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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Myelin oligodendrocyte glycoprotein

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, CAN, MBP, CD4, HAD
Papers using MOG antibodies
Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis
Feng Yue, In PLoS ONE, 2011
... Female C57BL/6 mice (N = 43, 8 weeks old) were immunized subcutaneously with 200 µg of MOG35–55 peptide (Invitrogen, Carlsbad, CA) emulsified in complete Freund adjuvant (CFA, Sigma Aldrich, Saint Louris, MO) on ...
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
Chi Hongbo et al., In Nature Immunology, 2010
... Kuchroo for the 2D2 MOG TCR-transgenic mice, S ...
DCs metabolize sunlight-induced vitamin D3 to ‘program’ T cell attraction to the epidermal chemokine CCL27.
Unutmaz Derya, In PLoS ONE, 2006
... DO11.10 mice (BALB/c background), MOG-TCR (2D2) transgenic mice (B6 background), IL-10 ...
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
Martino Gianvito et al., In Brain, 2005
... For targeted EAE, MOG 35-55-immunized mice [20 days post immunization (dpi)] and healthy controls (HC) were stereotaxically injected in the brain with 230 ng TNF-α and 250 ng IFN-γ (BD Biosciences, Franklin Lakes, NJ, USA) ...
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
Weber Martin Sebastian, In PLoS ONE, 1994
... MOG p35–55–specific TCR transgenic 2D2 mice were provided ...
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Papers on MOG
Orthographic processing deficits in developmental dyslexia: Beyond the ventral visual stream.
Ziegler et al., Kraków, Poland. In Neuroimage, Feb 2016
We found that in addition to significant group differences in the VWFA, dyslexic children showed a significant underactivation of the middle occipital gyrus (MOG) relative to the control group.
Salvianolic acid B ameliorates CNS autoimmunity by suppressing Th1 responses.
Yao et al., Changchun, China. In Neurosci Lett, Feb 2016
Here we show that the intraperitoneal administration of 30mg/kg Sal B daily for 14 days after the onset of MOG-induced EAE in mice effectively reduced its severity.
Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis.
Sytwu et al., Taipei, Taiwan. In Int Immunopharmacol, Jan 2016
We demonstrated that melatonin exhibits a therapeutic role by ameliorating the clinical severity and restricting the infiltration of inflammatory Th17 cells into the CNS of mice with myelin oligodendrocyte glycoprotein (MOG)-induced EAE.
The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research.
Wekerle et al., München, Germany. In Lancet Neurol, Jan 2016
Myelin oligodendrocyte glycoprotein (MOG) has received renewed attention as an antibody target in childhood multiple sclerosis and in a small subgroup of adult patients with multiple sclerosis.
Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.
Brilot et al., Sydney, Australia. In Autoimmun Rev, Jan 2016
UNASSIGNED: Myelin oligodendrocyte glycoprotein (MOG) is a protein exclusively expressed on the surface of oligodendrocytes and myelin in the central nervous system.
Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis.
Mazzon et al., Chieti, Italy. In Stem Cell Res Ther, Dec 2015
METHODS: EAE was induced by immunization with myelin oligodendroglial glycoprotein peptide (MOG)35-55 in C57BL/6 mice.
Purified Cannabidiol, the main non-psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis.
Mazzon et al., Messina, Italy. In Eur Rev Med Pharmacol Sci, Dec 2015
MATERIALS AND METHODS: Experimental Autoimmune Encephalomyelitis (EAE) was induced by immunization with myelin oligodendroglial glycoprotein (MOG)35-55 peptide in mice.
Glycans of myelin proteins.
Grandis et al., Stockholm, Sweden. In J Neurosci Res, 2015
Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan.
The influence of glutamatergic receptor antagonists on biochemical and ultrastructural changes in myelin membranes of rats subjected to experimental autoimmune encephalomyelitis.
Sulkowski et al., Warsaw, Poland. In Folia Neuropathol, 2014
The aim of the study was to test the effects of the glutamatergic receptor antagonists amantadine and memantine (antagonists of NMDA receptors), LY 367384 (an antagonist of mGluR1), and MPEP (an mGluR5 antagonist) on the development of neurological symptoms in immunized animals, morphological changes in cerebral myelin, and expression of mRNA of the principal myelin proteins PLP, MBP, MOG, MAG, and CNPase.
From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.
Wekerle et al., Israel. In J Autoimmun, 2014
The advances in technologies of genetic ablation and transgenesis in mice of C57BL/6J background and the development of myelin-oligodendrocyte glycoprotein (MOG)-induced EAE in C57BL/6J mice yielded several spontaneous and humanized EAE models, and resulted in a plethora of EAE models in which the role of specific genes or cell populations could be precisely interrogated, towards modeling specific pathways of MS pathogenesis/regulation in MS.
Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.
Meuth et al., Münster, Germany. In Nat Med, 2013
Following the induction of experimental autoimmune encephalomyelitis (EAE) by immunization with a myelin oligodendrocyte protein (MOG)35-55 peptide, Kcnk2(-/-) mice showed higher EAE severity scores that were accompanied by increased cellular infiltrates in the central nervous system (CNS).
Using EAE to better understand principles of immune function and autoimmune pathology.
Kuchroo et al., Québec, Canada. In J Autoimmun, 2013
EAE is classically induced by the immunization of mice with encephalitogenic antigens derived from CNS proteins such as proteolipid protein (PLP), myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG).
Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system.
Dalton et al., Edinburgh, United Kingdom. In J Immunol, 2012
MOG-specific CD4-positive T cells accumulate within the chemokine-expressing draining lymph nodes, rather than within the brain or spinal cord during induction of autoimmune encephalomyelitis.
Antibody response in MOG(35-55) induced EAE.
Santiago-Raber et al., Genève, Switzerland. In J Neuroimmunol, 2012
Mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein MOG(35-55) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression.
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
Krishnamoorthy et al., Martinsried, Germany. In Nature, 2011
We show further that recruitment and activation of autoantibody-producing B cells from the endogenous immune repertoire depends on availability of the target autoantigen, myelin oligodendrocyte glycoprotein (MOG), and commensal microbiota.
A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy.
Peraita-Adrados et al., Lausanne, Switzerland. In Am J Hum Genet, 2011
A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy.
RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis.
Yamashita et al., Ōsaka, Japan. In Nat Med, 2011
Neutralizing antibodies to RGMa attenuated clinical symptoms of mouse myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) and reduced invasion of inflammatory cells into the CNS.
Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis.
Genain et al., San Francisco, United States. In J Neuroinflammation, 2010
This study provides valuable information about requirements of anti-myelin oligodendrocyte glycoprotein reactivity for being regarded as a prognostic biomarker in a subtype of MS.
Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders.
Reindl et al., Innsbruck, Austria. In J Neuroinflammation, 2010
We could show for the first time that a subset of aquaporin 4-IgG seronegative patients with neuromyelitis optica exhibit a MOG-IgG mediated immune response
In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Zipp et al., Mainz, Germany. In Immunity, 2010
Direct interaction of myelin oligodendrocyte glycoprotein (MOG)-specific Th17 and neuronal cells in demyelinating lesions was associated with extensive axonal damage.
More papers using MOG antibodies
T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination.
Anderton Stephen M. et al., In Frontiers in Immunology, 1984
... Peptides corresponding to 37–46, 41–50, and 42–50 of MOG were synthesized by GL Biochem (Shanghai, China) ...
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