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WD repeat domain 83

Morg1, MAPK organizer 1, mitogen-activated protein kinase organizer 1
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: MAPK, CAN, ERK, V1a, erythropoietin
Papers on Morg1
Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury.
Wolf et al., Jena, Germany. In Am J Physiol Renal Physiol, Apr 2015
Due to oxygen deficiency, mammalian cells activate the transcriptional factor hypoxia-inducible factor (HIF); its degradation is regulated by prolyl hydroxylase 3 (PHD3) in interaction with the scaffold protein MAPK organizer 1 (Morg1).
The role of hypoxia and Morg1 in renal injury.
Wolf et al., Jena, Germany. In Eur J Clin Invest, Mar 2015
RESULTS: The MAPK organizer 1 (Morg1) has been identified to act as a scaffold protein of PHD3 and suppression of Morg1 leads to the stabilization of HIF-α, which forms in the absence of oxygen a heterodimer with HIF-β, translocates to the nucleus and promotes the transcription of HIF target genes.
Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold.
Petersen et al., Ames, United States. In Microbes Infect, 2014
Studies using growth factors and cell lines have shown that targeted, robust, intracellular phosphorylation of ERK1/2 from phagolysosomes required recruitment and association with scaffolding proteins, including p14/MP1 and MORG1, on the surface of late endosomes.
Advanced glycated end-products affect HIF-transcriptional activity in renal cells.
Wolf et al., Jena, Germany. In Mol Endocrinol, 2013
MAPK organizer 1 (Morg1) via its binding partner prolyl-hydroxylase domain (PHD)-3 presumably plays a role in the regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α transcriptional activation.
The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.
Sumimoto et al., Fukuoka, Japan. In J Cell Biol, 2013
Here, we show that the WD40 protein Morg1 (mitogen-activated protein kinase organizer 1) directly binds to Par6 and thus facilitates apical targeting of Par6-aPKC in Madin-Darby canine kidney epithelial cells.
Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.
Tikkanen et al., Gießen, Germany. In Int J Mol Sci, 2012
We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer 1.
Morg1(+/-) heterozygous mice are protected from experimentally induced focal cerebral ischemia.
Wolf et al., Jena, Germany. In Brain Res, 2012
We recently identified a new WD-repeat protein designated Morg1 (MAPK organizer 1) that interacts with prolyl hydroxylase 3 (PHD3), an important enzyme involved in the regulation of HIF-1α and HIF-2α expression.
Angiotensin II differentially regulates Morg1 expression in kidney cells.
Wolf et al., Jena, Germany. In Am J Nephrol, 2011
BACKGROUND: The mitogen-activated protein kinase organizer 1 (Morg1) belongs to the WD-40 repeat protein family and is a scaffold molecule for the extracellular regulated kinase signaling pathway.
Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury.
Wolf et al., Jena, Germany. In Am J Physiol Renal Physiol, 2009
Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion
Reduced Morg1 expression in ischemic human brain.
Wolf et al., Jena, Germany. In Neurosci Lett, 2009
Morg1 expression is reduced in human brain tissue with ischemic damage. Reactive astrocytes in the surrounding brain tissue showed strong Morg1 expression.
Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein.
Chen et al., Shanghai, China. In Chin J Physiol, 2006
As a result, we identified 14 unique proteins deregulated in AML1-ETO-carrying leukemic cells, including 3 up-regulated such as hairy and enhancer of split 5 (HES5) and 11 down-regulated such as MAT1 (menage a trois-1) and mitogen-activated protein kinase organizer 1 (MORG1).
The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3).
Wolf et al., Hamburg, Germany. In J Biol Chem, 2006
Functional characterization of the homologous rat gene.
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.
Weber et al., Charlottesville, United States. In Proc Natl Acad Sci U S A, 2004
Component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
Moore et al., Waltham, United States. In Rna, 2002
Includes the identification of this protein in C complex spliceosomes.
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