (Asp-Glu-Ala-Asp) box helicase 3 X-linked (DDX3X), DDX31, and cell division cycle and apoptosis regulator 1 (CCAR1), which play potentially critical roles in the growth and/or maintenance of medulloblastoma.
Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.
Stetak et al., Basel, Switzerland. In Cell, 2014
Here, we report that musashi (msi-1) is necessary for time-dependent memory loss in C. elegans.
Specificity factors in cytoplasmic polyadenylation.
de Moor et al., Denver, United States. In Wiley Interdiscip Rev Rna, 2013
In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1).
The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells.
Penalva et al., San Antonio, United States. In Mol Cancer Res, 2012
Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells.
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
Okano et al., Tokyo, Japan. In Plos One, 2011
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
Sequential expression of putative stem cell markers in gastric carcinogenesis.
Salto-Tellez et al., Singapore, Singapore. In Br J Cancer, 2011
CD44 and Musashi-1 are frequently expressed in both premalignant gastric lesions and invasive gastric cancer, whereas CD133 expression is restricted mainly to neoplastic tissues.
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.
Massagué et al., New York City, United States. In Nat Med, 2011
TNC enhances the expression of stem cell signaling components, musashi homolog 1 (MSI1) and leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5).
Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes.
Johnson et al., Vancouver, Canada. In Cell Death Dis, 2010
Overexpression of MSI1 was sufficient to increase Hes1, stimulate proliferation, inhibit apoptosis and reduce insulin expression, whereas Msi1 knockdown had the converse effects on proliferation and insulin expression.
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Reya et al., Durham, United States. In Nature, 2010
Here we have used mouse models of CML to show that disease progression is regulated by the Musashi-Numb signalling axis.
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Daley et al., Boston, United States. In Nat Med, 2010
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood.
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Jiang et al., Changsha, China. In Cancer Biomark, 2009
Our study suggested that Msi-1 and/or ALDH1 expression might be closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.
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