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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Midkine, MDK
Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis (summary by Reynolds et al., 2004 [PubMed 15197188]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: ACID, Arp2, CAN, HAD, V1a
Papers on Midkine
MDK Protein Overexpression Correlates with the Malignant Status and Prognosis of Non-small Cell Lung Cancer.
Zhang et al., Kunming, China. In Arch Med Res, Dec 2015
BACKGROUND AND AIMS: Midkine (MDK) is a heparin-binding growth factor and is overexpressed in various types of human cancer.
Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain.
Lasek et al., Chicago, United States. In J Neurochem, Nov 2015
Midkine (MDK) is a neurotrophic factor that is over-expressed in the prefrontal cortex of alcoholics.
Pleiotrophin modulates morphine withdrawal but has no effects on morphine-conditioned place preference.
Herradón et al., Madrid, Spain. In Neurosci Lett, Oct 2015
Morphine administration induces an increase in the expression of PTN and Midkine (MK), the only other member of this family of cytokines, in brain areas related with the addictive effects of drug of abuse, like the Ventral Tegmental Area or the hippocampus.
High expression of Midkine (MK) indicates poor prognosis in childhood acute lymphoblastic leukemia.
Tang et al., In Hematology, Oct 2015
UNASSIGNED: Objectives Midkine (MK) expression has been reported to be correlated with the poor prognosis of patients with various tumors.
Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration.
Milanés et al., Murcia, Spain. In Int J Neuropsychopharmacol, Aug 2015
Midkine (MK) and pleiotrophin (PTN) are growth/differentiation cytokines which, similarly to neurotrophins, play an important role in repair, neurite outgrowth, and cell differentiation.
Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area.
Kwekkeboom et al., Rotterdam, Netherlands. In Br J Cancer, Jul 2015
Expression of a comprehensive panel of cancer-testis (MAGE-A1, MAGE-A3/4, MAGE-A10, MAGE-C1, MAGE-C2, NY-ESO-1, SSX-2, sperm protein 17), onco-fetal (AFP, Glypican-3) and overexpressed tumour antigens (Annexin-A2, Wilms tumor-1, Survivin, Midkine, MUC-1) was determined by immunohistochemistry. RESULTS: A higher prevalence of MAGE antigens was observed in patients with hepatitis-B.
Identification of Circulating Biomarker Candidates for Hepatocellular Carcinoma (HCC): An Integrated Prioritization Approach.
Janjua et al., Islamabad, Pakistan. In Plos One, 2014
Finally, interactome analysis of these proteins with midkine (MDK), dickkopf-1 (DKK-1), current standard HCC biomarker alpha-fetoprotein (AFP), its interacting partners in conjunction with HCC-specific circulating and liver deregulated miRNAs target filtration highlighted seven novel statistically significant putative biomarkers including complement component 8, alpha (C8A), mannose binding lectin (MBL2), antithrombin III (SERPINC1), 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), alcohol dehydrogenase 6 (ADH6), beta-ureidopropionase (UPB1) and cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6).
Wnt/β-catenin up-regulates Midkine expression in glioma cells.
Chen et al., Kaifeng, China. In Int J Clin Exp Med, 2014
Midkine, also known as neurite growth-promoting factor 2 (NEGF2), plays an important role in cell proliferation, apoptosis and differentiation.
Midkine and Pleiotrophin in the Treatment of Neurodegenerative Diseases and Drug Addiction.
Herradón et al., Madrid, Spain. In Recent Pat Cns Drug Discov, 2014
Pleiotrophin (PTN) and Midkine (MK) are neurotrophines with documented protective actions in experimental models of neurodegenerative diseases and beneficial effects on toxicity and addictive behaviours related to drug abuse.
Blood-based lung cancer biomarkers identified through proteomic discovery in cancer tissues, cell lines and conditioned medium.
Ruben et al., Alameda, United States. In Clin Proteomics, 2014
An 8-marker model was developed (TFPI, MDK, OPN, MMP2, TIMP1, CEA, CYFRA 21-1, SCC) which accurately distinguished subjects with lung cancer (n = 50) from high risk smokers (n = 50) in an independent validation study (AUC = 0.775).
The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.
Schinke et al., Hamburg, Germany. In Plos One, 2014
A comparison between Ptprz1-heterozygous and Ptprz1-deficient cultures further revealed that the latter ones displayed increased proliferation, a higher abundance of tyrosine-phosphorylated proteins and resistance towards the influence of the growth factor Midkine.
Perspectives on a combined test of multi serum biomarkers in China: towards screening for and diagnosing hepatocellular carcinoma at an earlier stage.
Zhang et al., Chon Buri, Thailand. In Drug Discov Ther, 2014
During the past ten years, the research on the clinical usefulness of novel serum biomarkers of des-γ-carboxy-prothrombin (DCP), Dickkopf-1 (DKK1) and Midkine (MDK) in early HCC detection for Chinese patients found that the novel serum biomarker can complete the measurement of α-fetoprotein (AFP) in the diagnosis process of HCC, particularly for the patient with negative AFP with/or at an early stage.
Midkine in repair of the injured nervous system.
Ikutomo et al., Kagoshima, Japan. In Br J Pharmacol, 2014
UNLABELLED: Midkine (MK) is a growth factor with neurotrophic and neurite outgrowth activities.
Midkine in nephrogenesis, hypertension and kidney diseases.
Sato et al., Nagoya, Japan. In Br J Pharmacol, 2014
UNLABELLED: Midkine (MK; K; gene abbreviation, Mdk: mus musculus, MDK: homo sapiens) is a multifunctional heparin-binding growth factor that regulates cell growth, survival and migration as well as anti-apoptotic activity in nephrogenesis and development.
The role of midkine in skeletal remodelling.
Amling et al., Ulm, Germany. In Br J Pharmacol, 2014
The growth factor midkine (Mdk) plays a key role in bone remodelling and it is expressed during bone formation and fracture repair.
Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis.
Walzog et al., München, Germany. In Am J Physiol Heart Circ Physiol, 2012
Identify endothelial cells as the source of soluble midkine in the vascular system during hypoxia and defined midkine as a pivotal player of angiogenesis during ischemia in nonmalignant tissue.
Novel functional proteins interact with midkine in hepatic cancer cells.
Zheng et al., Hangzhou, China. In Hepatobiliary Pancreat Dis Int, 2012
Identify midkine interacting proteins in liver tumor cells.
Plasma levels of midkine (neurite growth-promoting factor 2) are not associated with plasma fibrinolytic potential or risk of venous thrombosis.
Rosendaal et al., In J Thromb Haemost, 2012
Letter: Plasma levels of midkine are not associated with plasma fibrinolytic potential or risk of venous thrombosis.
Expression of midkine and vascular endothelial growth factor in gastric cancer and the association of high levels with poor prognosis and survival.
Lu et al., Putian, China. In Mol Med Report, 2012
Expression of MK and VEGF is increased in gastric cancer and increased expression is closely correlated with poor prognosis and survival
Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition.
Rohrer et al., Frankfurt am Main, Germany. In Development, 2011
Results demonstrate that the extent and timing of sympathetic neurogenesis is controlled by Midkine and Alk signaling.
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