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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Lysyl-tRNA synthetase

MSK1, lysyl-tRNA synthetase, Lysine-tRNA Ligase, LysRS
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, MAPK, CAN, V1a, Histone
Papers using MSK1 antibodies
A polycomb repression signature in metastatic prostate cancer predicts cancer outcome.
Randau Lennart, In PLoS ONE, 2006
... GARS (glycyl-tRNA synthetase, rabbit polyclonal, Abcam, Cambridge, MA), WARS (tryptophanyl-tRNA synthetase, rabbit polyclonal, Abcam), KARS (lysyl-tRNA synthetase, rabbit polyclonal, Bethyl Laboratories, Montgomery, TX), β-tubulin ...
Papers on MSK1
Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent.
Vederas et al., Edmonton, Canada. In Angew Chem Int Ed Engl, Feb 2016
The antimalarial agent cladosporin is a nanomolar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against both blood- and liver-stage infection.
PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming.
Autenrieth et al., Tübingen, Germany. In J Immunol, Feb 2016
Furthermore, inhibition of p38 and downstream MSK1 prevented IL-10 production, which in turn reduced the capacity of DCs to activate regulatory T cells.
Shiga Toxins Trigger the Secretion of Lysyl-tRNA Synthetase to Enhance Proinflammatory Responses.
Kim et al., Taejŏn, South Korea. In J Microbiol Biotechnol, Jan 2016
Here, we showed that enzymatically active Stxs trigger the dissociation of lysyl-tRNA synthetase (KRS) from the multi-aminoacyl-tRNA synthetase complex in human macrophage-like differentiated THP-1 cells and its subsequent secretion.
The Proteome of Primary Prostate Cancer.
Flores-Morales et al., Copenhagen, Denmark. In Eur Urol, Jan 2016
Molecular analysis indicated that some of the proteins overexpressed in tumors, such as carnitine palmitoyltransferase 2 (CPT2, fatty acid transporter), coatomer protein complex, subunit alpha (COPA, vesicle secretion), and mitogen- and stress-activated protein kinase 1 and 2 (MSK1/2, protein kinase) regulate the proliferation of PCa cells.
Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Qadri et al., Tübingen, Germany. In Sci Rep, 2014
The mitogen- and stress-activated kinase MSK1/2 plays a decisive role in apoptosis.
Potential involvement of IL-17F in asthma.
Hizawa et al., Tsukuba, Japan. In J Immunol Res, 2013
We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway.
Making memories of stressful events: a journey along epigenetic, gene transcription, and signaling pathways.
Reul, Bristol, United Kingdom. In Front Psychiatry, 2013
We discovered a novel, rapid non-genomic mechanism in which glucocorticoids via glucocorticoid receptors facilitate signaling of the ERK-MAPK signaling pathway to the downstream nuclear kinases MSK1 and Elk-1 in dentate gyrus granule neurons.
Non-canonical roles of lysyl-tRNA synthetase in health and disease.
Razin et al., Jerusalem, Israel. In Trends Mol Med, 2013
Lysyl-tRNA synthetase (LysRS) is a highly conserved enzyme that is part of the translational machinery in all living cells.
Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease.
Brouillet et al., Fontenay-aux-Roses, France. In Front Cell Neurosci, 2013
Recent research shows that some of these striatal markers have a pro-survival/neuroprotective role in neurons (e.g., MSK1, A2A, and CB1 receptors) whereas others enhance the susceptibility of striatal neurons to mHtt (e.g., Rhes, RGS2, D2 receptors).
Structure and function of MK5/PRAK: the loner among the mitogen-activated protein kinase-activated protein kinases.
Kostenko et al., Tromsø, Norway. In Biol Chem, 2013
Eleven mammalian MAPK-activated protein kinases have been identified, and they are divided into five subgroups: the ribosomal-S6-kinases RSK1-4, the MAPK-interacting kinases MNK1 and 2, the mitogen- and stress-activated kinases MSK1 and 2, the MAPK-activated protein kinases MK2 and 3, and the MAPK-activated protein kinase MK5 (also referred to as PRAK).
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Zoghbi et al., Houston, United States. In Nature, 2013
Our approach revealed that downregulation of several components of the RAS-MAPK-MSK1 pathway decreases ATXN1 levels and suppresses neurodegeneration in Drosophila and mice.
Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling.
Racke et al., Columbus, United States. In J Biol Chem, 2012
by suppression of both NF-kappaB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation.
Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner.
Imokawa et al., Hachiōji, Japan. In Exp Dermatol, 2012
Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner
Activation of human mitochondrial lysyl-tRNA synthetase upon maturation of its premitochondrial precursor.
Mirande et al., Gif-sur-Yvette, France. In Biochemistry, 2012
Data are consistent with hypothesis that maturation of cytoplasmic KARS precursor is needed to reveal the potent tRNA binding properties of mitochondrial KARS.
Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.
Chen et al., Taipei, Taiwan. In Eur J Pharmacol, 2012
the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages
Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes.
Rahman et al., Rochester, United States. In Plos One, 2011
MSK1 is an important downstream kinase involved in CS-induced NF-kappaB activation
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling.
Arthur et al., Dundee, United Kingdom. In Nat Immunol, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases.
The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.
Razin et al., Jerusalem, Israel. In Immunity, 2004
Here, we have found that lysyl-tRNA synthetase (LysRS) is also associated with MITF and forms a multicomplex with MITF and Hint.
A euryarchaeal lysyl-tRNA synthetase: resemblance to class I synthetases.
Söll et al., New Haven, United States. In Science, 1997
The sequencing of euryarchaeal genomes has suggested that the essential protein lysyl-transfer RNA (tRNA) synthetase (LysRS) is absent from such organisms.
Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions.
Patterson et al., Denver, United States. In Nat Genet, 1997
Two proteins, lysyl-tRNA synthetase and translocon-associated protein delta, interact with mutant forms of SOD1 but not with wild-type SOD1.
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