Leptin signalling pathways in hypothalamic neurons.
Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
Architecture of human mTOR complex 1.
Zürich, Switzerland. In Science, Feb 2016
Dysregulation of mammalian TOR (mTOR) signaling is implicated in pathologies that include diabetes, cancer, and neurodegeneration.
Impact of dehulling and germination on nutrients, antinutrients, and antioxidant properties in horsegram.
Almora, India. In J Food Sci Technol, Jan 2016
principal component analysis revealed that in case of dehulled samples; TN, polyphenols, DPPH and ABTS radical inhibition, TSS, total antioxidant, OA, protein, FRAP value, Ca and Zn had positive correlation among themselves while in case of germinated samples, protein, oil absorption capacity, FRAP value, OA, total flavonoids, DPPH radical inhibition, Ca and Cu had positive correlation among themselves.
[Chronic rejection : Differences and similarities in various solid organ transplants].
Hannover, Germany. In Internist (berl), Jan 2016
Due to limited therapeutic options, prevention is of utmost importance (administration of mTOR inhibitors and minimizing cardiovascular risk factors).The mid- and long-term survival rates after liver transplantation have hardly changed in recent decades, which is an indication of the difficulty in diagnosing chronic graft dysfunction.
PI3K/Akt/mTOR inhibitors in breast cancer.
Singapore, Singapore. In Cancer Biol Med, Dec 2015
Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in breast cancer.
Signaling crosstalk between the mTOR complexes.
More papers using
Southampton, United Kingdom. In Translation (austin), 2013
mTOR is a protein kinase which integrates a variety of environmental and intracellular stimuli to positively regulate many anabolic processes of the cell, including protein synthesis.
TSC2 deficiency increases PTEN via HIF1alpha
In PLoS ONE, 2008
... (Ser-65) 4EBP-1, phospho-GSK3β, GSK3β, phospho-tuberin (Thr 1462), tuberin, phospho-PRAS40 (Thr 246), PRAS40, phospho-mTOR (Ser-2448) and mTOR antibodies were purchased from Cell Signaling, Boston, MA ... Generation of a conditional disruption of the Tsc2 gene
In Nature neuroscience, 2006
... phospho-TSC2 (T1462), Rheb, phospho-S6K1 (T389), total S6K1, phospho-S6 (S235/236), total S6, phospho-Akt (S473), phospho-4E-BP1 (T37/46), phospho-mTOR (S2481) (Cell Signaling), TSC2, EphA4, ephrin-A2, ephrin-A5, ... Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
In PLoS ONE, 2005
... (Ser-473 and Thr-308), phospho-S6 kinase (Thr-389), phospho-tuberin (Thr-1462), phospho-mTOR (Ser-2448), phospho-p65 (Ser-536), Akt, S6 kinase, mTOR and tuberin were purchased from Cell Signaling, Boston, MA ... Cellular targets of gefitinib.
In PLoS ONE, 2004
... (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR ...