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Midline 1

Midline, MID1
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, LIP, V1a
Papers on Midline
The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.
Torres et al., Los Angeles, United States. In Cell Rep, Feb 2016
Mid1 and Mid2 are ubiquitin ligases that regulate microtubule dynamics and whose mutation is associated with X-linked developmental disorders.
Fetal Development of Human Oral Epithelial Pearls With Special Reference to Their Stage-Dependent Changes in Distribution.
Cho et al., In Cleft Palate Craniofac J, Feb 2016
RESULTS: The upper jaw contained more than 20 midline and more than 60 lateral pearls greater than 20 μm in diameter, whereas the lower jaw contained fewer than 30 pearls of the same size.
Assessment of Wound Complications after Bulbar Urethroplasty: the Impact of a Lambda Perineal Incision.
Rourke et al., Edmonton, Canada. In Urology, Feb 2016
Risk factors for wound complications were evaluated using univariable and multivariable analysis; patient age, positive preoperative urine culture, Charlson Comorbidity Index ≥ 2, diabetes, body mass index ≥35, smoking, and incision type (Lambda perineal incision (LPI) vs. Midline Perineal Incision (MPI)).
Influence of the Cortical Midline Structures on Moral Emotion and Motivation in Moral Decision-Making.
Glover et al., Stanford, United States. In Behav Brain Res, Feb 2016
UNASSIGNED: The present study aims to examine the relationship between the cortical midline structures (CMS), which have been regarded to be associated with selfhood, and moral decision making processes at the neural level.
Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.
Zou et al., Guangzhou, China. In Mol Genet Genomic Med, Jan 2016
BACKGROUND: Opitz syndrome (OS) is a genetic disorder that affects mainly the development of midline structures, including the craniofacial region, embryonic heart, and urogenital system.
Intrapericardial NUT Midline Carcinoma: Unusual Presentation of a Rare Tumor and Literature Review with Management Considerations.
Polimenakos et al., Augusta, United States. In Pediatr Cardiol, Jan 2016
UNASSIGNED: Rearrangements in the nuclear protein in testis (NUT) gene cause carcinomas that represent a rare but aggressive tumor type that often present at advanced stages in midline structures.
Management of Midline Facial Clefts.
Khatri et al., Bhubaneshwar, India. In J Maxillofac Oral Surg, Dec 2015
Median or midline facial clefts are rare anomalies of developmental origin, etiology of whose occurrence is still unknown precisely.
The MID1 protein is a central player during development and in disease.
Krauss et al., Mainz, Germany. In Front Biosci, Dec 2015
Loss-of-function mutations in the MID1 gene cause a rare monogenic disorder, Opitz BBB/G syndrome (OS), which is characterized by malformations of the ventral midline.
Coenzyme Q10 for Patients with Parkinson's disease: A Systematic Review and Meta-analysis.
Rashad et al., Az Zaqāzīq, Egypt. In Cns Neurol Disord Drug Targets, Dec 2015
A computer literature search for (PubMed, EBSCO, Web of science and Ovid Midline) was carried out.
Midline Cleft Lip and Bifid Nose Deformity: Description, Classification, and Treatment.
Holmes et al., Melbourne, Australia. In J Craniofac Surg, Nov 2015
BACKGROUND: Midline facial clefts are rare and challenging deformities caused by failure of fusion of the medial nasal prominences.
United in diversity: mechanosensitive ion channels in plants.
Haswell et al., Saint Louis, United States. In Annu Rev Plant Biol, 2014
Three families of plant MS ion channels have been identified: the MscS-like (MSL), Mid1-complementing activity (MCA), and two-pore potassium (TPK) families.
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
Mattes et al., Newcastle, Australia. In Nat Med, 2013
Here we show that, after exposure to house dust mite (HDM) or rhinovirus infection, the E3 ubiquitin ligase midline 1 (MID1) is upregulated in mouse bronchial epithelium.
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
Schweiger et al., Berlin, Germany. In J Biol Chem, 2011
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
Control of mTORC1 signaling by the Opitz syndrome protein MID1.
Chiang et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2011
mTORC1 signaling as a downstream pathway regulated by the MID1/PP2A axis, suggesting that mTORC1 plays a key role in Opitz syndrome pathogenesis.
Hypospadias associated with hypertelorism, the mildest phenotype of Opitz syndrome.
Nordenskjöld et al., Jinan, China. In J Hum Genet, 2011
Our finding suggests that hypospadias associated with hypertelorism is the mildest phenotype in OS caused by MID1 mutations.
Detection and characterization of the in vitro e3 ligase activity of the human MID1 protein.
Massiah et al., Stillwater, United States. In J Mol Biol, 2011
These studies shed light on MID1 E3 ligase activity and show how its three zinc-binding domains can contribute to MID1's overall function.
Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis.
Meroni et al., Napoli, Italy. In J Neurosci, 2010
Thus, lack of Mid1 causes a misspecification of the midbrain/cerebellar boundary that results in an abnormal development of the most anterior cerebellar lobes.
A spatial gradient coordinates cell size and mitotic entry in fission yeast.
Nurse et al., New York City, United States. In Nature, 2009
This network is located at cortical nodes in the middle of interphase cells, and these nodes contain the Cdk1 inhibitor Wee1, the Wee1-inhibitory kinases Cdr1 (also known as Nim1) and Cdr2, and the anillin-like protein Mid1.
Midline carcinoma of children and young adults with NUT rearrangement.
Fletcher et al., Boston, United States. In J Clin Oncol, 2004
All NUT-rearranged carcinomas (NRCs) arose from midline epithelial structures, including the first example arising below the diaphragm.
Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target.
Flanagan et al., Boston, United States. In Cell, 2002
As axons reach the spinal cord midline, EphA2 is among the receptors upregulated on at least some distal axon segments.
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