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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Multiple PDZ domain protein

may play a role in G-protein coupled, 5-HT2C receptor-activated phosphoinositide-linked second messenger signaling [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Numb, CAN, Ubiquitin, V1a, ACID
Papers on MUPP1
The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response.
Hassel et al., Baltimore, United States. In Int J Mol Sci, Dec 2015
We also describe here the interaction of RNase-L with the E3 ubiquitin ligase and scaffolding protein, ligand of nump protein X (LNX), a regulator of tight junction proteins.
Gene polymorphisms and oral cancer risk in tobacco habitués.
Saranath et al., Mumbai, India. In Tumour Biol, Dec 2015
The SNPs rs2124437 (RASGRP3), rs1335022 (GRIK2), rs4512367 (PREX2), rs4748011 (CCDC3), and rs1435218 (LNX1) were analyzed in 500 histopathologically confirmed oral cancers and 500 healthy controls with a minimum of 10 years of tobacco usage.
Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.
Kreek et al., New York City, United States. In Cns Neurosci Ther, Nov 2015
SNP rs3915568 in NTSR1, which encodes neurotensin receptor, and SNP rs1389752 in MPDZ, which encodes the multiple PDZ domain protein, were previously associated with heroin addiction or alcohol addiction, respectively.
Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination.
Sivaraman et al., Singapore, Singapore. In Oncotarget, Nov 2015
LNX (Ligand of Numb Protein-X) proteins, LNX1 and LNX2, are RING- and PDZ-based E3-ubiquitin ligases known to interact with Numb.
Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas.
Dawid et al., Taejŏn, South Korea. In Proc Natl Acad Sci U S A, Nov 2015
The gene encoding the E3 ubiquitin ligase Ligand of Numb protein-X (Lnx)2a is expressed in the ventral-anterior pancreatic bud of zebrafish embryos in addition to its expression in the brain.
PDZRN4 acts as a suppressor of cell proliferation in human liver cancer cell lines.
Han et al., Shanghai, China. In Cell Biochem Funct, Oct 2015
Recently, some reports show that Ligand of Numb Protein-X 1 (LNX1) could be a suppressor gene in gliomas, while our current research has firstly shown that PDZ domain containing ring finger 4 (PDZRN4), another member of LNX family, could also be a potential suppressor in hepatocellular carcinoma (HCC).
Biochemical Large-Scale Interaction Analysis of Murine Olfactory Receptors and Associated Signaling Proteins with Post-Synaptic Density 95, Drosophila Discs Large, Zona-Occludens 1 (PDZ) Domains.
Osterloh et al., Bochum, Germany. In Mol Cell Proteomics, Aug 2015
This system includes the 13 individual PDZ domains of the multiple PDZ domain protein 1 (MUPP1; the largest PDZ protein), a broad range of murine olfactory receptors (a multifaceted gene cluster within the family of GPCRs), and associated olfactory signaling proteins.
CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.
Momoi et al., Ōtawara, Japan. In J Neurochem, Aug 2015
CASPR2 forms a complex with receptors via interaction with multiple PDZ domain protein 1 (MUPP1).
Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population.
Wang et al., Qingdao, China. In Ophthalmic Genet, Jun 2015
SNPs rs4954218 (Near RAB3GAP1 (5')), rs4894535 (FNDC3B), rs2956540 (LOX), rs3735520 (Near HGF (5')), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A1), rs2721051 (Near FOXO1 (3')), rs9938149 (BANP-ZNF469) and rs6050307 (VSX1) were assessed for their association with KC.
Biochemical and structural characterization of MUPP1-PDZ4 domain from Mus musculus.
Liu et al., Shenzhen, China. In Acta Biochim Biophys Sin (shanghai), Mar 2015
Multi-PDZ-domain protein 1 (MUPP1), as a scaffold protein, contains 13 PDZ domains and plays an important role in cytoskeletal organization, cell polarity, and cell proliferation.
Function and cancer genomics of FAT family genes (review).
Katoh, Tokyo, Japan. In Int J Oncol, 2012
FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane‑associated guanylate kinase MPP5/PALS1.
Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence.
Biernacka et al., Rochester, United States. In Addict Biol, 2012
The data indicates potential association between variation in mpdz NMDA dependent AMPA trafficking and alcohol dependence.
The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever.
Ghigo et al., Marseille, France. In Fems Immunol Med Microbiol, 2012
The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever.
The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain.
Nagy et al., Winnipeg, Canada. In Eur J Neurosci, 2012
both AF6 and MUPP1 are associated with Cx36-containing interneuronal gap junctions that form electrical synapses in adult rodent brain
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.
Mottola et al., Napoli, Italy. In J Cell Sci, 2011
LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis
Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models.
Buck et al., Portland, United States. In Alcohol Clin Exp Res, 2011
Analyses of neuronal activation associated with alcohol withdrawal and site-directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi-PDZ domain protein, MPDZ, with 5-HT(2C) receptors and/or NR2B.
Biochemical and computational analysis of LNX1 interacting proteins.
McGlade et al., Toronto, Canada. In Plos One, 2010
identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold.
NG2 cells: Properties, progeny and origin.
Nishiyama et al., Mainz, Germany. In Brain Res Rev, 2010
The C-terminal PDZ-binding motif of the NG2 protein binds several PDZ proteins including Mupp1, Syntenin and the Glutamate Receptor Interacting Protein (GRIP).
Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like.
Dawid et al., Bethesda, United States. In Nat Cell Biol, 2009
LNX (ligand of Numb protein-X) is a RING finger and four PDZ domain-containing E3 ubiquitin ligase.
How do kidney cells adapt to survive in hypertonic inner medulla?
Berl, Aurora, United States. In Trans Am Clin Climatol Assoc, 2008
Multi PDZ protein 1 (MUPP1), a PDZ scaffolding protein, targets Claudin 4 to the tight junction.
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