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MORC family CW-type zinc finger 1

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: ATPase, Histone, SET, MUC1, MORC2
Papers on MORC
The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.
Ortín et al., Madrid, Spain. In J Virol, Oct 2015
NXP2/MORC3 is a member of the Microrchidia (MORC) family that is associated with the nuclear matrix and has RNA-binding activity.
The GHKL ATPase MORC1 Modulates Species-Specific Plant Immunity in Solanaceae.
Klessig et al., Ithaca, United States. In Mol Plant Microbe Interact, Aug 2015
The microrchidia (MORC) proteins, a subset of the GHKL ATPase superfamily, were recently described as components involved in transcriptional gene silencing and plant immunity in Arabidopsis.
By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
Wang et al., Shenyang, China. In Oncotarget, Jul 2015
Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis.
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis.
Li et al., Shenyang, China. In Oncotarget, May 2015
To date, microrchidia (MORC) family CW-type zinc-finger 2 (MORC2), has been found to be involved in p21-activated kinase1 (PAK1) pathway to maintain genomic integrity.
Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers.
Jacobsen et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2014
More recently, two Arabidopsis homologues of mouse microrchidia (MORC) genes have also been implicated in gene silencing and heterochromatin condensation without altering genome-wide DNA methylation patterns.
Cytosolic functions of MORC2 in lipogenesis and adipogenesis.
Kumar et al., Washington, D.C., United States. In Biochim Biophys Acta, 2014
Microrchidia (MORC) family CW-type zinc finger 2 (MORC2) has been shown to be involved in several nuclear processes, including transcription modulation and DNA damage repair.
The compromised recognition of turnip crinkle virus1 subfamily of microrchidia ATPases regulates disease resistance in barley to biotrophic and necrotrophic pathogens.
Kogel et al., Gießen, Germany. In Plant Physiol, 2014
MORC1 and MORC2, two of the seven members of the Arabidopsis (Arabidopsis thaliana) Compromised Recognition of Turnip Crinkle Virus1 subfamily of microrchidia Gyrase, Heat Shock Protein90, Histidine Kinase, MutL (GHKL) ATPases, were previously shown to be required in multiple layers of plant immunity.
The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci.
He et al., Beijing, China. In Plos Genet, 2014
Our results indicated that SUVH2 and/or SUVH9 not only interact with the chromatin-remodeling complex termed DDR (DMS3, DRD1, and RDM1) but also with the newly characterized complex composed of two conserved Microrchidia (MORC) family proteins, MORC1 and MORC6.
MORC1 represses transposable elements in the mouse male germline.
Jacobsen et al., Los Angeles, United States. In Nat Commun, 2013
The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function.
MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD.
Szyf et al., Mannheim, Germany. In Transl Psychiatry, 2013
Several regions in MORC1 (MORC family CW-type zinc finger 1; previously known as: microrchidia (mouse) homolog) were differentially methylated in response to ELS in CD34+ cells and CD3+ T cells derived from the blood of human and monkey neonates, as well as in CD3+ T cells derived from the blood of adolescent monkeys and in the prefrontal cortex of adult rats.
[Detecting testis- and epididymis-specific methylated promoters in human cell-free seminal DNA by MeDIP-qPCR].
Xiong et al., Wuhan, China. In Zhonghua Nan Ke Xue, 2013
RESULTS: The methylation levels of the promoters PRAME, PEG10, MORC1, GML, HOXA5, DNMT3L, SNURF, MSH4, DAZ1 and CLPB were 14.93, 2.64, 0.69, 2.66, 17.50, 21.10, 5.98, 2.28, 13.50 and 3.86%, respectively, in the NZ group, obviously lower than 121.25, 73.62, 16.25, 42.90, 76.74, 112.40, 59.79, 25.85, 91.90 and 64.53% in the PV group.
The MORC family: new epigenetic regulators of transcription and DNA damage response.
Kumar et al., Washington, D.C., United States. In Epigenetics, 2013
Microrchidia (MORC) is a highly conserved nuclear protein superfamily with widespread domain architectures that intimately link MORCs with signaling-dependent chromatin remodeling and epigenetic regulation.
MORC family ATPases required for heterochromatin condensation and gene silencing.
Jacobsen et al., Los Angeles, United States. In Science, 2012
AtMORC1 and AtMORC6 are members of the conserved Microrchidia (MORC) adenosine triphosphatase (ATPase) family, which are predicted to catalyze alterations in chromosome superstructure.
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Aparicio et al., Vancouver, Canada. In Nature, 2009
Five of the 32 mutations (in ABCB11, HAUS3, SLC24A4, SNX4 and PALB2) were prevalent in the DNA of the primary tumour removed at diagnosis 9 years earlier, six (in KIF1C, USP28, MYH8, MORC1, KIAA1468 and RNASEH2A) were present at lower frequencies (1-13%), 19 were not detected in the primary tumour, and two were undetermined.
The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.
Zhao et al., Cambridge, United States. In Trends Biochem Sci, 2003
Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized.
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