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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

MORC family CW-type zinc finger 2

Top mentioned proteins: MORC, Histone, p21, OUT, PAK1
Papers on MORC2
Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.
Espinós et al., Valencia, Spain. In Brain, Jan 2016
Here we present a new axonal Charcot-Marie-Tooth disease form, associated with the gene microrchidia family CW-type zinc finger 2 (MORC2).
MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs.
Nicholson et al., Australia. In Ann Neurol, Jan 2016
Whole exome sequencing identified a novel mutation (p.R252W) in the Microrchidia CW-type zinc finger 2 (MORC2) gene mapping within the linkage region.
Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells.
Li et al., Shenyang, China. In Biochem Biophys Res Commun, Dec 2015
Then, we cloned and identified ArgBP2 promoter and verified that MORC2 bound to the promoter.
By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
Wang et al., Shenyang, China. In Oncotarget, Jul 2015
Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis.
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis.
Li et al., Shenyang, China. In Oncotarget, May 2015
To date, microrchidia (MORC) family CW-type zinc-finger 2 (MORC2), has been found to be involved in p21-activated kinase1 (PAK1) pathway to maintain genomic integrity.
Identification of 33 candidate oncogenes by screening for base-specific mutations.
Aaltonen et al., Helsinki, Finland. In Br J Cancer, 2014
Fourteen genes displayed mutations in the validation set of 254 MSI CRCs: ANTXR1, MORC2, CEP135, CRYBB1, GALNT9, KRT82, PI15, SLC36A1, CNTF, GLDC, MBTPS1, OR9Q2, R3HDM1 and TTPAL.
The compromised recognition of turnip crinkle virus1 subfamily of microrchidia ATPases regulates disease resistance in barley to biotrophic and necrotrophic pathogens.
Kogel et al., Gießen, Germany. In Plant Physiol, 2014
MORC1 and MORC2, two of the seven members of the Arabidopsis (Arabidopsis thaliana) Compromised Recognition of Turnip Crinkle Virus1 subfamily of microrchidia Gyrase, Heat Shock Protein90, Histidine Kinase, MutL (GHKL) ATPases, were previously shown to be required in multiple layers of plant immunity.
Cytosolic functions of MORC2 in lipogenesis and adipogenesis.
Kumar et al., Washington, D.C., United States. In Biochim Biophys Acta, 2014
Microrchidia (MORC) family CW-type zinc finger 2 (MORC2) has been shown to be involved in several nuclear processes, including transcription modulation and DNA damage repair.
MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response.
Kumar et al., Washington, D.C., United States. In Cell Rep, 2013
Here, we report that microrchidia CW-type zinc finger 2 (MORC2), an uncharacterized protein with a derived PHD finger domain and a conserved GHKL-type ATPase module, is a physiological substrate of p21-activated kinase 1 (PAK1), an important integrator of extracellular signals and nuclear processes.
Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.
Chang et al., Taipei, Taiwan. In Plos One, 2010
After using stepwise model selection from the combination of the initial filtered genes, we developed a prediction model based on the genes SLC22A23, PRKAG3, DPEP3, MORC2, GRB7, and FAM43A.
Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells.
Li et al., Shenyang, China. In Anat Rec (hoboken), 2010
Analysis of MORC2 functional domains, subcellular localization and mRNA and protein expression demonstrates its role of nuclear localization in association with a proline-rich domain regulating gene transcriptional repression in cancer cells.
Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX.
Li et al., Shenyang, China. In Nucleic Acids Res, 2010
MORC2 is a member of the MORC protein family.
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