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Mitochondrial ribosomal protein L11

MRPL11, CGI-113
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GalR2, SAP 145, L7/L12, GalR3, Neuropeptide
Papers on MRPL11
Normalization of Reverse Phase Protein Microarray Data: Choosing the Best Normalization Analyte.
Chiechi, Indianapolis, United States. In Methods Mol Biol, Dec 2015
Using geNorm and NormFinder algorithms, we screened seven normalization analytes (ssDNA, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), α/β-tubulin, mitochondrial ribosomal protein L11 (MRPL11), ribosomal protein L13a (RPL13a), β-actin, and total protein) across different sample sets, including cell lines, blood contaminated tissues, and tissues subjected to laser capture microdissection (LCM), to identify the analyte with the lowest variability.
Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma.
Koc et al., Huntington, United States. In Mitochondrion, Sep 2015
Evidence provided in this study suggests for the first time that the mitochondrial translation defect(s) could be due to a decrease in the expression of one of the essential mitochondrial ribosomal proteins, MRPL11, in head and neck tumor biopsies.
Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli.
Koc et al., United States. In Protein Expr Purif, 2011
The homologs of these proteins, MRPL10, MRPL11, and MRPL12, are present in human mitochondrial ribosomes.
The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Hata et al., Chiba, Japan. In Genes Chromosomes Cancer, 2009
In clinical samples, six genes (GAL, GSTP1, MRPL11, MRPL21, SF3B2, and YIF1A) at 11q13.1-13.3 and one gene (GALR1) at 18q23 showed a significant difference between normal and tumor samples.
Feedback regulation of c-Myc by ribosomal protein L11.
Lu et al., Indianapolis, United States. In Cell Cycle, 2007
This review suggests that ribosomal protein L11 inhibits cell cycle progression by feedback regulation of the oncoprotein c-Myc pathway.
5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction.
Lu et al., Portland, United States. In J Biol Chem, 2007
5-FU treatment triggers a ribosomal stress response so that ribosomal proteins L5, L11, and L23 are released from ribosome to activate p53 by ablating the MDM2-p53 feedback circuit
Nuclear photosynthetic gene expression is synergistically modulated by rates of protein synthesis in chloroplasts and mitochondria.
Leister et al., Köln, Germany. In Plant Cell, 2006
The mrpl11 and prpl11 mutants are impaired in the mitochondrial and plastid ribosomal L11 proteins, respectively.
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer.
Stokke et al., Oslo, Norway. In Bmc Genomics, 2005
Expressions of eight of these genes (MRPL11, CKS2, PDK2, MRPS23, MSN, TBX3, KLF3, LSM3) correlated with progression free survival in univariate analysis and were therefore more strongly associated with metastatic phenotypes than the others.
A new epitope tag from hepatitis B virus preS1 for immunodetection, localization and affinity purification of recombinant proteins.
Hong et al., Taejŏn, South Korea. In J Immunol Methods, 2003
The mutated epitope (NANNPDWDF), designated S1 tag, was fused to the amino (N)- or carboxyl (C)-terminus of three human recombinant proteins, soluble B lymphocyte stimulator (sBLyS), the N-terminal domain of thrombopoietin (nTPO), and a mitochondrial ribosomal protein (CGI-113) for expression in mammalian cells, while it was fused to the N- or C-terminus of two proteins, a single-chain antibody fragment (ScFv) and the carboxyl-terminal domain (PAc) of the protective antigen of Bacillus anthracis for expression in Escherichia coli.
[Structural and functional analysis of the human ribosomal protein L11 gene].
Filipenko et al., Novosibirsk, Russia. In Mol Biol (mosk), 2003
The nucleotide sequence was established for the human ribosomal protein L11 gene (HRPL11)
Characterization of a wheat cDNA encoding mitochondrial ribosomal protein L11: qualitative and quantitative tissue-specific differences in its expression.
Murayama et al., Sapporo, Japan. In Mol Genet Genomics, 2001
Localized fluorescence was detectable in mitochondria, indicating that this nuclear cDNA encodes a mitochondrial ribosomal protein L11 (MRPL11).
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