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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Matrix metallopeptidase 2

MMP-2, Matrix Metalloproteinase 2, gelatinase A
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-9, V1a, CAN, HAD, Akt
Papers using MMP-2 antibodies
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis
Storz Peter et al., In Breast Cancer Research : BCR, 2007
... Anti-MMP-9 was from BD Biosciences (San Jose, CA, USA) and anti-MMP-2 from Epitomics (Burlingame, CA, USA) ...
Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage
Gahmberg Carl G. et al., In The Journal of Cell Biology, 2003
... The pAbs against MMP-2 and -9 were obtained from Santa Cruz Biotechnology, Inc., and Chemicon, respectively ...
An imageable highly metastatic orthotopic red fluorescent protein model of pancreatic cancer
Han Xiao et al., In International Journal of Biological Sciences, 2003
... MMP-2 fluorimetric drug discovery kit was purchased from Biomol, USA ...
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
Koch Alisa E et al., In Arthritis Research & Therapy, 2000
... Mouse antihuman MMP-2 was purchased from R&D Systems, rabbit antimouse MMP-2 was obtained from Novus Biologicals (Littleton, CO, USA) ...
Papers on MMP-2
Associations of Promoter Methylations and mRNA Expressions of MMP-2, MMP-7 and MMP-9 with Primary Fallopian Tube Carcinoma.
Zhang et al., Huzhou, China. In Gynecol Obstet Invest, Feb 2016
OBJECTIVE: To explore the associations of matrix metalloprotease-2 (MMP-2), MMP-7 and MMP-9 methylations and messenger ribonucleic acid (mRNA) expressions with primary fallopian tube carcinoma (PFTC) development and prognosis.
Matrix Metalloproteinase 2 as a Potential Mediator of Vascular Smooth Muscle Cell Migration and Chronic Vascular Remodeling in Hypertension.
Castro et al., Ribeirão Preto, Brazil. In J Vasc Res, Feb 2016
Bioactive peptides, hemodynamic forces and reactive oxygen-nitrogen species regulate MMP-2 expression and activity.
Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology.
Swiss Neuropediatric Stroke Registry Study Group et al., Canada. In Eur J Paediatr Neurol, Jan 2016
Median levels of MMP-1, MMP-2, TIMP-1, TIMP-2, sE-selectin, sICAM-1, sVCAM-1, IL-8, IL-10, TNF-alpha, VEGF, Fetuin A were found to be higher in the neonatal group when compared with older children.
Halofuginone Treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Keshavjee et al., Toronto, Canada. In J Heart Lung Transplant, Jan 2016
Halofuginone treatment also decreased IL-17A and IL-22 transcripts at Day 14, transforming growth factor-β1 and matrix metalloproteinase-2 transcripts at Days 14 and 28.
Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse.
Gardner et al., San Francisco, United States. In J Steroid Biochem Mol Biol, Oct 2015
This was accompanied by a dramatic increase in interstitial fibrosis and increased expression of collagen 1a1 and collagen 3a1, as well as the osteopontin and matrix metalloproteinase 2, genes.
Drug Design targeting the CXCR4/CXCR7/CXCL12 pathway.
Zhong et al., Omaha, United States. In Curr Top Med Chem, Oct 2015
However, the crosstalk between CXCL12/CXCR7/CXCR4 and other signaling pathways (such as the p38 MAPK pathway, the PI3K/mTOR pathway, the STAT3 signaling, and metalloproteinases MMP-9 and MMP-2) is more complicated.
Role of interleukin 33/ST2 axis in the immune-mediated pathogenesis of age-related macular degeneration.
Dick et al., Bristol, United Kingdom. In Lancet, Mar 2015
Interleukin-33 treatment impaired fibroblast migration and gel contraction alongside suppression of MMP-2 and MMP-9 expression.
Expression characteristics of MMP-2 and MMP-9 in guinea pig ovaries during the estrous cycle.
Shen et al., Jinhua, China. In Genet Mol Res, 2014
The expression characteristics of steroidogenic acute regulatory protein (StAR), MMP-2, and MMP-9 were investigated by hematoxylin and eosin staining and immunohistochemical staining.
[Endothelial microparticles (EMP) in physiology and pathology].
Wojtukiewicz et al., In Postepy Hig Med Dosw (online), 2014
Apart from their procoagulant properties, it was demonstrated that EMP may express adhesive molecules and metalloproteinases (MMP-2, MMP-9) at their surface and release growth factors, which may contribute to angiogenesis.
Meta-analysis of association of the matrix metalloproteinase 2 (-735 C/T) polymorphism with cancer risk.
Park et al., Seoul, South Korea. In Int J Clin Exp Med, 2014
The association between matrix metalloproteinase 2 (MMP2) gene polymorphisms and cancer risk has been investigated in many published studies; however, the currently available results are inconclusive.
Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells.
Shi et al., Changsha, China. In Genet Mol Res, 2014
Transfected HKCs were co-incubated with 100 μM MMP-2 and MMP-9 inhibitor III for 24 h to affect enzyme inhibition.
Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.
Hu et al., T'ai-chung-shih, Taiwan. In Mol Nutr Food Res, 2012
Data suggest that lycopene, a dietary component, inhibits angiogenesis; lycopene appears to down-regulate signal transduction by inhibition of MMP-2 and urokinase-type plasminogen activator via vascular endothelial growth factor receptor 2 signaling.
Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes.
Klein et al., Madison, United States. In Immunity, 2012
Mucosal vaccination subverted lung T cell priming by inducing matrix metalloproteinase 2 (MMP2), which impaired the action of the chemokine CCL7 on egress of CCR2(+) Ly6C(hi) inflammatory monocytes from the bone marrow and their recruitment to the lung.
BMP2 induces PANC-1 cell invasion by MMP-2 overexpression through ROS and ERK.
Yuan et al., Shanghai, China. In Front Biosci, 2011
hypothesized that BMP2 promotes cancer metastasis by modulating MMP-2 secretion and activity through intracellular ROS regulation and ERK activation in pancreatic cancer
Determinants of circulating matrix metalloproteinase-2 and pregnancy-associated plasma protein-A in patients with chronic kidney disease.
Tesar et al., Praha, Czech Republic. In Clin Lab, 2011
Serum MMP-2 and PAPP-A were independent correlates of proteinuria, albumin, and other examined parameters in patients with chronic kidney disease.
A report of three patients with MMP2 associated hereditary osteolysis.
Zankl et al., Cairo, Egypt. In Genet Couns, 2011
MMP2 mutations can result in osteolytic disorders.
Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway.
Bhardwaj et al., New York City, United States. In Cancer Cell, 2011
Data show that MMP-2-conditioned dendritic cells primed naive CD4(+) T cells to differentiate into an inflammatory T(H)2 phenotype through OX40L expression and inhibition of IL-12p70 production.
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.
Grutzendler et al., Chicago, United States. In Nature, 2010
The rate of embolus extravasation was significantly decreased by pharmacological inhibition of matrix metalloproteinase 2/9 activity.
Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.
Berk et al., Rochester, United States. In Nat Med, 2009
Mechanistic studies showed that VSMC-derived intracellular and extracellular CypA are required for ROS generation and matrix metalloproteinase-2 activation.
Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2*-) in plasma membrane of bovine pulmonary vascular smooth muscle.
Chakraborti et al., Kalyani, India. In Indian J Biochem Biophys, 2002
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase activity, but the pretreatment with TIMP-2 inhibits the increase in the enzyme activity
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