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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Human immunodeficiency virus type I enhancer binding protein 2

MIBP1, Schnurri-2, MBP2, Shn-2, HIVEP2
Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM, Apr 2006] (from NCBI)
Top mentioned proteins: Schnurri, MBP, CAN, c-Myc, ACID
Papers on MIBP1
Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice.
Brownell et al., United States. In Neurosci Lett, Dec 2015
Schnurri-2 (Shn-2) knockout (KO) mice have been proposed as a preclinical neuroinflammatory schizophrenia model.
Loss-of-function variants in HIVEP2 are a cause of intellectual disability.
Naidu et al., Baltimore, United States. In Eur J Hum Genet, Aug 2015
Applying WES to patients with ID or global developmental delay at different centers, we identified three individuals with distinct de novo variants in HIVEP2 (human immunodeficiency virus type I enhancer binding protein), which belongs to a family of zinc-finger-containing transcriptional proteins involved in growth and development.
The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis.
Treon et al., Boston, United States. In Blood, 2014
Validated gene losses due to CNAs involved PRDM2 (93%), BTG1 (87%), HIVEP2 (77%), MKLN1 (77%), PLEKHG1 (70%), LYN (60%), ARID1B (50%), and FOXP1 (37%).
Identification and characterization of human MIBP1 gene in glioma cell differentiation.
Chen et al., Tianjin, China. In J Mol Neurosci, 2014
After it was cloned and sequenced, the 505-bp fragment was identified as the MIBP1 (c-myc intron-binding protein 1) gene, also named Hivep2/MBP-2/Schnurri-2.
Lactobacillus acidophilus L-92 Cells Activate Expression of Immunomodulatory Genes in THP-1 Cells.
Yamamoto et al., Sagamihara, Japan. In Biosci Microbiota Food Health, 2013
In the early phase of L-92 treatment, various transcription regulator genes, such as, NFkB1, NFkB2, JUN, HIVEP2 and RELB, and genes encoding chemokines and cytokines, such as CCL4, CXCL11, CCL3 and TNF, were upregulated.
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.
Miyakawa et al., Japan. In Neuropsychopharmacology, 2013
Schnurri-2 (Shn-2), an nuclear factor-κB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which have been shown to harbor common variant single-nucleotide polymorphisms associated with schizophrenia.
A new, modular mass calibrant for high-mass MALDI-MS.
Zenobi et al., Zürich, Switzerland. In Anal Chem, 2013
Introduction of two specific recognition sites into the primary sequence of the polyprotein allows for the selective cleavage of MBP3 into MBP and MBP2.
Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma and adenocarcinoma.
Zheng et al., Chongqing, China. In Mol Med Report, 2012
An immunohistochemical streptavidin-peroxidase (SP) method was used to examine the expression of MBP2, TLR4, TLR3 and COX2 in 20 colorectal juvenile polyps and 15 colorectal polyps of hamartomatous polyposis obtained from children, and 20 colorectal adenomas and 20 colorectal adenocarcinomas obtained from adults.
Genome-wide repression of NF-κB target genes by transcription factor MIBP1 and its modulation by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase.
Tahira et al., Fukuoka, Japan. In J Biol Chem, 2012
a 154-amino acid region of MIBP1 was necessary for its O-GlcNAc transferase binding and O-GlcNAcylation.
Murine Schnurri-2 controls natural killer cell function and lymphoma development.
Nakayama et al., Chiba, Japan. In Leuk Lymphoma, 2012
Shn-2 plays an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.
Special AT-rich sequence-binding protein 2 and its related genes play key roles in the differentiation of MC3T3-E1 osteoblast like cells.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
In addition, using the GeneSpringGX 7.3 program to compare the identified genes expressed in SATB2-overexpresed cells with untreated control, we found several unique genes closely associated with osteoblast differentiation, including SOX2, MBP2, WNT11 and MEN1 (up-regulated genes), and ILK, FGF23, FGFR2, and SNAI1 (down-regulated genes).
Dampening of death pathways by schnurri-2 is essential for T-cell development.
Glimcher et al., Boston, United States. In Nature, 2011
repression of T cell receptor-induced death pathways is critical for proper interpretation of positive selecting signals in vivo; identification of schnurri-2 (Shn2; or Hivep2) as a crucial death dampener
Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy.
Noda et al., Tokyo, Japan. In J Cell Physiol, 2011
Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss.
Memory Th1/Th2 cell generation controlled by Schnurri-2.
Kimura et al., Chiba, Japan. In Adv Exp Med Biol, 2009
Results indicate that Schnurri-2-mediated repression of NF-kappaB is required for cell survival and the successful generation of memory Th1/Th2 cells.
Murine Schnurri-2 is required for positive selection of thymocytes.
Ishii et al., Tsukuba, Japan. In Nat Immunol, 2001
We show here that mice lacking the transcription factor Schnurri-2 (Shn-2), a large metal-finger protein, had severely defective positive selection of CD4+ and CD8+ cells.
A novel human homolog of eosinophil major basic protein.
Gleich et al., Rochester, United States. In Immunol Rev, 2001
Chromosome 11 contains the genes for human MBP1 (hMBP1) and a second novel MBP, hMBP2, in the centromere to 11q12 region.
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