Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison.
Berlin, Germany. In Clin Sci (lond), Feb 2015
Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects.
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice.
Beijing, China. In Plos One, 2014
The incidence of a foot shaking evoked by indentation of the dorsum of foot with an aversive von Frey filament (tip diameter 200 μm, bending force 20 mN) was significantly higher in the foot ipsilateral to the CCD surgery as compared to the contralateral side on post-operative days 2 to 8. Mechanically-evoked action potentials were electrophysiologically recorded from the L3 DRG, in vivo, from cell bodies visually identified as expressing a transgenically labeled fluorescent marker (neurons expressing either the receptor MrgprA3 or MrgprD).
Role of non-classical renin-angiotensin system axis in renal fibrosis.
Nanjing, China. In Front Physiol, 2014
The new members have added new dimensions to RAS, including the ACE2/Ang(1-7)/Mas receptor axis, the prorenin/(pro)renin receptor(PRR)/intracelluar pathway axis, and the Angiotensin A (Ang A), alamandine-Mas-related G protein coupled receptor D(MrgD) axis.
Alamandine: a new member of the angiotensin family.
Rio Grande, Brazil. In Curr Opin Nephrol Hypertens, 2014
PURPOSE OF REVIEW: In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed.
Mechanisms of itch evoked by β-alanine.
Baltimore, United States. In J Neurosci, 2012
Here we show that, in mice, β-alanine elicited itch-associated behavior that requires MrgprD, a G-protein-coupled receptor expressed by a subpopulation of primary sensory neurons.
Projection of non-peptidergic afferents to mouse tooth pulp.
Baltimore, United States. In J Dent Res, 2012
For clear visualization of the non-peptidergic afferents, we took advantage of a recently generated knock-in mouse model in which an axonal tracer, farnesylated green fluorescence protein (GFP), is expressed from the locus of a sensory neuron-specific gene, Mrgprd.