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Sphingomyelin synthase 1

MOB, sphingomyelin synthase, SORI, SMS1
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, fibrillin-1, V1a, HAD
Papers on MOB
Structures and unimolecular chemistry of M(Pro2-H)(+) (M = Mg, Ca, Sr, Ba, Mn, Fe, Co, Ni, Cu, Zn) by IRMPD spectroscopy, SORI-CID, and theoretical studies.
Fridgen et al., St. John's, Canada. In Phys Chem Chem Phys, Feb 2016
M(Pro2-H)(+) complexes were electrosprayed and isolated in an FTICR cell where their unimolecular chemistries and structures were explored using SORI-CID and IRMPD spectroscopy.
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
Suzuki et al., Fukuoka, Japan. In Proc Natl Acad Sci U S A, Feb 2016
Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases.
Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression.
Han et al., Jinan, China. In Febs Lett, Jan 2016
We reveal that MOB-derived exosomes significantly influence miRNA profiles in recipient ST2 cells, and these changes tend to activate the Wnt signaling pathway by inhibiting Axin1 expression and increasing β-catenin expression.
Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts.
Struhl et al., New York City, United States. In Dev Cell, Jan 2016
Specifically, we show that activity of the Drosophila NDR kinase Warts in the developing wing depends on its transition from an inactive, "closed" conformation to a potentially active, "open" conformation mediated by Mats, a conserved Mps1-binder (Mob) protein.
Warts Opens Up for Activation.
Harvey et al., Melbourne, Australia. In Dev Cell, Jan 2016
In this issue of Developmental Cell, by assessing Warts conformation in vivo, Vrabioiu and Struhl (2015) report that the Mob family protein Mats regulates Warts activity allosterically, independent of phosphorylation by Hippo.
Prenatal alcohol exposure inducing the apoptosis of mossy cells in hippocampus of SMS2-/- mice.
Deng et al., Kaifeng, China. In Environ Toxicol Pharmacol, Nov 2015
In order to understand the mechanisms of alcohol-induced neuroapoptosis through the ceramide pathway, sphingomyelin synthase 2 knockout (SMS2-/-) mice were used to make the prenatal alcohol exposure model, and the role of ceramide regulation on alcohol-induced neuroapoptosis was studied in the offspring.
Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway.
Jiang et al., Wuhan, China. In Oncotarget, Nov 2015
Physiologically, the Hippo core kinase cassette that consists of mamma-lian STE20-like protein kinase 1/2 (MST1/2), and large tumour suppressor 1/2 (LATS1/2), together with the adaptor proteins Salvador homologue 1 (SAV1) and MOB kinase activator 1 (MOB1), tightly restricts the activities of homologous oncoproteins Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) to low levels.
Isolation of methanotrophic bacteria from termite gut.
König et al., Mainz, Germany. In Microbiol Res, Oct 2015
The guts of termites feature suitable conditions for methane oxidizing bacteria (MOB) with their permanent production of CH4 and constant supply of O2 via tracheae.
The regulation and function of YAP transcription co-activator.
Zhao et al., Hangzhou, China. In Acta Biochim Biophys Sin (shanghai), 2015
Interaction with an adaptor protein MOB is also important for LATS1/2 activation.
Diverse electron sources support denitrification under hypoxia in the obligate methanotroph Methylomicrobium album strain BG8.
Stein et al., Edmonton, Canada. In Front Microbiol, 2014
Aerobic methane-oxidizing bacteria (MOB) are a diverse group of microorganisms that are ubiquitous in natural environments.
Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine.
Smith et al., Nottingham, United Kingdom. In Neuropharmacology, 2014
The proposed mechanism of cocaine is, therefore, different from other small molecule negative allostereric modulators of the monoamine reuptake transporters, eg SoRI-6238, which merely reduce the rate of inward transport.
Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma.
Busquets et al., Palma, Spain. In Biochim Biophys Acta, 2014
NaCHOleate, activates sphingomyelin synthase (SGMS) increasing the levels of cell membrane sphingomyelin (SM) and diacylglycerol (DAG) together with reductions of phosphatidylethanolamine (PE) and phosphatidylcholine (PC).
Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice.
Jiang et al., New York City, United States. In Arterioscler Thromb Vasc Biol, 2012
Sms1 deficiency decreases sphingomyelin, but dramatically increases the levels of glycosphingolipids. Atherosclerosis in Sms1(-/-)-->Ldlr(-/-) mice is significantly decreased.
CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice.
Umehara et al., Kanazawa, Japan. In Int Immunol, 2012
The deficiency of membrane sphingomyelin caused the CD4 T-cell dysfunction through impaired lipid raft function contributing to protection of ConA-induced liver injury, and suggesting that the membrane sphingomyelin is critical for full T-cell activation.
Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation.
Hattori et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2012
SMS1 and SMS2 play distinct roles in regulating local sphingomyelin clustering.
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.
Escribá et al., Palma, Spain. In Proc Natl Acad Sci U S A, 2012
Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 and SMS2.
Sphingomyelin synthases regulate protein trafficking and secretion.
Luberto et al., Charleston, United States. In Plos One, 2010
SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion
Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.
Li et al., United States. In Cell, 2005
Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in Drosophila.
Vomeronasal Receptors and Signal Transduction in the Vomeronasal Organ of Mammals
Tirindelli et al., Boca Raton, United States. In Unknown Journal, 0001
Primary sensory VNO neurons (VSNs) send axons to mitral cells in the glomerular region of the accessory olfactory bulb (AOB), whereas olfactory neurons (OSNs) to the mitral cells of the main olfactory bulb (MOB) (Baum & Kelliher 2009; Clapham & Neer 1997) (Figure 10.1).
Molecular and Neural Mechanisms of Pheromone Reception in the Rat Vomeronasal System and Changes in the Pheromonal Reception by the Maturation and Sexual Experiences
Kashiwayanagi, Boca Raton, United States. In Unknown Journal, 0001
The VSNs project information to the mitral cells (MTCs) in the AOB located on the dorsocaudal surface of the main olfactory bulb (MOB) (Rajendren et al. 1990).
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