gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Matrix metallopeptidase 21

MMP-21, matrix metalloproteinase-21, XMMP
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-28, MMP-26, MMP-7, MMP-9, ACID
Papers on MMP-21
A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Katsanis et al., Jerusalem, Israel. In J Med Genet, Dec 2015
RESULTS: We identified a homozygous 2 bp deletion in MMP21, encoding matrix metalloproteinase-21, as the sole coding mutation that segregated with the phenotype.
Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and prognosis.
Li et al., Xi'an, China. In Med Oncol, 2014
In this retrospective study of banked pathology material, we investigated the protein expression of MMP-21 in ESCC and its association with clinical significance.
High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis.
Guo et al., Beijing, China. In Oncol Rep, 2014
MMP-21 was screened based on the LNM animal model of OSCC.
Inflammation-related factors predicting prognosis of gastric cancer.
Cao et al., Shanghai, China. In World J Gastroenterol, 2014
Increased serum levels of matrix metalloproteinases (MMP)-3, MMP-7, and MMP-11 and increased levels of MMP-9, MMP-12, and MMP-21 in tumors are consistently associated with poor survival of GC.
Increased MMP-21 expression is associated with poor overall survival of patients with gastric cancer.
Du et al., Xi'an, China. In Med Oncol, 2013
Matrix metalloproteinase-21 (MMP-21) has been shown to enhance tumor invasion and metastasis ability in some solid tumors.
Regeneration of functional pronephric proximal tubules after partial nephrectomy in Xenopus laevis.
Mclaughlin et al., Medford, United States. In Dev Dyn, 2013
Importantly, this tubule restoration occurs by means of a process involving an early apoptotic event and the biphasic expression of the matrix metalloproteinase, Xmmp-9.
Identification of high-risk stage II and stage III colorectal cancer by analysis of MMP-21 expression.
Du et al., Xi'an, China. In J Surg Oncol, 2011
MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer.
Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta.
Berkowitz et al., Szeged, Hungary. In Gynecol Oncol, 2011
METHODS: Paraffin sections of 10 normal first-trimester placentas (NP), 10 partial moles (PM), 10 complete moles (CM), 5 choriocarcinomas (CCA) and 5 placental site trophoblastic tumors (PSTT) were studied immunohistochemically for expression of MMP-7, MMP-14, MMP-21, MMP-28, TIMP-3, TIMP-4 and CD147.
Overexpression of matrix metalloproteinase-21 is associated with poor overall survival of patients with colorectal cancer.
Li et al., Xi'an, China. In J Gastrointest Surg, 2011
INTRODUCTION: Matrix metalloproteinase-21 (MMP-21) is a member of the MMP family, which is overexpressed in some solid tumors and is thought to enhance the tumor invasion and metastasis ability.
Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.
Saarialho-Kere et al., Helsinki, Finland. In Virchows Arch, 2009
MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes
Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures.
Vince et al., Würzburg, Germany. In Bmc Res Notes, 2009
FINDINGS: We analysed MMP-1, -8, -9, -10, -11, -13, -17, -19, -20, -21, -23, -24, -26, -27, and MMP-28 expression in seven GBM cell-lines (SNB-19, GaMG, U251, U87, U373, U343, U138) and in four primary cell cultures by semiquantitative RT-PCR, followed changes in the MMP expression pattern with increasing passages of cell culture and examined the influence of TNF-α and TGF-β1 stimulation on the expression of selected MMPs in U251 and U373 cells.MMP-13, -17, -19 and -24 were expressed by all analyzed cell-lines, whereas MMP-20 and MMP-21 were not expressed by any of them.
MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.
Saarialho-Kere et al., Helsinki, Finland. In Exp Dermatol, 2009
MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation.
Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.
Saarialho-Kere et al., Stockholm, Sweden. In J Invest Dermatol, 2009
MMP-21 may be an important protease in the terminal differentiation of keratinocytes
Epilysin (MMP-28)--structure, expression and potential functions.
Keski-Oja et al., Helsinki, Finland. In Exp Dermatol, 2008
The epilysin homologue in Xenopus laevis (XMMP-28) is expressed in neural tissues, where it cleaves the neural cell adhesion molecule.
No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population.
He et al., Beijing, China. In Cancer Epidemiol Biomarkers Prev, 2008
A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population.
share on facebooktweetadd +1mail to friends