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Myosin, light chain 12B, regulatory

The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: 20-kDa, Rhodopsin, myosin light chain kinase, V1a, RhoA
Papers on MLC20
Autoregulatory Control of Smooth Muscle Myosin Light Chain Kinase Promoter by Notch Signaling.
Proweller et al., United States. In J Biol Chem, Jan 2016
UNASSIGNED: Smooth muscle myosin light chain kinase (SM-MLCK) is the key enzyme responsible for phosphorylation of regulatory myosin light chain (MLC20), resulting in actin-myosin cross-bridging and force generation in vascular smooth muscle required for physiological vasoreactivity and blood pressure control.
High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation.
Zhou et al., Birmingham, United States. In Invest Ophthalmol Vis Sci, Jan 2016
Myofibroblast contractility was measured by fibroblast-populated three-dimensional collagen gel contraction assay and phosphorylation of myosin light chain (MLC20).
Role of connexin 43 in vascular hyperpermeability and relationship to Rock1-MLC20 pathway in septic rats.
Liu et al., Chongqing, China. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
Overexpressed Cx43 increased the phosphorylation of 20-kDa myosin light chain (MLC20) and the expression of Rock1 and increased the vascular permeability and decreased the transendothelial electrical resistance of pulmonary vein VECs.
Implications of αvβ3 Integrin Signaling in the Regulation of Ca2+ Waves and Myogenic Tone in Cerebral Arteries.
Welsh et al., Calgary, Canada. In Arterioscler Thromb Vasc Biol, Dec 2015
The RGD peptide was subsequently shown to impair Ca(2+) wave generation and myosin light chain 20 (MLC20) phosphorylation, the latter of which was attributed to the modulation of MLC kinase and MLC phosphatase via MYPT1-T855 phosphorylation.
Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.
Wilson et al., Adelaide, Australia. In Intensive Care Med Exp, Dec 2015
Platelets contract when Ca(2+)-dependent myosin light chain kinase (MLCK) phosphorylates Ser19 of myosin light chain (MLC20), promoting actin-myosin cross-bridge cycling.
Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle.
Knock et al., London, United Kingdom. In Br J Pharmacol, Nov 2015
Phosphorylation of SrcFK, FAK, myosin light-chain-20 (MLC20 ) and myosin phosphatase targeting subunit-1 (MYPT-1) was evaluated in cultured human ASM cells (hASMC).
Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion.
Luo et al., Changsha, China. In Naunyn Schmiedebergs Arch Pharmacol, Sep 2015
At the end of experiments, neurological function, infarct volume, cellular apoptosis, activities of MLCK and NOX, messenger RNA (mRNA) and protein expression of NOX (NOX1-NOX4), phosphorylation level of myosin regulatory light chain (MLC20) and hydrogen peroxide (H2O2) level were determined.
The Signaling Mechanism of Contraction Induced by ATP and UTP in Feline Esophageal Smooth Muscle Cells.
Sohn et al., Seoul, South Korea. In Mol Cells, Jul 2015
Phosphorylation of MLC20 was determined by western blot analysis.
The Effects of Lactobacillus acidophilus on the Intestinal Smooth Muscle Contraction through PKC/MLCK/MLC Signaling Pathway in TBI Mouse Model.
Zhu et al., Chongqing, China. In Plos One, 2014
Mechanistically, the decreased concentration of MLCK, phospho-MLC20 and phospho-MYPT1 and increased concentration of MLCP and PKC were observed after TBI, and these events mediated by TBI were efficiently prevented by Lactobacillus acidophilus application.
Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Grider et al., In J Smooth Muscle Res, 2013
Phosphorylation of myosin light chain (MLC20) by MLC kinase (MLCK) is a prerequisite for contraction in both circular and longitudinal muscle cells.
Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility.
Chan et al., Newcastle, Australia. In Am J Physiol Cell Physiol, 2013
The degree of phosphorylation of myosin light chain 20 (MLC20) is a major determinant of force generation in smooth muscle.
Myosin regulatory light chain diphosphorylation slows relaxation of arterial smooth muscle.
Walsh et al., Calgary, Canada. In J Biol Chem, 2012
Findings conclude that phosphorylation at Thr(18) decreases the rates of LC(20) dephosphorylation and smooth muscle relaxation compared with LC(20) phosphorylated exclusively at Ser(19).
Phosphorylation of myosin II regulatory light chain controls its accumulation, not that of actin, at the contractile ring in HeLa cells.
Hosoya et al., Hiroshima, Japan. In Exp Cell Res, 2012
phosphorylated MRLC temporally controls its own accumulation, but not that of actin, in cultured mammalian cells.
Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during cytokinesis.
Hosoya et al., Hiroshima, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that 2P-MRLC has a role different from that of 1P-MRLC at the midzone, and is not a subunit of myosin II.
Analysis of the role of Ser1/Ser2/Thr9 phosphorylation on myosin II assembly and function in live cells.
Egelhoff et al., Cleveland, United States. In Bmc Cell Biol, 2010
The study data show that manipulation of the activation sites (Thr18/Ser19) significantly alters myosin II function in a number of these assays while manipulation of the putative inhibitory sites (Ser1/Ser2/Thr9) does not.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi.
Kohama et al., Maebashi, Japan. In Biochem Biophys Res Commun, 2008
The kinase activity is mediated by the catalytic domain that phosphorylates the myosin light-chain of 20kDa (MLC20), activating smooth muscle myosin to interact with actin.
Sensitized airway smooth muscle plasticity and hyperreactivity: a review.
Fust et al., Winnipeg, Canada. In Can J Physiol Pharmacol, 2007
Nevertheless, we did find that content and total activity of smooth muscle myosin light chain kinase (smMLCK) and the abundance of its message were greater; this would explain the increased MLC20 phosphorylation.
Signaling for contraction and relaxation in smooth muscle of the gut.
Murthy, Richmond, United States. In Annu Rev Physiol, 2005
Phosphorylation of Ser19 on the 20-kDa regulatory light chain of myosin II (MLC20) by Ca2+/calmodulin-dependent myosin light-chain kinase (MLCK) is essential for initiation of smooth muscle contraction.
Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles.
Biancani et al., Providence, United States. In Am J Physiol Gastrointest Liver Physiol, 2005
The steps linking activation of PKC to myosin light chain (MLC20) phosphorylation and contraction, however, have not been clearly defined for LES, Eso, or other smooth muscles.
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