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Microphthalmia-associated transcription factor

Microphthalmia-Associated Transcription Factor, MITF
This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: tyrosinase, CAN, V1a, TRPC1, ERK
Papers on Microphthalmia-Associated Transcription Factor
Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup.
Bianchi-Scarrà et al., Genova, Italy. In J Am Acad Dermatol, Feb 2016
OBJECTIVE: We sought to determine the CDKN2A/CDK4/microphthalmia-associated transcription factor mutation rate among Italian patients with MPM to appropriately direct genetic counseling regardless of family history.
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
Botas et al., Houston, United States. In Autophagy, Feb 2016
In mammals, TFEB and other members of the MiTF-TFE family of transcription factors control this network.
Clinical and genetic investigation of families with type II Waardenburg syndrome.
Wu et al., Changsha, China. In Mol Med Report, Feb 2016
The coding sequences of paired box 3 (PAX3), microphthalmia‑associated transcription factor (MITF), sex‑determining region Y‑box 10 (SOX10) and snail family zinc finger 2 (SNAI2) were analyzed by polymerase chain reaction and DNA sequencing.
Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling.
Shibahara et al., Sendai, Japan. In Biochem Biophys Res Commun, Feb 2016
UNASSIGNED: Microphthalmia-associated transcription factor (MITF) is a key regulator of differentiation of melanocytes and retinal pigment epithelial cells, but it also has functions in non-pigment cells.
Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders.
Kang et al., Suwŏn, South Korea. In J Invest Dermatol, Jan 2016
It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via β-catenin signaling.
MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma.
Avan et al., Mashhad, Iran. In Eur J Cancer, Jan 2016
let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes such as NRAS, microphthalmia-associated transcription factor, receptor tyrosine kinase c-KIT, AP-2 transcription factor, etc.
Spitz nevus arising in the eyelid of a teenager.
Yoon et al., Philadelphia, United States. In Surv Ophthalmol, Nov 2015
HMB-45, MART-1, and microphthalmia-associated transcription factor were all positive and established the melanocytic nature of the benign tumor.
Update in genetic susceptibility in melanoma.
Puig et al., Barcelona, Spain. In Ann Transl Med, Sep 2015
Furthermore variants in melanocortin 1 receptor (MC1R) and microphthalmia-associated transcription factor (MITF) give a moderately increased risk to develop melanoma.
The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.
De Robertis et al., Los Angeles, United States. In Pharmacol Res, Sep 2015
MITF, a melanoma oncogene member of the microphthalmia family of transcription factors (MiT), was recently found to contain novel GSK3 phosphorylation sites and to be stabilized by Wnt.
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Bardeesy et al., Boston, United States. In Nature, Sep 2015
In human PDA cells, the MiT/TFE proteins--MITF, TFE3 and TFEB--are decoupled from regulatory mechanisms that control their cytoplasmic retention.
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Seshagiri et al., San Francisco, United States. In Nat Genet, 2015
Using RNA sequencing, we identified previously unreported gene fusions, including ACTG1-MITF fusion.
Melanotic oncocytic metaplasia of the nasopharynx: a case report with a focus on immunohistochemical analyses and literature review.
Nameki et al., Tokyo, Japan. In Int J Clin Exp Pathol, 2014
Upon immunohistochemical examination, melanocytes displayed reactivity for 3 out of 4 melanocytic markers; immunopositivity for S-100 protein, Melan-A, and MITF and immunonegativity for HMB-45 was observed.
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.
Soengas et al., Madrid, Spain. In Cancer Cell, 2014
Importantly, RAB7 levels and function were independent of MITF, the best-characterized melanocyte lineage-specific transcription factor.
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
Garraway et al., Cambridge, United States. In Nature, 2014
Expression of transcription factors activated downstream of MAP kinase and cAMP pathways also conferred resistance, including c-FOS, NR4A1, NR4A2 and MITF.
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.
Steingrimsson et al., Iceland. In Cell, 2013
The allele associated with this pigmentation phenotype impairs binding of the TFAP2A transcription factor that, together with the melanocyte master regulator MITF, regulates activity of the enhancer.
Mechanism of Mitf inhibition and morphological differentiation effects of hirsein A on B16 melanoma cells revealed by DNA microarray.
Isoda et al., Tsukuba, Japan. In J Dermatol Sci, 2012
Hirsein A can downregulate Mitf expression and promote cell differentiation in B16 melanoma cells.
SOX2 modulates levels of MITF in normal human melanocytes, and melanoma lines in vitro.
Terskikh et al., In Pigment Cell Melanoma Res, 2012
results suggest that SOX2 is required for the endogenous levels of MITF in hESC-NC and normal human melanocytes in vitro
Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF.
Piguet et al., Genève, Switzerland. In Pigment Cell Melanoma Res, 2012
BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype.
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.
Arnheiter et al., Bethesda, United States. In Plos Genet, 2012
in the retinal pigment epithelium(RPE) , PAX6 cooperates with either one (or both) of two related RPE transcription factors, MITF and TFEC, to suppress extracellular signals that in the normal retina induce a signaling cascade promoting retina formation.
YY1 regulates melanocyte development and function by cooperating with MITF.
Fisher et al., Boston, United States. In Plos Genet, 2011
These studies reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)-a general mechanism which may confer tissue-specific gene expression in multiple lineages
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