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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protease, serine 27

Pancreasin is a pancreatic tryptic serine peptidase that cleaves peptides after an arginine residue.[supplied by OMIM, Sep 2003] (from NCBI)
Top mentioned proteins: JAK2, CAN, HAD, BCR, MPL
Papers on MPN
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
Wagner et al., Pomona, United States. In Neuroendocrinology, Feb 2016
UNASSIGNED: Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis.
Timing of the loss of PTEN protein determines disease severity in a mouse model of myeloid malignancy.
Emanuel et al., Little Rock, United States. In Blood, Feb 2016
UNASSIGNED: Juvenile Myelomonocytic Leukemia (JMML) is an aggressive pediatric mixed myelodysplastic/myeloproliferative neoplasm (MDS/MPN).
Thrombocytosis and STAT5 activation in chronic myelogenous leukaemia are not associated with JAK2 V617F or calreticulin mutations.
Theil et al., Cleveland, United States. In J Clin Pathol, Feb 2016
We investigated the JAK2 V617F, CALR and STAT5 activation status in patients with CML and thrombocytosis (CML-T) that mimicked ET, trying to identify a common mechanism for thrombocytosis in MPN.
Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
Ravid et al., Boston, United States. In Blood, Feb 2016
UNASSIGNED: Lysyl oxidase (LOX) is overexpressed in various pathologies associated with thrombosis, such as arterial stenosis and myeloproliferative neoplasms (MPN).
Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.
Mesa et al., Scottsdale, United States. In J Clin Oncol, Feb 2016
PURPOSE: Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with disabling symptoms and a heightened risk of life-threatening complications.
IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms.
Traina et al., Campinas, Brazil. In Oncotarget, Feb 2016
UNASSIGNED: The recurrent V617F mutation in JAK2 (JAK2V617F) has emerged as the primary contributor to the pathogenesis of myeloproliferative neoplasms (MPN).
The evolution and clinical relevance of prognostic classification systems in myelofibrosis.
Verstovsek et al., Houston, United States. In Cancer, Jan 2016
Risk factors for thrombosis and conversion to MPN blast phase also are discussed.
Management of symptoms in polycythemia vera and essential thrombocythemia patients.
Geyer et al., London, United Kingdom. In Hematology Am Soc Hematol Educ Program, Jan 2016
We will review the advances in the field of MPN symptom assessment and symptom burden experienced by ET and PV patients.
Acquired uniparental disomy of chromosome 9p in hematological malignancies.
Prchal et al., Houston, United States. In Exp Hematol, Dec 2015
Since then, systematic application of genome-wide single nucleotide polymorphism arrays has demonstrated that 9p aUPD is the most common chromosomal aberration in myeloproliferative neoplasms (MPN) contributing to discovery of PV-defining mutation JAK2(V617F).
The genomic landscape of juvenile myelomonocytic leukemia.
Loh et al., San Francisco, United States. In Nat Genet, Nov 2015
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis.
Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
Plo et al., Villejuif, France. In Nat Genet, Oct 2015
No major predisposition gene for familial myeloproliferative neoplasms (MPN) has been identified.
Structure of mammalian eIF3 in the context of the 43S preinitiation complex.
Hashem et al., New York City, United States. In Nature, Oct 2015
Eight subunits having PCI (proteasome, COP9 signalosome, eIF3) or MPN (Mpr1, Pad1, amino-terminal) domains constitute the structural core of eIF3, to which five peripheral subunits are flexibly linked.
CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
Levine et al., New York City, United States. In Cancer Cell, Aug 2015
Although clinically tested JAK inhibitors reduce splenomegaly and systemic symptoms, molecular responses are not observed in most myeloproliferative neoplasm (MPN) patients.
The Hematopoietic Niche in Myeloproliferative Neoplasms.
Zeiser et al., Freiburg, Germany. In Mediators Inflamm, 2014
A structural and functional remodeling of the niche may contribute to the development of myeloproliferative neoplasms (MPN).
MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives.
Bjørn et al., Roskilde, Denmark. In Mediators Inflamm, 2014
The MPN population has a substantial inflammation-mediated comorbidity burden.
The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds.
Kirchhofer et al., San Francisco, United States. In J Biol Chem, 2009
Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
Caughey et al., San Francisco, United States. In J Biol Chem, 2003
structure and activity of the human enzyme, a serine peptidase found in the pancreas
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