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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

AT rich interactive domain 5B

Mrf-2, ARID5B, modulator recognition factor-2, Desrt, Mrf2beta, Mrf2alpha
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, p16, Tec
Papers on Mrf-2
Knockdown of AT-rich interaction domain (ARID) 5B gene expression induced AMPKα2 activation in cardiac myocytes.
Itakura et al., New Hope, United States. In Biosci Trends, Dec 2015
This study demonstrated that ARID5B mRNA is present in mouse cardiomyocyte HL-1 cells, and that ARID5B siRNA constantly knocked down ARID5B gene expression to the 40% level of control.
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer.
Polenakovic et al., Скопје, Macedonia. In Prostate, Oct 2015
We evidenced for the first time the dysregulation of 9 proteins (CSNK1A1, ARID5B, LYPLA1, PSMB6, RABEP1, TALDO1, UBE2N, PPP1CB, and SERPINB1) that may have role in PCa.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Kellis et al., Macedonia. In N Engl J Med, Oct 2015
The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation.
Bricca et al., Lyon, France. In J Hypertens, Jun 2015
Ninety-one TRs had high positive (CI+) or negative (CI-) connecting index with core-VSMcontr specifically in MIT or ATH: 49 TRs with high CI+ (including NRF1, SRF and THRA) and 16 with high CI- (including HIF1A and STAT1) were MIT-specific, whereas 17 (including ERCC6, PRRX1 and ARID5B) and 9 (including RNF4 and USF1) other TRs had respectively high CI+ and high CI- and were ATH-specific.
Rs4948496 within ARID5B gene is associated with clinical features of systemic lupus erythematosus in the Chinese Han population.
Zhang et al., Hefei, China. In J Dermatol, Jun 2015
In our previous meta-analysis of genome-wide association study, we identified the single nucleotide polymorphism (SNP) rs4948496 (P = 5.1 × 10(-11) , odds ratio [OR] = 0.85) within the ARID5B gene associated with systemic lupus erythematosus (SLE) in a Chinese population.
Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.
Buffler et al., Berkeley, United States. In Cancer Causes Control, Apr 2015
BACKGROUND: Genome-wide association studies focusing on European-ancestry populations have identified ALL risk loci on IKZF1, ARID5B, and CEBPE.
Genetic susceptibility in childhood acute leukaemias: a systematic review.
Pombo-de-Oliveira et al., Rio de Janeiro, Brazil. In Ecancermedicalscience, 2014
We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B, and IKZF1.
ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study.
Clavel et al., Villejuif, France. In Plos One, 2014
Genome-wide association studies (GWAS) have identified that frequent polymorphisms in ARID5B and IKZF1, two genes involved in lymphoid differentiation, increase the risk of childhood acute lymphoblastic leukemia (ALL).
Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA.
Wiemels et al., Berkeley, United States. In Plos One, 2014
These SNPs are located at CDKN2A (rs3731217) and IKZF1 (rs4132601), genes frequently lost in ALL, and at CEBPE (rs2239633), ARID5B (rs7089424), PIP4K2A (rs10764338), and GATA3 (rs3824662), genes located on chromosomes gained in high-hyperdiploid ALL.
Differential expression of arid5b isoforms in Xenopus laevis pronephros.
Umbhauer et al., Paris, France. In Int J Dev Biol, 2013
Arid5b belongs to the ARID family of transcription factors characterised by a helix-turn-helix motif- based DNA-binding domain called ARID (A-T Rich Interaction Domain).
Integrated genomic characterization of endometrial carcinoma.
Levine et al., In Nature, 2013
Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B.
[Research advances on correlation of ARID5B gene with childhood acute lymphoblastic leukemia - review].
Shen et al., Wuxi, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2012
Recently, two independent large-scale genome-wide association studies reported that the five single nucleotide polymorphisms (rs7073837; rs10821936; rs10994982; rs7089424; rs10740055) in the gene AT rich interactive domain 5B (ARID5B) at 10q21.2, were associated with the high incidence risk of C-ALL, especially with hyperdiploid lymphoblastic leukemia.
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Yamamoto et al., Yokohama, Japan. In Nat Genet, 2012
Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.
Yang et al., Memphis, United States. In J Clin Oncol, 2012
ARID5B polymorphisms are important determinants of childhood ALL susceptibility and treatment outcome, and they contribute to racial disparities in this disease.
Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the Polish population.
Młynarski et al., Łódź, Poland. In Leuk Res, 2011
Single nucleotide polymorphism in ARID5B gene is associated with childhood acute lymphoblastic leukemia.
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.
Kato et al., Tokyo, Japan. In Nat Cell Biol, 2011
Here, we characterized a protein kinase A (PKA)-dependent histone lysine demethylase complex, PHF2-ARID5B.
Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.
Sinnett et al., Montréal, Canada. In Haematologica, 2010
confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia
ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence.
Relling et al., In Leukemia, 2010
ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence.
Modulator recognition factor-2 regulates triglyceride metabolism in adipocytes.
Itakura et al., Duarte, United States. In Biochem Biophys Res Commun, 2010
knockdown of Mrf-2 increases the rate of fatty acid recycling in 3T3-L1-derived adipocytes.
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