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Matrix metallopeptidase 15

MT2-MMP, Matrix Metalloproteinase 15, MMP-15
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MT1-MMP, MT1, MMP-2, MT3-MMP, MMP-9
Papers on MT2-MMP
Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity.
Ito et al., Tsu, Japan. In Int J Oncol, Feb 2016
The level of matrix metallopeptidase 15 (MMP15) mRNA expression was significantly reduced, whereas the level of laminin alpha 3 (LAMA3) and secreted phosphoprotein 1 (SPP1) mRNA expression was significantly increased in Huh7 cells following exposure to C646.
Body Water Status and Short-term Maximal Power Output during a Multistage Road Bicycle Race (Giro d'Italia 2014).
Gatterer et al., Monza, Italy. In Int J Sports Med, Jan 2016
vector-length shortened (p<0.001) and MMP15 (maximal mean power for 15 s; p=0.043) decreased in the course of the Giro d'Italia.
MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.
Croce et al., Ferrara, Italy. In Proc Natl Acad Sci U S A, Aug 2015
Enforced expression of miR-148a sensitized cells to TRAIL and reduced lung tumorigenesis in vitro and in vivo through the down-modulation of matrix metalloproteinase 15 (MMP15) and Rho-associated kinase 1 (ROCK1).
LPP inhibits collective cell migration during lung cancer dissemination.
Tanaka et al., Akita, Japan. In Oncogene, Jul 2015
Here, we showed that LPP degraded N-cadherin in lung cancer, PC14PE6 cells via regulating the expression of matrix metalloproteinase 15 (MMP-15), and loss-of-LPP increases collective cell migration (CCM) and dissemination consequently.
MiRNA expression profile and miRNA-mRNA integrated analysis (MMIA) during podocyte differentiation.
Yang et al., Tianjin, China. In Mol Genet Genomics, Jun 2015
The expressions of three remarkably changed miRNAs (miR-34c, miR-200a and miR-467e) and four mRNAs (Runx1t1, Atp2a2, Glrp1, and Mmp15), were randomly chosen for further validation by the quantitative real-time polymerase chain reaction, and their expression trends were consistent with the microarray data.
Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes.
Grüll et al., Eindhoven, Netherlands. In Molecules, 2014
This ACPP, called ACPP-B, showed high sensitivity towards MT1-MMP, soluble MMP-2, and MT2-MMP, while limited sensitivity was measured for other members of the MMP family.
Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis.
Lan et al., Suzhou, China. In Int J Clin Exp Pathol, 2014
In our research, three type tissue samples of human, pituitaries, PAs, IPAs, their mRNA expression of MMP1, MMP2, MMP9, MMP14 and MMP15 were measured using real-time PCR.
Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis.
Jiang et al., Changzhou, China. In Int J Clin Exp Pathol, 2014
In despite of many reports in other solid tumors, the role of membrane type-2 MMP (MT2-MMP) in gastric cancer (GC) remains to be elucidated.
Overexpression of membrane-type 2 matrix metalloproteinase induced by hypoxia-inducible factor-1α in pancreatic cancer: Implications for tumor progression and prognosis.
Wu et al., Chengdu, China. In Mol Clin Oncol, 2014
Membrane-type 2 matrix metalloproteinase (MT2-MMP) has been identified as a powerful modulator of the pericellular environment that promotes tumor invasion and metastasis.
Disentangling the multifactorial contributions of fibronectin, collagen and cyclic strain on MMP expression and extracellular matrix remodeling by fibroblasts.
Vogel et al., Zürich, Switzerland. In Matrix Biol, 2014
MMP-15 (RT-qPCR), and MMP-9 activity (zymography), while subsequent exposure to collagen slightly reduced MMP-15 expression and MMP-9 activity compared to Fn-exposure alone.
Dysregulated expression of matrix metalloproteinases and their inhibitors may participate in the pathogenesis of pre-eclampsia and fetal growth restriction.
Yu et al., Guangzhou, China. In Early Hum Dev, 2014
We evaluated the expressions of MMP-2, -8, -9, -11, -19, -15 (MT2-MMP), -16 (MT3-MMP), and -24 (MT5-MMP), as well as TIMP-1 and -3, by applying Western blot and immunohistochemistry methods.
MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer.
Jiang et al., Changzhou, China. In Int J Clin Exp Pathol, 2013
We previously reported that membrane type-2 MMP (MT2-MMP) is highly expressed in human esophageal cancer tissues, and its expression level is positively correlated to tumor size and intratumoral angiogenesis.
Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins.
Ogiwara et al., Sapporo, Japan. In Zoolog Sci, 2013
Follicle rupture in medaka ovulation involves the cooperation of the tissue inhibitor of metalloproteinase-2b protein with at least three matrix metalloproteinases (MMP): membrane type-1 MMP (MT1-MMP), MT2-MMP, and gelatinase A. Our studies also indicate that the serine protease, i.e., plasmin, participates in the rupture for only a few hours prior to the activation of MMP-mediated hydrolysis at ovulation.
Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages.
Roncucci et al., Reggio nell'Emilia, Italy. In Int J Oncol, 2012
MMP-15 and MMP-19 are upregulated during colorectal tumorigenesis
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development.
Lincoln et al., Miami, United States. In Dev Biol, 2011
Data indicate that Snai1 is sufficient to promote mmp15 expression, cell transformation, and mesenchymal cell migration and invasion.
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Tobin et al., Leicester, United Kingdom. In Nat Genet, 2011
We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2.
Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1α in cancer cells.
Wu et al., Wuhan, China. In Mol Carcinog, 2011
Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha under hypoxia.
Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer.
Xu et al., Suzhou, China. In Anticancer Res, 2010
The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues.
Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.
El-Merzabani et al., Cairo, Egypt. In Int J Biol Markers, 2010
MMP2 activity is associated with an increase in MT2-MMP expression and with lymph node metastasis.
Proteases in brain tumour progression.
Nutall et al., Ljubljana, Slovenia. In Acta Neurochir (wien), 2003
Membrane bound MT-MMPs, in particular MT1- and MT2-MMP, seem to play a major role in activating MMP-2.
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