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Olfactory receptor 16

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: M71, AGE, CAN, OUT, OMP
Papers on MOR23
Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography.
Mombaerts et al., Frankfurt am Main, Germany. In Proc Natl Acad Sci U S A, Nov 2015
By repeated crossing, we generated two strains of mice with gene-targeted mutations at four or five OR loci for a total of six ORs: MOR23 (Olfr16), mOR37A (Olfr155), M72 (Olfr160), P2 (Olfr17), MOR256-17 (Olfr15), and MOR28 (Olfr1507).
Postnatal odorant exposure induces peripheral olfactory plasticity at the cellular level.
Grosmaitre et al., Gif-sur-Yvette, France. In J Neurosci, 2014
Here we exposed MOR23-green fluorescent protein (GFP) and M71-GFP mice to lyral or acetophenone, ligands for MOR23 or M71, respectively.
Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23.
Mombaerts et al., Frankfurt am Main, Germany. In Eur J Neurosci, 2013
Here we have performed patch-clamp recordings from mouse OSNs that express the OR gene S1 or MOR23, using the odorous ligands 2-phenylethyl alcohol or lyral, respectively.
Olfactory receptors in non-chemosensory tissues.
Koo et al., Taegu, South Korea. In Bmb Rep, 2012
The ectopic expressions of ORs and their physiological functions have attracted more attention recently since MOR23 and testicular hOR17-4 have been found to be involved in skeletal muscle development, regeneration, and human sperm chemotaxis, respectively.
Postnatal experience modulates functional properties of mouse olfactory sensory neurons.
Ma et al., Philadelphia, United States. In Eur J Neurosci, 2012
Using a patch-clamp technique on genetically tagged OSNs with defined odorant receptors (ORs), we found that sensory deprivation increased the sensitivity of MOR23 neurons in the closed side, whereas overexposure caused the opposite effect in the open side.
Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference.
Ma et al., Philadelphia, United States. In J Neurosci, 2011
OSNs expressing mouse odorant receptor 23 (MOR23) are relatively broadly tuned in neonates and become selective detectors for the cognate odorant within 2 weeks.
Homeodomain binding motifs modulate the probability of odorant receptor gene choice in transgenic mice.
Mombaerts et al., New York City, United States. In Mol Cell Neurosci, 2011
For four mouse OR genes (M71, M72, MOR23, and P3) and one human OR gene (hM72), a mosaic, OSN-specific pattern of reporter expression can be obtained in transgenic mice with contiguous DNA segments of only ~300 bp that are centered around the transcription start site (TSS).
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb.
Vassar et al., Chicago, United States. In Mol Neurodegener, 2010
RESULTS: We bred BACE1-/- mice with gene-targeted mice in which GFP is expressed from the loci of two odorant-receptors (ORs), MOR23 and M72, and olfactory marker protein (OMP) to produce offspring that were heterozygous for MOR23-GFP, M72-GFP, or OMP-GFP and were either BACE1+/+ or BACE1-/-.
A new function for odorant receptors: MOR23 is necessary for normal tissue repair in skeletal muscle.
Pavlath, Atlanta, United States. In Cell Adh Migr, 2010
Recent work analyzing the role of mouse odorant receptor 23 (MOR23) in muscle regeneration revealed that MOR23 is necessary for proper skeletal muscle regeneration in mice as loss of MOR23 leads to increased myofiber branching.
MOR23 promotes muscle regeneration and regulates cell adhesion and migration.
Pavlath et al., Atlanta, United States. In Dev Cell, 2009
Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro.
Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice.
Ma et al., Philadelphia, United States. In Chem Senses, 2009
Using patch clamp recordings, we then examined the odorant responses of individual OSNs coexpressing a defined OR (MOR23) and green fluorescent protein.
Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids.
Luetje et al., Miami, United States. In J Neurochem, 2009
The receptive range of MOR23-1 is unique to its odorant space region.
The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.
Yagi et al., Suita, Japan. In Mol Cell Neurosci, 2008
There are multiple, small, extraneous glomeruli for the odorant receptors M71 and MOR23.
Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice.
Ma et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2006
Patch clamp recording from olfactory sensory neurons that express a defined odorant receptor provides a powerful approach to investigate the sensory inputs to individual glomeruli
Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility.
Touhara et al., Chiba, Japan. In J Cell Sci, 2004
MOR23 (a mouse OR expressed in the olfactory epithelium and testis) functions as a chemosensing receptor in mouse germ cells
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