Chemistry and biology of mammalian metallothioneins.
Zürich, Switzerland. In J Biol Inorg Chem, 2011
The first discovered MT-1/MT-2 are widely expressed isoforms, whose biosynthesis is inducible by a wide range of stimuli, including metals, drugs, and inflammatory mediators.
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.
Portland, United States. In Nature, 1997
Intracerebroventricular administration of the agonist, MTII, inhibited feeding in four models of hyperphagia: fasted C57BL/6J, ob/ob, and A(Y) mice, and mice injected with neuropeptide Y. Co-administration of the specific melanocortin antagonist and agouti-mimetic SHU9119 completely blocked this inhibition.