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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Mitogen-activated protein kinase kinase kinase 9

Top mentioned proteins: MuSK, AP-1, JNK, MAPK, MLK3
Papers on MLK1
MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9.
Chen et al., Chongqing, China. In Mol Med Report, Jan 2016
Subsequently, a luciferase reporter assay verified that miR148b directly targeted mitogen‑activated protein kinase (MAPK) kinase kinase 9 (MAP3K9), an upstream activator of MAPK kinase/c‑Jun N‑terminal kinase (JNK) signaling, suppressing the protein but not the mRNA levels.
Role of miR-148a in cutaneous squamous cell carcinoma by repression of MAPK pathway.
Zhang et al., Guangzhou, China. In Arch Biochem Biophys, Nov 2015
MAP3K2, MAP3K4 and MAP3K9 were predicted as the target genes of miR-148a and the latter two genes were verified as the target genes of miR-148a in CSCC cells.
Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway.
Grill et al., Jupiter, United States. In Genetics, 2015
We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function.
Identification of B cells participated in the mechanism of postmenopausal women osteoporosis using microarray analysis.
Zhang et al., Jinan, China. In Int J Clin Exp Med, 2014
Functional enrichment analysis indicated that the genes (ITPA, ATIC, UMPS, HPRT1, COX10 and COX15) might participate in metabolic pathways, MAP3K10 and MAP3K9 might participate in the activation of JNKK activity, COX10 and COX15 might involve in mitochondrial electron transport, and ATIC, UMPS and HPRT1 might involve in transferase activity.
MiRNA profile of osteosarcoma with CD117 and stro-1 expression: miR-1247 functions as an onco-miRNA by targeting MAP3K9.
Chen et al., Bengbu, China. In Int J Clin Exp Pathol, 2014
The significant down-regulated miR-1247 was confirmed that was a potential tumor suppressor by targeting MAP3K9.
Evolution of the EKA family of powdery mildew avirulence-effector genes from the ORF 1 of a LINE retrotransposon.
Sacristán et al., Versailles, France. In Bmc Genomics, 2014
In resistant barley, MLK1 and MLA10 resistance proteins recognize the presence of AVRK1 and AVRA10, eliciting the hypersensitive response typical of gene for gene interactions.
Volumetric mammographic density: heritability and association with breast cancer susceptibility loci.
Czene et al., Stockholm, Sweden. In J Natl Cancer Inst, 2014
We also observed associations of rs9383938 (ESR1) and rs2046210 (ESR1) with the absolute dense volume (P = 2.6 × 10(-4) and 4.6 × 10(-4), respectively), and rs6001930 (MLK1) and rs17356907 (NTN4) with the absolute nondense volume (P = 6.7 × 10(-6) and 8.4 × 10(-5), respectively).
MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the Breast Cancer Health Disparities Study.
Wolff et al., Salt Lake City, United States. In Nutr Cancer, 2014
MAP3K9 was associated with breast cancer overall (P(ARTP) = 0.02) with strongest association among women with the highest IA ancestry (P(ARTP) = 0.04).
Genome-wide association discoveries of alcohol dependence.
Luo et al., New Haven, United States. In Am J Addict, 2014
The associations with the variants within NRD1, GPD1L-CMTM8 or MAP3K9-PCNX were suggestive (5 × 10(-8)  < p < 10(-5) ) in some samples, and nominally replicable in other samples.
Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.
John et al., Salt Lake City, United States. In Cancer Causes Control, 2014
However, MAP2K1 and MAP3K9 were associated with both breast cancer-specific and all-cause mortality.
Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.
Brognard et al., Los Angeles, United States. In Nat Commun, 2013
Here we demonstrate that the mixed lineage kinases (MLK1-4) are MEK kinases that reactivate the MEK/ERK pathway in the presence of RAF inhibitors.
AMD-associated genes encoding stress-activated MAPK pathway constituents are identified by interval-based enrichment analysis.
Lee et al., Bethesda, United States. In Plos One, 2012
These included sequence variants in: 1) three MAP kinase kinase kinases (MAP3K4, MAP3K5, MAP3K9) that phosphorylate and activate the MAP kinase kinases MAP2K4 and MAP2K7 (molecules that phosphorylate threonine and tyrosine residues within the activation loop of JNK); 2) a target of MAP2K7 (JNK3A1) that activates complexes involved in transcriptional regulation of stress related genes influencing cell proliferation, apoptosis, motility, metabolism and DNA repair; and 3) NR2C2, a transcription factor activated by JNK1A1 (a drugable molecule influencing retinal cell viability in model systems).
Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer.
Wolff et al., Salt Lake City, United States. In Nutr Cancer, 2012
Within the JNK MAPK-signaling pathway, interactions between MAP3K7 and protein, vitamin C, iron, folic acid, carbohydrates, and cruciferous vegetables; MAP3K10 and folic acid; MAP3K9 and lutein/zeaxanthin; MAPK8 and calcium; MAP3K3 and calcium and lutein; MAP3K1 and cruciferous vegetables.
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
Hayward et al., Brisbane, Australia. In Nat Genet, 2012
It was found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 or MAP3K9.
Cloning and Initial Functional Characterization of Mlk4α and Mlk4β.
Zabarovsky et al., Stockholm, Sweden. In Genomics Insights, 2010
MLK4 shows high amino acid homology to the kinase catalytic domain of MLK3 (72%), MLK1 (71%) and MLK2 (69%).
Repression of the estrogen receptor-alpha transcriptional activity by the Rho/megakaryoblastic leukemia 1 signaling pathway.
Flouriot et al., Rennes, France. In J Biol Chem, 2010
estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
Moss et al., Québec, Canada. In Cell Cycle, 2008
There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
Modulation of SRF-dependent gene expression by association of SPT16 with MKL1.
Murata et al., Tokyo, Japan. In Exp Cell Res, 2008
These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
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