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Metal-regulatory transcription factor 1

MTF-1, Myt1
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Melanotransferrin, CAN, V1a, ACID, SP1
Papers on MTF-1
In Vivo toxicological assessment of biologically synthesized silver nanoparticles in adult Zebrafish (Danio rerio).
Yun et al., Chŏnju, South Korea. In J Hazard Mater, Feb 2016
Hence to confirm the oxidative stress and genotoxic effects the mRNA expression of stress related (MTF-1, HSP70) and immune response related (TLR4, NFKB, IL1B, CEBP, TRF, TLR22) genes were analyzed in liver tissues and the results clearly concluded that the plant extract mediated synthesis of AgNPs leads to oxidative stress and immunotoxicity in adult zebrafish.
Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.
Chun et al., Kwangju, South Korea. In Osteoarthritis Cartilage, Jan 2016
OBJECTIVE: Hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis in chondrocytes serve as catabolic regulators of osteoarthritic cartilage destruction by regulating the expression of catabolic factor genes.
Osteoarthritis year in review 2015: biology.
Malfait, Chicago, United States. In Osteoarthritis Cartilage, Jan 2016
Highlights include a homeostatic role for CXC chemokines in cartilage, identification of the zinc-ZIP8-MTF1 axis as an essential regulator of cartilage catabolism, and the discovery that a small aggrecan fragment can have catabolic and pro-inflammatory effects through Toll-like receptor 2. Synovitis can promote joint damage, partly through alarmins such as S100A8.
Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc.
Newcomb et al., Seattle, United States. In Toxicol Appl Pharmacol, Jan 2016
MT expression is regulated by metal-regulatory transcription factor 1 (MTF1).
CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma.
Mangues et al., Barcelona, Spain. In Head Neck, Nov 2015
The best multi-gene decision-tree model to predict local recurrence included nuclear receptor coactivator 1 (NCOA1) and serum-amyloid A2 (SAA2) expression, whereas the best model to predict disease recurrence included creatine kinase mitochondrial 1 (CKMT1) and metal-regulatory transcription factor 1 (MTF1).
Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming.
Zhang et al., Dallas, United States. In Stem Cell Reports, Nov 2015
We demonstrate that the transcription factors SOX2 and MYT1 specifically interact with this genomic element to directly regulate Tlx enhancer activity in vivo.
Emerging regulators of the inflammatory process in osteoarthritis.
Terkeltaub et al., San Diego, United States. In Nat Rev Rheumatol, 2015
Integral to this reprogramming are 'switching' pathways in transcriptional networks, other than the well-characterized effects of NFκB and mitogen-activated protein kinase signalling; HIF-2α transcriptional signalling and ZIP8-mediated Zn(2+) uptake, with downstream MTF1 transcriptional signalling, have been implicated but further validation is required.
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level.
Opoka et al., Kraków, Poland. In Acta Biochim Pol, 2014
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways.
Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.
Becker et al., Bonn, Germany. In Nat Commun, 2014
Here we provide evidence that the metal-regulatory transcription factor 1 (MTF1) mediates the increase of CaV3.2 mRNA and intrinsic excitability consequent to a rise in intracellular Zn(2+) that is associated with SE.
Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.
Forrest et al., Yokohama, Japan. In Front Genet, 2014
In the core TRN (i.e., TF-TF only), NEUROD1 directly transcriptionally activates the pancreatic TFs HSF4, INSM1, MLXIPL, MYT1, NKX6-3, ONECUT2, PAX4, PROX1, RFX6, ST18, DACH1, and SHOX2, while LMX1A directly transcriptionally activates DACH1, SHOX2, PAX6, and PDX1.
Structural metal sites in nonclassical zinc finger proteins involved in transcriptional and translational regulation.
Michel et al., Chŏnju, South Korea. In Acc Chem Res, 2014
There are three ZFs in this family: neural zinc finger factor-1 (NZF-1), myelin transcription factor-1 (MyT1), and suppressor of tumorgenicity 18 (ST18).
Zinc'ing sensibly: controlling zinc homeostasis at the transcriptional level.
Bird et al., Columbus, United States. In Metallomics, 2014
Zinc-responsive transcription factors are found in all kingdoms of life and include the transcriptional activators ZntR, SczA, Zap1, bZip19, bZip23, and MTF-1, and transcriptional repressors Zur, AdcR, Loz1, and SmtB.
Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis.
Chun et al., Kwangju, South Korea. In Cell, 2014
Furthermore, MTF1 was identified as an essential transcription factor in mediating Zn2+/ZIP8-induced catabolic factor expression, and genetic modulation of Mtf1 in mice altered OA pathogenesis.
The taste of heavy metals: gene regulation by MTF-1.
Schaffner et al., Zürich, Switzerland. In Biochim Biophys Acta, 2012
The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator involved in cellular adaptation to various stress conditions, primarily exposure to heavy metals but also to hypoxia or oxidative stress.
Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.
Wang et al., Salt Lake City, United States. In Nucleic Acids Res, 2012
nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1.
A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1).
Schaffner et al., Zürich, Switzerland. In Biochim Biophys Acta, 2012
Results identify a cysteine cluster that mediates homodimerization of human MTF-1, and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity.
Dissection of Drosophila MTF-1 reveals a domain for differential target gene activation upon copper overload vs. copper starvation.
Schaffner et al., Zürich, Switzerland. In Int J Biochem Cell Biol, 2012
Activation of this gene induced under opposite conditions of copper load and copper starvation manifested itself in a shortened lifespan, crippled wings, and female sterility.
The role of small ubiquitin-like modifier-interacting motif in the assembly and regulation of metal-responsive transcription factor 1.
Lin et al., Taiwan. In J Biol Chem, 2012
It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm
Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1).
Séguin et al., Canada. In Biochem Cell Biol, 2011
MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.
X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation.
Pieler et al., Göttingen, Germany. In Cell, 1997
X-MyT1 is a C2HC-type zinc finger protein that we find to be involved in the primary selection of neuronal precursor cells in Xenopus.
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