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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Prostaglandin E synthase

mPGES-1, prostaglandin E synthase, PGES, mPGES, microsomal prostaglandin E synthase-1
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cyclooxygenase, Cyclooxygenase 2, ACID, V1a, CAN
Papers using mPGES-1 antibodies
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression
Descalzi Cancedda Fiorella et al., In Arthritis Research & Therapy, 2008
... ), anti-COX-2 polyclonal antiserum and anti-mPGES-1 antibodies were from Cayman Chemical (Ann Arbor, MI, ...
Therapeutic options for 5-lipoxygenase inhibitors
Werz Oliver et al., In Frontiers in Pharmacology, 2005
... The antibody against human mPGES-1 was from Cayman Chemical (Ann Arbor, MI, ...
Papers on mPGES-1
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
Haeggström et al., Stockholm, Sweden. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Microsomal prostaglandin E2 synthase type 1 (mPGES-1) is responsible for the formation of the potent lipid mediator prostaglandin E2 under proinflammatory conditions, and this enzyme has received considerable attention as a drug target.
mPGES-1-derived PGE2 Contributes to Adriamycin-induced Podocyte Injury.
Zhang et al., Nanjing, China. In Am J Physiol Renal Physiol, Feb 2016
The present study was undertaken to investigate the role of microsomal prostaglandin E synthase-1 (mPGES-1) in adriamycin (ADR)-induced podocyte injury, as well as the underlying mechanism.
Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.
Fisher et al., In J Pharmacol Exp Ther, Feb 2016
Microsomal prostaglandin E2 synthase (mPGES-1) is a membrane bound terminal enzyme in the prostanoid pathway, which acts downstream of cyclooxygenase 2 and is responsible for PGE2 production.
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors.
Bifulco et al., Salerno, Italy. In Bioorg Med Chem, Feb 2016
Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.
Filosa et al., Napoli, Italy. In Eur J Med Chem, Jan 2016
Moreover we have identified 6f and 6l as dual 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors and compound 6l significantly reduces inflammatory reactions in the carrageenan-induced mouse paw oedema.
Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.
Fiebich et al., Belo Horizonte, Brazil. In J Neuroinflammation, Dec 2015
METHODS: In the present study, we evaluated the effect of poly(I:C) on the production of prostaglandin E2 (PGE2) and the inducible enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) in primary rat microglia.
Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.
Werz et al., Jena, Germany. In Biochem Pharmacol, Dec 2015
However, 15 years after intensive research on the biology and pharmacology of mPGES-1, the therapeutic value of mPGES-1 as drug target is still vague and mPGES-1 inhibitors did not enter the market so far.
Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation.
Ishii, Tsukuba, Japan. In Free Radic Biol Med, Nov 2015
Prx1 secreted from cells under mild oxidative stress binds Toll-like receptor 4 and induces NF-κB activation, important for the expression of cyclooxygenase-2 and microsomal PGE synthase-1 (mPGES-1) expression.
Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
Hara et al., Tokyo, Japan. In Prostaglandins Other Lipid Mediat, Sep 2015
Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) and mPGES-1-derived PGE2 have gained attention recently as alternative targets to COX-2 for colorectal cancer chemoprevention and chemotherapy.
Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment.
Jakobsson et al., Stockholm, Sweden. In Prostaglandins Other Lipid Mediat, Jul 2015
Genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), the enzyme responsible for the second step of the PGE2 biosynthesis, has resulted in reduced tumor progression in mouse models of colon cancer.
Potential role of aspirin in the prevention of aneurysmal subarachnoid hemorrhage.
Hasan et al., Charlottesville, United States. In Cerebrovasc Dis, 2014
Walls of ruptured human intracranial aneurysms have higher levels of COX-2 and microsomal prostaglandin E2 synthase 1 (mPGES-1), both of which are known to be inhibited by aspirin.
Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
Divangahi et al., Montréal, Canada. In Immunity, 2014
Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype.
Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35.
Hara et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These results indicated that mPGES-1 is induced during Abeta-mediated neuronal cell death and is involved in Abeta-induced neurotoxicity associated with Alzheimer's disease pathology.
Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
Heistad et al., Iowa City, United States. In Stroke, 2012
Cyclooxygenase-2/mPGES-1 are expressed in the wall of human cerebral aneurysms and more abundantly so in ruptured aneurysms than in nonruptured.
Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.
Rubin et al., Toronto, Canada. In Circulation, 2012
Lack of mPGES-1 in bone marrow-derived leukocytes negatively regulates COX-1 expression, PGE2 biosynthesis, and inflammation in myocrdial infarct and leads to impaired left ventricle function, adverse LV remodeling, and decreased survival.
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Ogawa et al., Tokyo, Japan. In Toxicol Sci, 2012
Suggest that COX-2 and PGES, and in turn PGE(2), might play important roles in follicular cell proliferation but do not affect tumor induction in N-bis(2-hydroxypropyl)nitrosamine-induced thyroid carcinogenesis model.
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Tohyama et al., Tokyo, Japan. In Toxicol Sci, 2012
mPGES-1 upregulation upon lactational TCDD exposure is a causal factor for TCDD-induced hydronephrosis in mouse neonates.
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Jakobsson et al., Stockholm, Sweden. In Pharmacol Rev, 2007
cytosolic PGE synthase (cPGES) and two membrane-bound PGE synthases, mPGES-1 and mPGES-2.
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.
Miyano et al., Japan. In Nature, 2007
10), is an 18-kDa integral nuclear membrane protein that belongs to a superfamily of membrane-associated proteins in eicosanoid and glutathione metabolism that includes 5-lipoxygenase-activating protein, microsomal glutathione S-transferases (MGSTs), and microsomal prostaglandin E synthase 1 (ref.
Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction.
Mitsudomi et al., Nagoya, Japan. In J Clin Oncol, 2004
Next, we tried to identify a smaller number of genes of particular predictive value, and eight genes (PTK7, CIT, SCNN1A, PGES, ERO1L, ZWINT, and two ESTs) were selected.
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