Genetic susceptibility to lung cancer and co-morbidities.
Brisbane, Australia. In J Thorac Dis, 2013
Large scale, multi-cohort GWAS of mainly Caucasian, smoking, populations have identified strong associations for lung cancer mapped to chromosomal regions 15q [nicotinic acetylcholine receptor (nAChR) subunits: CHRNA3, CHRNA5], 5p (TERT-CLPTM1L locus) and 6p (BAT3-MSH5).
[Common variable immunodeficiency].
Tokyo, Japan. In Nihon Rinsho, 2012
Responsible genes identified so far include ICOS, TACI, CD19, CD20, CD21, CD81, BAFF-R, MSH5, PLCD2, and LRBA; and most of the CVID-causing genes are yet to be identified.
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
United Kingdom. In Nat Genet, 2008
Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).
Common variable immunodeficiency in children.
London, United Kingdom. In Curr Opin Pediatr, 2007
RECENT FINDINGS: Five genes, ICOS, CD19, TNFRSF13B, TNFRSF13C and MSH5, have been found to be mutated in patients with common variable immunodeficiency.