The role of hypoxia and Morg1 in renal injury.
Jena, Germany. In Eur J Clin Invest, Mar 2015
RESULTS: The MAPK organizer 1 (Morg1) has been identified to act as a scaffold protein of PHD3 and suppression of Morg1 leads to the stabilization of HIF-α, which forms in the absence of oxygen a heterodimer with HIF-β, translocates to the nucleus and promotes the transcription of HIF target genes.
Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.
Gießen, Germany. In Int J Mol Sci, 2012
We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer 1.