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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interleukin 17F

mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, IL-21, CAN, Interleukin-6, HAD
Papers on mL-1
Self-Enhanced Electrochemiluminescence Nanorods of Tris(bipyridine) Ruthenium (II) Derivative and Its Sensing Application for detection of N-acetyl-β-D-glucosaminidase.
Yuan et al., In Anal Chem, Feb 2016
Based on sandwiched immunoreactions, a simple and sensitive "signal-on" immunosensor is constructed for the detection of N-acetyl-β-D-glucosaminidase (NAG), a biomarker of diabetic nephropathy, with excellent linear in concentrations varying from 1 ng mL-1 to 0.5 pg mL-1 and a detection limit of 0.17 pg mL-1.
Cytotoxicityof Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity.
Hwu et al., Taiwan. In Chemistry, Feb 2016
Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 is with higher cytotoxicity of ~30 g mL-1.
Proinflammatory T cells and IL-17 stimulate osteoblast differentiation.
Alblas et al., Utrecht, Netherlands. In Bone, Feb 2016
IL-17 A and IL-17F, their main proinflammatory cytokines, similarly exhibited strong osteogenic effects when exposed directly to MSCs.
[Abnormal expression of IL- 23/IL- 17 axis in peripheral blood of 45 patients with primary immune thrombocytopenia].
Wu et al., Suzhou, China. In Zhonghua Xue Ye Xue Za Zhi, Jan 2016
METHODS: The real-time quantitative reverse transcription-polymerase chain reaction(RT-PCR)was used to determine the expression of IL-23p19, p40, p35, IL-23R, IL-12Rβ1, IL-12Rβ2, IL-17A, IL-17F mRNA in the peripheral blood of 45 ITP patients and 30 healthy controls.
Targeting Th17 Effector Cytokines for the Treatment of Autoimmune Diseases.
Yang et al., Cambridge, United States. In Arch Immunol Ther Exp (warsz), Dec 2015
The pathogenic function of Th17 cells results from their production of Th17 effector cytokines, namely IL-17 (or IL-17A), IL-17F, IL-22 and IL-26.
IL-17 polymorphisms and asthma risk: a meta-analysis of 11 single nucleotide polymorphisms.
Li et al., Ningbo, China. In J Asthma, Dec 2015
OBJECTIVE: There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Dixit et al., San Francisco, United States. In Nature, Mar 2015
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases.
The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis.
Du et al., Beijing, China. In Drug Des Devel Ther, 2014
The IL-17A and IL-17F are two important members of IL-17 family.
The Evolving View of IL-17-Mediated Immunity in Defense Against Mucocutaneous Candidiasis in Humans.
Maródi et al., Debrecen, Hungary. In Int Rev Immunol, 2014
Inborn errors of immunity affecting IL-17+ T cell differentiation have recently been defined, such as deficiencies of signal transducer and activator of transcription (STAT)3, STAT1, IL-12Rβ1 and IL-12p40, and caspase recruitment domain 9. Impaired receptor-ligand coupling was identified in patients with IL-17F and IL-17 receptor A (IL17RA) deficiency and autoimmune polyendocrine syndrome (APS) type 1. Mutation in the nuclear factor kappa B activator (ACT) 1 was described as a cause of impaired IL-17R-mediated signaling.
Targeting IL-17 and IL-23 in Immune Mediated Renal Disease.
Kitching et al., Australia. In Curr Med Chem, 2014
Th17 cells are a subset of Th cells, characterized by the production of the inflammatory cytokines interleukin (IL)-17A (IL-17A) and IL-17F, which bind to a receptor complex comprised of IL-17RA and IL-17RC subunits.
Association of interleukin-17 gene polymorphisms and Helicobacter pylori infection with gastric cancer susceptibility: a cumulative and comprehensive meta-analysis.
Hu et al., Shiyan, China. In Int J Clin Exp Med, 2014
METHODS: PubMed, Embase, CNKI and Wanfang databases were researched on the associations between IL-17A rs2275913G>A, rs3748067C>T and IL-17F rs763780 T>C and gastric cancer risk.
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
Xu et al., Ann Arbor, United States. In Nat Med, 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
Anticytokine autoantibody-associated immunodeficiency.
Browne, Bethesda, United States. In Annu Rev Immunol, 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Casanova et al., New York City, United States. In Immunity, 2013
Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic mucocutaneous candidiasis (CMC).
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Rawlings et al., Córdoba, Argentina. In Nat Immunol, 2013
With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
Fuke et al., Hachiōji, Japan. In Gene, 2012
IL17F gene polymorphism 7488T>C influences bone mineral density.
Interleukin-33 induces interleukin-17F in bronchial epithelial cells.
Hizawa et al., Tsukuba, Japan. In Allergy, 2012
data suggest that the IL-33/IL-17F axis is involved in allergic airway inflammation
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer.
Pang et al., Harbin, China. In Plos One, 2011
Results suggested that single-nucleotide polymorphisms (SNPs) in IL-17A but not IL-17F were associated with the risk of breast cancer.
A protective role by interleukin-17F in colon tumorigenesis.
Dong et al., Wuhan, China. In Plos One, 2011
Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis
[Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease].
Efremov et al., In Eksp Klin Gastroenterol, 2010
Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease
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