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Metastasis associated 1

MTA1, metastasis-associated protein 1
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, POLYMERASE, HAD, V1a, CAN
Papers using MTA1 antibodies
Reading and function of a histone code involved in targeting corepressor complexes for repression.
Xie Jingwu, In PLoS ONE, 2004
... H3R17me2a and TIF1β/KAP1 from Abcam (Cambridge, MA, USA); HA from Roche Molecular Biochemicals; nucleolin and MTA1 from eBioscience (San Diego, CA) and ...
Papers on MTA1
Neuroprotective effects of a chromatin modifier on ischemia/reperfusion neurons: implication of its regulation of BCL2 transactivation by ERα signaling.
Zhao et al., Xi'an, China. In Cell Tissue Res, Feb 2016
Here, we report the upregulated expression of metastasis-associated protein 1 (MTA1), a master chromatin modifier and transcriptional regulator, in the murine middle cerebral artery occlusion (MCAO) model.
Endocrine MPA enhances the effects of TAC chemotherapy on improvement of prognosis and increase in long-term survival rates for patients with endometrial cancer.
Zhang et al., China. In Oncol Lett, Sep 2015
Furthermore, the mean metastasis-associated 1 (MTA1) protein and RNA expression levels were significantly lower in the experimental group compared with the control group (P<0.05),
Constructing Chimeric Antigen for Precise Screening of HTLV-I Infection.
Rasaee et al., Sabzevār, Iran. In Iran J Allergy Asthma Immunol, Aug 2015
Individual preparation of two human T-cell lymphotropic virus type I (HTLV-I) diagnostic GST fused peptides (MTA-1 and GD21) is time-consuming and expensive.
Structure and function insights into the NuRD chromatin remodeling complex.
Klaholz et al., Illkirch-Graffenstaden, France. In Cell Mol Life Sci, Jul 2015
NuRD is a 1 MDa multi-subunit protein complex which comprises many different subunits, among which histone deacetylases HDAC1/2, ATP-dependent remodeling enzymes CHD3/4, histone chaperones RbAp46/48, CpG-binding proteins MBD2/3, the GATAD2a (p66α) and/or GATAD2b (p66β) and specific DNA-binding proteins MTA1/2/3.
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.
Shang et al., Beijing, China. In Cancer Cell, Jul 2015
Here, we report that GATA3 nucleates a transcription repression program composed of G9A and MTA3-, but not MTA1- or MTA2-, constituted NuRD complex.
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?
Micke et al., Uppsala, Sweden. In Expert Rev Mol Diagn, Apr 2015
Only 26 proteins first described after 2008 (ALDH1A1, ANXA1, BCAR1, CLDN1, EIF4E, EZH2, FOLR1, FOXM1, IL7R, IL12RB2, KIAA1524, CRMP1, LOX, MCM7, MTA1, MTDH, NCOA3, NDRG2, NEDD9, NES, PBK, PPM1D, SIRT1, SLC7A5, SQSTM1 and WNT1) demonstrated a consistent prognostic association in two or more independent patient cohorts, thus qualifying as promising candidates for diagnostic use.
Subcellular localization of MTA proteins in normal and cancer cells.
Qian et al., Beijing, China. In Cancer Metastasis Rev, 2014
MTA1, MTA2, and MTA3 are the main members of the MTA family.
Clinical implications of MTA proteins in human cancer.
Dutt et al., Mumbai, India. In Cancer Metastasis Rev, 2014
Metastasis-associated gene or metastasis tumor antigen 1 (MTA1) is a new member of cancer progression-related gene family.
Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer.
Kumar et al., Shanghai, China. In Adv Cancer Res, 2014
Since the initial recognition of the metastasis-associated protein 1 (MTA1) as a metastasis-relevant gene approximately 20 years ago, our appreciation for the complex role of the MTA family of coregulatory proteins in human cancer has profoundly grown.
MTA1-upregulated EpCAM is associated with metastatic behaviors and poor prognosis in lung cancer.
Qian et al., Dongguan, China. In J Exp Clin Cancer Res, 2014
BACKGROUND: Overexpression of Metastasis-associated protein 1 (MTA1) in various cancer cells promotes tumor invasion and migration and predicts cancer patients' poor prognosis.
MTA1 promotes metastasis of MPM via suppression of E-cadherin.
Shen et al., Suzhou, China. In J Exp Clin Cancer Res, 2014
BACKGROUND: Metastasis-associated gene 1(MTA1) has been identified as an oncogene in many tumors, and aberrant MTA1 expression has been linked to carcinogenesis and metastasis.
Laparoscopic surgery inhibits the proliferation and metastasis of cervical cancer cells.
Li et al., Haikou, China. In Int J Clin Exp Med, 2014
Similarly, the expression of metastasis promoting gene MTA1 in cervical cancer cells was lowered by laparoscopic surgery, but not affected by laparotomy.
Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function.
Kumar et al., Washington, D.C., United States. In J Biol Chem, 2012
Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function.
MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells.
Chen et al., Guangzhou, China. In Oncol Rep, 2012
MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression
Aberrant expression levels of MTA1 and RECK in nasopharyngeal carcinoma: association with metastasis, recurrence, and prognosis.
Yin et al., Xiamen, China. In Ann Otol Rhinol Laryngol, 2012
The conversely abnormal expression levels of MTA1 and RECK may be collectively involved in progression of malignancies and may serve as molecular predictors for metastasis, recurrence, and prognosis of nasopharyngeal carcinoma.
Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.
Sharma et al., Atlanta, United States. In J Biol Chem, 2012
Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.
Metastasis-associated protein 1 nuclear expression is closely associated with tumor progression and angiogenesis in patients with esophageal squamous cell cancer.
Hao et al., Jinan, China. In World J Surg, 2012
High expression of MTA1 protein is closely associated with esophageal tumor progression, increased tumor angiogenesis, and poor survival.
A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm.
Vadlamudi et al., Houston, United States. In Nature, 2002
naturally occurring short form that contains a previously unknown sequence of 33 amino acids with an ER-binding motif, Leu-Arg-Ile-Leu-Leu (LRILL); MTA1s localizes in the cytoplasm, sequesters ER in the cytoplasm, and enhances non-genomic responses of ER
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
Kumar et al., Houston, United States. In Nat Cell Biol, 2001
Here we report the identification of metastatic-associated protein 1 (MTA1), a component of histone deacetylase (HDAC) and nucleosome-remodelling complexes, as a gene product induced by heregulin-beta1 (HRG).
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
Reinberg et al., United States. In Cell, 1998
The complex contains the histone deacetylases HDAC1/2, histone-binding proteins, the dermatomyositis-specific autoantigen Mi2beta, a polypeptide related to the metastasis-associated protein 1, and a novel polypeptide of 32 kDa.
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