Structure of Mycobacterium smegmatis Eis in complex with paromomycin.
Seoul, South Korea. In Acta Crystallogr Sect F Struct Biol Commun, 2014
Both Mtb Eis and Msm Eis are active as aminoglycoside acetyltransferases, while only Mtb Eis functions as an N(ℇ)-acetyltransferase to acetylate Lys55 of dual-specificity protein phosphatase 16 (DUSP16)/mitogen-activated protein kinase phosphatase 7 (MKP-7), leading to the suppression of host immune responses.
miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.
Toronto, Canada. In Cell Death Dis, 2013
We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1α, and downregulating mTOR, c-myc, cyclin D1, and JNK.