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Metallothionein 2A

MT-2, MTII, metallothionein IIA
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, CD4, V1a
Papers on MT-2
Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates-proof of concept for HIV mucosal pre-exposure prophylaxis.
Sinko et al., United States. In Drug Deliv Transl Res, Feb 2016
In MT-2 T cells, APV-PEG3.4
Barium chloride induces redox status unbalance, upregulates cytokine genes expression and confers hepatotoxicity in rats-alleviation by pomegranate peel.
Zeghal et al., Sfax, Tunisia. In Environ Sci Pollut Res Int, Feb 2016
Liver total MT levels, MT-1, and MT-2 and pro-inflammatory cytokine genes expression like TNF-α, IL-1β and IL-6 were increased.
Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT.
Blindauer et al., Coventry, United Kingdom. In Int J Mol Sci, Dec 2015
Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters.
Cloning, characterization, and expression of cadmium-induced metallothionein-2 gene from earthworm Pheretima aspergillum (E. Perrier).
Yu et al., Guangzhou, China. In Genet Mol Res, 2014
To investigate the mechanisms of enrichment of Cd in the earthworm Pheretima aspergillum, we isolated and cloned metallothionein-2 (MT-2) cDNA (538 bp) from P. aspergillum, analyzed its sequence, and examined MT-2 transcription levels by relative quantitative real-time PCR under different concentrations of Cd.
Metallothioneins in the lung cancer.
Podhorska-Okolow et al., Wrocław, Poland. In Folia Histochem Cytobiol, 2014
Four groups of MTs are distinguished: MT-1, MT-2, MT-3 and MT-4.
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.
la Fleur et al., Amsterdam, Netherlands. In Front Behav Neurosci, 2014
Melanocortin sensitivity was tested by measuring food intake following administration of the melanocortin 3/4 receptor agonist melanotan II (MTII) or vehicle in the lateral ventricle.
Biphasic effect of melanocortin agonists on metabolic rate and body temperature.
Reitman et al., Bethesda, United States. In Cell Metab, 2014
Intraperitoneal administration of the nonselective melanocortin agonist MTII causes a melanocortin-4 receptor (Mc4r)-mediated hypermetabolism/hyperthermia.
The private life of environmental bacteria: pollutant biodegradation at the single cell level.
de Lorenzo et al., Madrid, Spain. In Environ Microbiol, 2014
As a case example, we examine the stochastic and multi-stable behaviour of the TOL-encoded pathway of Pseudomonas putida mt-2 for the biodegradation of aromatic compounds.
Significance of metallothioneins in aging brain.
Ebadi et al., Netherlands. In Neurochem Int, 2014
In general, MT-1 and MT-2 induce cell growth and differentiation, whereas MT-3 is a growth inhibitory factor, which is reduced in Alzheimer's disease.
Development of a high sensitivity ELISA for the assay of metallothionein.
Nakajima et al., Maebashi, Japan. In Curr Pharm Biotechnol, 2012
We have developed a competitive ELISA using a polyclonal antibody that showed specificity to both metallothionin (MT)-1 and MT-2 isoforms in human and animal specimens.
Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients.
Elovaara et al., Tampere, Finland. In J Neuroimmunol, 2012
These data showing the association of polymorphisms in the TPH2 and MTNR1B genes with the progressive subtypes of multiple sclerosis and disability suggest dysregulation in melatonin pathway
The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors.
von Gall et al., Frankfurt am Main, Germany. In Chronobiol Int, 2012
Endogenous melatonin signal facilitates reentrainment of the circadian system to phase advances on the level of the suprachiasmatic nucleus molecular clockwork by acting upon MT2 receptors.
The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population.
Mastorakos et al., Athens, Greece. In Hormones (athens), 2012
This study confirms the association of gestational diabetes mellitus with the rs10830963 variant in a sample of the Greek population.
Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women.
Deng et al., Chengdu, China. In Plos One, 2011
The MTNR1B is likely to be involved in the regulation of glucose homeostasis during pregnancy.
Chemistry and biology of mammalian metallothioneins.
Meloni et al., Zürich, Switzerland. In J Biol Inorg Chem, 2011
The first discovered MT-1/MT-2 are widely expressed isoforms, whose biosynthesis is inducible by a wide range of stimuli, including metals, drugs, and inflammatory mediators.
Down-regulation of metallothionein 1 and 2 after exposure to electromagnetic field in mouse testis.
Roushandeh et al., Tabrīz, Iran. In Iran Biomed J, 2010
Down-regulation of MT1 and MT2 after electromagnetic fields in mouse testis might be followed by some consequences that result in infertility.
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.
Palmiter et al., Seattle, United States. In Nat Genet, 1999
We show here that Mc4r-deficient (Mc4r-/-) mice do not respond to the anorectic actions of MTII, an MSH-like agonist, suggesting that alpha-MSH inhibits feeding primarily by activating Mc4r.
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.
Cone et al., Portland, United States. In Nature, 1997
Intracerebroventricular administration of the agonist, MTII, inhibited feeding in four models of hyperphagia: fasted C57BL/6J, ob/ob, and A(Y) mice, and mice injected with neuropeptide Y. Co-administration of the specific melanocortin antagonist and agouti-mimetic SHU9119 completely blocked this inhibition.
Switch transcripts in immunoglobulin class switching.
Radbruch et al., Köln, Germany. In Science, 1995
Switch recombination can be directed to immunoglobulin G1 (IgG) by the heterologous human metallothionein IIA promoter in mutant mice.
Features of HIV-1 that could influence maternal-child transmission.
Levy et al., San Francisco, United States. In Jama, 1994
All the HIV-1 isolates were able to infect human macrophages with only low-level replication and were unable to form syncytia in the MT-2-lymphocytic cells.
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