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Y box protein 2

MSY2, Contrin, YBX2
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, ACID, MEN, HAD, POLYMERASE
Papers on MSY2
Position-dependent interactions of Y-box protein 2 (YBX2) with mRNA enable mRNA storage in round spermatids by repressing mRNA translation and blocking translation-dependent mRNA decay.
Kleene, Boston, United States. In Mol Reprod Dev, Feb 2016
Two lines of evidence implicate the highly abundant and well-known translational repressor, Y-box protein 2 (YBX2), as a critical factor: First, the protamine 1 (Prm1) and sperm-mitochondria cysteine-rich protein (Smcp) mRNAs are prematurely recruited onto polysomes in Ybx2-knockout mouse round spermatids.
Association of NR3C1/Glucocorticoid Receptor gene SNP with azoospermia in Japanese men.
Enomoto et al., Niigata, Japan. In J Obstet Gynaecol Res, Jan 2016
RESULTS: Three candidate genes (NR3C1, YBX2, and BCL2) were identified by the transcriptome network analysis, each with three SNP.
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
Eichenlaub-Ritter et al., Bielefeld, Germany. In Hum Reprod, Jan 2016
Denuded in vivo or in vitro matured MII oocytes were postovulatory aged and analyzed by semiquantitative confocal microscopy for abundance and localization of polyadenylated RNAs, proteins of maternal effect genes (transcription activator BRG1 also known as ATP-dependent helicase SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4) and NOD-like receptor family pyrin domain containing 5 (NLRP5) also known as MATER), RNA-binding proteins (MSY2 also known as germ cell-specific Y-box-binding protein, YBX2), and post-transcriptionally modified histones (trimethylated histone H3K9 and acetylated histone H4K12), as well as pericentromeric ATRX (alpha thalassemia/mental retardation syndrome X-linked, also termed ATP-dependent helicase ATRX or X-linked nuclear protein (XNP)).
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
Kato et al., Japan. In J Reprod Dev, Jan 2016
Furthermore, a synergy effect with SOX2 was observed for an additional 10 factors, FOXJ1, HES1, HEY1, HEY2, KLF6, MSX1, RUNX1, TEAD2, YBX2 and ZFP36Ll, which did not show substantial independent action.
Compound Heterozygosity for Y Box Proteins Causes Sterility Due to Loss of Translational Repression.
Braun et al., Bar Harbor, United States. In Plos Genet, Dec 2015
The Y-box proteins YBX2 and YBX3 bind RNA and DNA and are required for metazoan development and fertility.
Comparison of Protamine 1 to Protamine 2 mRNA Ratio and YBX2 gene mRNA Content in Testicular Tissue of Fertile and Azoospermic Men.
Hashjin et al., Qazvīn, Iran. In Int J Fertil Steril, Oct 2015
After RNA extraction and cDNA synthesis, real-time quantitative polymerase chain reaction (RT- QPCR) was used to analyze the PRM1, PRM2, Y box binding protein 2 (YBX2) and JmjC-containing histone demethylase 2a (JHDM2A) genes in testicular biopsies of the studied samples.
Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.
Schultz et al., Philadelphia, United States. In Biol Reprod, Aug 2015
We previously demonstrated that phosphorylation of MSY2, an RNA-binding protein, and mobilization of mRNAs encoding the DCP1A-DCP2 decapping complex contribute to maternal mRNA destruction during meiotic maturation.
Expression profiles of select genes in cumulus-oocyte complexes from young and aged mares.
Isom et al., In Reprod Fertil Dev, Jun 2015
Three genes (mitochondrial translational initiation factor 3 (IF3), heat shock transcription factor 5 (HSF5) and Y box binding protein 2 (YBX2)) were differentially expressed in oocytes, with all being more abundant in oocytes from young mares.
Mechanisms of translational repression of the Smcp mRNA in round spermatids.
Kleene et al., Boston, United States. In Reproduction, 2015
RNA affinity chromatography and mass spectrometry sequencing identified Y-box protein 2 (YBX2/MSY2) as the major protein that interacts with the 3' terminus of the Smcp 3'-UTR and a Y-box recognition sequence, GCCACCU, in the translation control element that is necessary for Prm1 mRNA repression.
Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse.
Schultz et al., Praha, Czech Republic. In Curr Top Dev Biol, 2014
Full-grown oocytes are transcriptionally quiescent and mRNAs are remarkably stable in oocytes due to the RNA-binding protein MSY2, which stabilizes mRNAs, and low activity of the 5' and 3' RNA degradation machinery.
Evaluation of mRNA Contents of YBX2 and JHDM2A Genes on Testicular Tissues of Azoospermic Men with Different Classes of Spermatogenesis.
Rashvand et al., Qazvīn, Iran. In Cell J, 2014
OBJECTIVE: Animal model studies have shown that MSY2 and JHDM2A genes have an important role in spermatogenesis process and fertility of male mice.
Mechanosensitive channels Msy1 and Msy2 are required for maintaining organelle integrity upon hypoosmotic shock in Schizosaccharomyces pombe.
Iida et al., Koganei, Japan. In Fems Yeast Res, 2014
The mechanosensitive channels, Mys1 and Msy2, in fission yeast are localized in the endoplasmic reticulum membrane and control cytoplasmic Ca(2+) levels in the hypoosmotic response.
Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome.
Schultz et al., Philadelphia, United States. In Biol Reprod, 2011
central role in regulating mRNA stability
MIWI-independent small RNAs (MSY-RNAs) bind to the RNA-binding protein, MSY2, in male germ cells.
Hecht et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2009
Results show that MSY-RNAs are in both nuclei and cytoplasm.
Sequence alterations in the YBX2 gene are associated with male factor infertility.
Carrell et al., Salt Lake City, United States. In Fertil Steril, 2009
A significant association between gene alterations in the YBX2 gene and abnormal spermatogenesis in humans, including a potential role in altering protamine expression, and implicate YBX2 gene alterations as a potential cause of male factor infertility.
The aetiology of sperm protamine abnormalities and their potential impact on the sperm epigenome.
Hammoud et al., Salt Lake City, United States. In Int J Androl, 2008
While the variants of the protamine genes themselves do not appear to be responsible for most observed defects, variants of the Contrin gene, a transcription factor and translation repressor, appear to be contributory to some cases of abnormal expression.
CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation.
Schultz et al., Philadelphia, United States. In Dev Biol, 2008
Study reports that CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers an abrupt transition in which most maternal mRNAs are significantly degraded.
MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis.
Hecht et al., Philadelphia, United States. In Int J Androl, 2008
MSY2 is a highly conserved and abundant DNA/RNA-binding protein that functions as a global stabilizer/translational suppressor of mRNAs in male germ cells.
Some single nucleotide polymorphisms of MSY2 gene might contribute to susceptibility to spermatogenic impairment in idiopathic infertile men.
Zhang et al., Chengdu, China. In Urology, 2008
some polymorphisms of the MSY2 gene might be associated with impaired spermatogenesis and that the gene could also be involved in modifying the susceptibility to idiopathic spermatogenic impairment in humans
Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
Dean et al., Bethesda, United States. In Semin Reprod Med, 2007
Mouse transgenesis has been particularly useful in defining germ-cell specific genes and their roles in folliculogenesis (e.g., DAZLA, FIGLA, NOBOX, SOHLH1, YBX2, CPEB1, GDF9), fertilization (e.g., ZP1, ZP2, ZP3), and preimplantation embryonic development (e.g., NPM2, ZAR1, NALP5, DPPA3).
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