GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Mucin 1, cell surface associated
MUC1, S-1, KL-6
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] (from
NCBI)
Top mentioned proteins:
CAN, HAD, MUC2, CD45, MUC5AC
Papers using
MUC1
antibodies
MUC1 expression in tumor cells regulates transcription of proinflammatory cytokines by forming a complex with NF-{kappa}B p65 and binding to cytokine promoters: importance of the extracellular domain
Supplier
In Oncoimmunology, 2010
... MUC1 transgenic mice were originally purchased ...
Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides
Supplier
In Breast Cancer Research : BCR, 2005
... MMT mice were generated by breeding MUC1 transgenic (MUC1.Tg) mice with polyomavirus ...
Papers on
MUC1
Generation of transgenic cattle expressing human β-defensin-3 as an approach to reducing susceptibility to Mycobacterim bovis infection.
New
China. In Febs J, Feb 2016
We first generated alveolar epithelial cells (AECs) expressing HBD3 under the control of the bovine MUC1 promoter, and confirmed that these cells secreted HBD3 and possessed anti-mycobacterial capacity.
The role of TF- and Tn-antigens in breast cancer metastasis.
Review
New
München, Germany. In Histol Histopathol, Feb 2016
It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation.
Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release.
New
Impact
Columbus, United States. In Nat Nanotechnol, Feb 2016
DNPs functionalized with the MUC1 aptamer and doxorubicin can target cancer cells and can be used to image and monitor drug release in real time.
TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial.
New
Impact
Strasbourg, France. In Lancet Oncol, Jan 2016
BACKGROUND: MUC1 is a tumour-associated antigen expressed by many solid tumours, including non-small-cell lung cancer.
Mucin 1-mediated chemo-resistance in lung cancer cells.
New
Seoul, South Korea. In Oncogenesis, Dec 2015
Importantly, the levels of oncoproteins phosphoinositide-3 kinase/Akt, mucin 1 cytoplasmic domain (MUC1-C) and β-catenin were also significantly elevated in A549/PTX.
Prognostic Significance of Mucin Antigen MUC1 in Various Human Epithelial Cancers: A Meta-Analysis.
Review
New
Beijing, China. In Medicine (baltimore), Dec 2015
Accumulating evidence indicates that mucin antigen MUC1 plays a fundamental role in the initiation and progression of several types of epithelial carcinomas.
Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review.
Review
New
Hangzhou, China. In Onco Targets Ther, Dec 2015
Molecular markers, including vimentin, napsin A, phosphorylated c-Met, cytoplasmic maspin, Notch-1, MUC1, and tumoral CD10, may have higher expression in MPPAC than other subtypes; conversely, markers such as MUC4 and surfactant apoprotein A have lower expression in MPPAC.
MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.
New
Scottsdale, United States. In Plos One, Dec 2015
UNASSIGNED: It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors.
Breast cancer resistance protein (BCRP)-containing circulating microvesicles contribute to chemoresistance in breast cancer.
New
Wuxi, China. In Oncol Lett, Dec 2015
Interestingly, the results also demonstrated that BCRP was co-expressed with MUC1, which is frequently expressed in breast cancer and is exported via EVs, and both BCRP and MUC1 were up-regulated after chemotherapy.
Polymorphisms in mucin genes in the development of gastric cancer.
Review
New
Baotou, China. In World J Gastrointest Oncol, Dec 2015
Normal gastric mucosa shows expression of MUC1, MUC5AC and MUC6 that is specific to cell type.
[Huikangling Tablet Intervened Peripheral Blood Micrometastasis of Differentiated Thyroid Carcinoma].
New
In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
Peripheral micrometastatic cytokeratin 19 (CK19) and polymorphic epithelial mucin1 (MUC1) were detected by FCM at week 4 and 12.
Loss-of-function variants in ATM confer risk of gastric cancer.
New
Impact
Reykjavík, Iceland. In Nat Genet, Aug 2015
Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1.
[Immunotherapy for the Prevention and Treatment of Breast Cancer].
Review
In Klin Onkol, 2014
The assumption is based on the results of several antitumor vaccine trials targeted against HER2, MUC1, CEA and mammaglobin-A, as well as immune checkpoint inhibitors (e.g.
Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial.
Impact
Edmonton, Canada. In Lancet Oncol, 2014
Our aim was to investigate whether the MUC1 antigen-specific cancer immunotherapy tecemotide improves survival in patients with stage III unresectable non-small-cell lung cancer when given as maintenance therapy after chemoradiation.
The development of synthetic antitumour vaccines from mucin glycopeptide antigens.
Review
Impact
Mainz, Germany. In Chem Soc Rev, 2013
Glycopeptide structures of the tandem repeat sequence of mucin MUC1 of epithelial tumour cells constitute the most promising tumour-associated antigens.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
GeneRIF
Omaha, United States. In Proc Natl Acad Sci U S A, 2012
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Pinopodes, leukemia inhibitory factor, integrin-β3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss.
GeneRIF
Shanghai, China. In Fertil Steril, 2012
Mucin-1 expression is statisically significantly reduced in women with recurrent pregnancy loss.
Characterization of a novel weak interaction between MUC1 and Src-SH3 using nuclear magnetic resonance spectroscopy.
GeneRIF
Edmonton, Canada. In Biochem Biophys Res Commun, 2012
The binding characteristics outlined here suggest that the interaction between Src-SH3 and MUC1-CD represents a novel weak electrostatic interaction of the type which is increasingly recognized as important in transient and dynamic protein complexes required for cell migration and signal transduction.
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.
GeneRIF
San Diego, United States. In Plos One, 2011
EGFR and Src activity contribute to carcinoma cell invasion and metastasis mediated by integrin alphavbeta5 in part by promoting proteolytic cleavage of MUC1 .
Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis.
GeneRIF
Sapporo, Japan. In J Transl Med, 2011
The molecular structural variants of KL-6/MUC1 and its leakage behavior affect serum levels of KL-6 in sarcoidosis.
