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Myotubularin related protein 4

MTMR4, myotubularin related protein 4, FYVE-DSP2
Top mentioned proteins: Epidermal Growth Factor, STEP, Ubiquitin, EEA1, Nedd4
Papers on MTMR4
Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.
Gingras et al., Toronto, Canada. In Mol Cell Proteomics, Apr 2015
The results reveal a number of potential signaling contexts for this family of enzymes, including an intriguing, novel role for myotubularin-related protein 3 and myotubularin-related protein 4 in the regulation of abscission, the final step of mitosis in which the membrane bridge remaining between two daughter cells is cleaved.
Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4.
Heo et al., Seoul, South Korea. In Acta Crystallogr Sect F Struct Biol Commun, 2014
In this study, the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method.
Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.
Tang et al., Beijing, China. In J Biol Chem, 2013
Herein we demonstrated that myotubularin-related protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DUSP), preferentially associated with and dephosphorylated the activated R-Smads in cytoplasm, which is a critical checkpoint in BMP signal transduction.
Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping.
Kadarmideen et al., Frederiksberg, Denmark. In Plos One, 2012
Synapse genes (GABRR2, PPP1R9B, SYT1, GABRR1, CADPS2, DLGAP2 and GOPC), dephosphorylation genes (PPM1E, DAPP1, PTPN18, PTPRZ1, PTPN4, MTMR4 and RNGTT) and positive regulation of peptide secretion genes (GHRH, NNAT and TCF7L2) were highly significantly associated with feeding behavior traits.
The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion.
Stenmark et al., Oslo, Norway. In Traffic, 2012
This screen identified several potential regulators of EGF degradation, including HRS (used as positive control), PX kinase, MTMR4 and Phafin2/PLEKHF2.
Novel genes as primary triggers for polygenic hypertension.
Deng et al., Montréal, Canada. In J Hypertens, 2012
C10QTL1 is one of five genes, namely Benzodiazepine receptor associated protein 1, Loc689764, myotubularin related protein 4, protein phosphatase 1E, PP2C domain containing and ring finger protein 43.
The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice.
Batt et al., Toronto, Canada. In Plos One, 2011
These effects are not mediated by the Nedd4-1 substrates MTMR4, FGFR1 and Notch-1.
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes.
Mitchell et al., Australia. In J Cell Sci, 2010
MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking.
MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes.
Tang et al., Beijing, China. In J Biol Chem, 2010
MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes
Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study.
Vohl et al., Canada. In Mol Genet Metab, 2009
Three positional candidates were identified in this region according to their implication in the phosphoinositide (PI) cycle: the myotubularin-related protein 4 (MTMR4), the phospholipase C, delta 3 (PLCD3), and the diacylglycerol kinase E (DGKE) genes.
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.
Batt et al., Toronto, Canada. In Biochem J, 2009
Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes.
Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.
Clague et al., Liverpool, United Kingdom. In J Cell Sci, 2006
We have confirmed all previously reported combinations and identified novel heteromeric interactions: MTMR8 with MTMR9, and MTMR3 with MTMR4, the first such combination of enzymatically active MTMs.
Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications.
Swierniak et al., Gliwice, Poland. In Cancer Res, 2005
It included the following 19 genes: DPP4, GJB3, ST14, SERPINA1, LRP4, MET, EVA1, SPUVE, LGALS3, HBB, MKRN2, MRC2, IGSF1, KIAA0830, RXRG, P4HA2, CDH3, IL13RA1, and MTMR4, and correctly discriminated 17 of 18 additional PTC/normal thyroid samples and all 16 samples published in a previous microarray study.
Development of microsatellite markers and comparative mapping for bovine chromosome 19.
Warren et al., Madison, United States. In Anim Genet, 2002
One of the mapped loci myotubularin related protein 4 (MTMR4) potentially extends the proximal boundary of a conserved linkage group.
FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate.
Zhao et al., Nashville, United States. In Exp Cell Res, 2001
Here, we report a novel isozyme that we designated FYVE-DSP2.
Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
Mandel et al., Illkirch-Graffenstaden, France. In Hum Mol Genet, 1998
MTMR4 belongs to the myotubularin family of phosphoinositides phosphatases
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