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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Adaptor-related protein complex 3, delta 1 subunit

Mocha, delta-adaptin, Ap3d1, Ap3d, delta-adaptin, a, Apl5, mBLVR1, adaptor-related protein complex 3 delta-1 subunit
The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: HAD, AP-1, p15, CAN, Pallid
Papers on Mocha
Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome.
Ehl et al., Freiburg, Germany. In Blood, Feb 2016
A previously described hypopigmented mouse mutant with an Ap3d1 null mutation (mocha strain) shares the neurological phenotype with our patient and shows a platelet storage pool deficiency characteristic of HPS that was not studied in our patient due to lack of bleeding.
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
Kubo et al., Yokohama, Japan. In Eur J Hum Genet, Mar 2015
(rs4618210:A>G, P = 2.60 × 10(-9), odds ratio (OR) = 0.91) and AP3D1-DOT1L-SF3A2 on chromosome 19p13.3
[Nutritional diagnosis of school children on an island of the VIII region].
Navarro R et al., In Rev Chil Pediatr, 2014
UNLABELLED: Mocha Island is part of the commune of Lebu, VIII region.
Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis.
Wells et al., London, United Kingdom. In Plos Curr, 2013
We measured expression of 11 candidate normalization genes (Cdc40, Htatsf1, Ap3d1, Csnk2a2, Fbxw2, Fbxo38, Pak1ip1, Zfp91, GAPDH, ActB, 18S) in three cell culture models of myogenesis (C2C12 , H2K2B4, and the dystrophic line H2KSF1).
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex.
Owen et al., Cambridge, United Kingdom. In Dev Cell, 2012
The linker of the delta-adaptin subunit of AP3 binds the VAMP7 longin domain and determines the structure of their complex.
Research of the Holiday kind: Tabulating Ingestion of Mocha Solution (TIMS): a longitudinal prospective cohort study.
Elkader et al., Toronto, Canada. In Cmaj, 2012
The annual "Roll Up the Rim to Win" contest at Tim Hortons restaurants provides customers the opportunity to win prizes.
Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering.
Ungermann et al., Osnabrück, Germany. In J Cell Biol, 2010
At endosomes, this motif is inserted into the lipid bilayer and masks the binding motif for the δ subunit of the AP-3 complex, Apl5, without affecting the Vps41 function in endosome-vacuole fusion.
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
Faundez et al., Atlanta, United States. In J Neurosci, 2010
This study demonstrated that distinct brain regions differentially regulate AP-3-dependent synaptic vesicle biogenesis.
Altered retinal cell differentiation in the AP-3 delta mutant (Mocha) mouse.
Kablar et al., Halifax, Canada. In Int J Dev Neurosci, 2009
Data suggest that adaptor-related protein complex 3 delta could be involved in the regulation of progenitor cell competence and the eventual ratio of resulting differentiated cells.
HOPS interacts with Apl5 at the vacuole membrane and is required for consumption of AP-3 transport vesicles.
Merz et al., Seattle, United States. In Mol Biol Cell, 2009
Data show that although the AP-3 delta subunit, Apl5, binds Vps41 directly, this interaction occurs preferentially within the context of the HOPS docking complex.
Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.
Hamilton et al., San Diego, United States. In Plos Genet, 2009
Here we show that Nxf1(CAST) suppresses a specific and frequent class of intracisternal A particle (IAP)-induced mutations, including Ap3d1(mh2J), a model for Hermansky-Pudlak syndrome, and Atcay(hes), an orthologous gene model for Cayman ataxia, among others.
HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3.
Piguet et al., Genève, Switzerland. In Traffic, 2008
The studies demonstrate a role for AP-3 in HIV replication in a tetraspanin-rich compartment in dendritic cells (DC) and contribute to the elucidation of the trafficking pathways required for DC-T cell transfer of HIV-1 infection.
Mapping of the spontaneous deletion in the Ap3d1 gene of mocha mice: fast and reliable genotyping.
Jensen et al., Århus, Denmark. In Bmc Res Notes, 2007
BACKGROUND: The mocha mouse carries a spontaneous deletion in the Ap3d1 gene, encoding the delta 1 subunit of the adaptor related protein complex 3, (Ap3d1), and subsequently lack the expression of functional AP-3.
EpsinR2 interacts with clathrin, adaptor protein-3, AtVTI12, and phosphatidylinositol-3-phosphate. Implications for EpsinR2 function in protein trafficking in plant cells.
Hwang et al., South Korea. In Plant Physiol, 2007
Protein-binding experiments showed that EpsinR2 interacts with clathrin, AtVTI12, and the Arabidopsis homologs of adaptor protein-3 delta-adaptin and adaptor protein-2 alpha-adaptin.
Screening of BRD7 interacting proteins by yeast two-hybrid system.
Li et al., Changsha, China. In Sci China C Life Sci, 2002
By sequencing directly, 6 interacting proteins of BRD7 coding protein were isolated (Bromodomain-containing 3 protein (BRD3), Bromodomain-containing 2 protein (BRD2), I kappaB kinase-beta, KIAA1375 protein, interleukin 7 and adaptor-related protein complex 3 delta-1 subunit).
Formation of AP-3 transport intermediates requires Vps41 function.
Emr et al., San Diego, United States. In Nat Cell Biol, 1999
Vps41 binds to the AP-3 delta-adaptin subunit, suggesting that they function together in the formation of ALP pathway transport intermediates at the late Golgi.
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