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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Homeobox, msh-like 1

MSX1, Msx2, PFM
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PAX9, HAD, LIP, BMP4
Papers using MSX1 antibodies
Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors. Biochem Biophys Res Commun.
Bachmann Michael P., In PLoS ONE, 2008
... Expression constructs for LYL1, GATA2, GATA3, MSX2, and NKX3-1 have been cloned in vector pCMV6 and were obtained from Origene (Wiesbaden, Germany) ...
Papers on MSX1
Epigenetic regulation of the homeobox gene MSX1 associates with platinum resistant disease in high grade serous epithelial ovarian cancer.
Brown et al., London, United Kingdom. In Clin Cancer Res, Feb 2016
The role of Msh homeobox 1 (MSX1) in drug sensitivity was investigated by gene reintroduction and siRNA knockdown of ovarian cancer cell lines.
Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families.
Zhang et al., Shanghai, China. In Osteoporos Int, Feb 2016
The associations between the 51 SNPs and peak BMD and body composition [including the TLM, percentage lean mass (PLM), TFM, percentage fat mass (PFM), and the body mass index (BMI)] were analyzed through quantitative transmission disequilibrium tests (QTDTs).
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Greber et al., Münster, Germany. In Cell Stem Cell, Jan 2016
We found that WNT inhibition serves to restrict expression of anti-cardiac regulators MSX1 and CDX2/1.
Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development.
Schambony et al., Erlangen, Germany. In Bmc Dev Biol, Dec 2015
ALK3 and ALK6 are independently required for the spatially restricted activation of BMP signaling and msx2 upregulation at the neural plate border, whereas in post-gastrula development ALK6 exerts a highly specific, conserved function in neural crest development.
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia.
Lin et al., Shanghai, China. In Sci Rep, Dec 2015
We scanned another female with non-syndromic anodontia and her younger brother with the same gene mutations of the PAX9,MSX1,AXIN2 and EDA, but without developmental abnormalities in the dentition.
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population.
In Neuro Endocrinol Lett, Dec 2015
Among genes involved in tooth morphogenesis, mutations in PAX9, MSX1, AXIN2, WNT10a, and EDA genes have been associated with tooth agenesis.
Pelvic floor muscle displacement during voluntary and involuntary activation in continent and incontinent women: a systematic review.
Radlinger et al., Bern, Switzerland. In Int Urogynecol J, Nov 2015
INTRODUCTION: Investigations of the dynamic function of female pelvic floor muscles (PFM) help us to understand the pathophysiology of stress urinary incontinence (SUI).
Pelvic floor muscle activation and strength components influencing female urinary continence and stress incontinence: a systematic review.
Radlinger et al., Bern, Switzerland. In Neurourol Urodyn, Aug 2015
AIMS: A better understanding of pelvic floor muscle (PFM) activation and strength components is a prerequisite to get better insight in PFM contraction mechanisms and develop more specific PFM-training regimens for female stress urinary incontinence (SUI) patients.
Wolf-Hirschhorn syndrome (WHS) - literature review on the features of the syndrome.
Paradowska-Stolarz, Wrocław, Poland. In Adv Clin Exp Med, 2014
Multiple tooth agenesis (mainly at premolars and molars) with over-retained deciduous dentition might be associated with MSX1-gene impairment.
MSX2 in ameloblast cell fate and activity.
Berdal et al., Paris, France. In Front Physiol, 2013
Some of these factors, such as MSX2, are mainly confined to the dental epithelium.
Embryo-endometrial interactions during early development after embryonic diapause in the marsupial tammar wallaby.
Shaw et al., Melbourne, Australia. In Int J Dev Biol, 2013
Conversely, there is endometrial expression of the muscle segment homeobox gene MSX2 throughout diapause, but it is rapidly downregulated at reactivation.
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16.
Keavney et al., Newcastle upon Tyne, United Kingdom. In Nat Genet, 2013
However, a region on chromosome 4p16, adjacent to the MSX1 and STX18 genes, was associated (P = 9.5 × 10⁻⁷) with the risk of ostium secundum atrial septal defect (ASD) in the discovery cohort (N = 340 cases), and this association was replicated in a further 417 ASD cases and 2,520 controls (replication P = 5.0 × 10⁻⁵; odds ratio (OR) in replication cohort = 1.40, 95% confidence interval (CI) = 1.19-1.65;
DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.
Samant et al., Mobile, United States. In Biochem J, 2012
The negative control of beta-catenin/DKK1 feedback loop by MSX1 may potentially contribute to excessive stabilization of beta-catenin.
Novel MSX1 mutation in a family with autosomal-dominant hypodontia of second premolars and third molars.
Jagodzinski et al., Poznań, Poland. In Arch Oral Biol, 2012
The novel c.T671C mutation might be the etiological variant of the MSX1 gene responsible for the lack of permanent teeth in the tested family.
Loss of Msx2 function down-regulates the FoxE3 expression and results in anterior segment dysgenesis resembling Peters anomaly.
Liu et al., Taiwan. In Am J Pathol, 2012
These results provide the first direct genetic evidence of the involvement of MSX2 in Peters anomaly and the distinct function of MSX2 in regulating the growth and development of lens vesicles.
Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.
Dey et al., Cincinnati, United States. In Dev Cell, 2012
Msx1 and Msx2 are critical for epithelial-mesenchymal interactions during development, and also play crucial roles in embryo implantation. Loss of Msx1/Msx2 expression correlates with altered uterine luminal epithelial cell polarity.
[Changes in the expression of Dlx5, Msx2, and Dlx5/Msx2 in hPDLSCs loaded with cyclic tensile stress].
Zhao et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2011
Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression.
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.
Shi et al., Boston, United States. In Nature, 2010
Lastly, genetic and molecular evidence supports a model whereby PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways.
Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence.
Lyonnet et al., Paris, France. In Nat Genet, 2009
The mutation abrogates the in vitro enhancer function and alters binding of the transcription factor MSX1 as compared to the wild-type sequence.
MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis.
Abate-Shen et al., United States. In Science, 2004
Msx1 and histone H1b bind to a key regulatory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repressed chromatin; Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture
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