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Glutathione S-transferase, pi 2

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: GST, ACID, CAN, microsomal glutathione S-transferase, SOD
Papers on MGST3
Soyabean glycinin depresses intestinal growth and function in juvenile Jian carp (Cyprinus carpio var Jian): protective effects of glutamine.
Feng et al., Chengdu, China. In Br J Nutr, Dec 2015
However, dietary glycinin exposure decreased both the activity and mRNA levels of nine isoforms of glutathione-S-transferase (GST) (α, μ, π, ρ, θ, κ, mGST1, mGST2 and mGST3), indicating toxicity to this enzyme activity and corresponding isoform gene expressions.
Characterization of glutathione-S-transferases in zebrafish (Danio rerio).
Smital et al., Novi Sad, Serbia. In Aquat Toxicol, 2015
Affinity toward CDNB varied from 0.28 mM (Gstp2) to 3.69 mM (Gstm3), while affinity toward MCB was in the range of 5 μM (Gstt1a) to 250 μM (Gstp1).
Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration.
Corlu et al., Rennes, France. In Cell Death Dis, 2014
Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation.
PmMGST3, a novel microsomal glutathione S-transferase gene in the dinoflagellate Prorocentrum minimum, is a potential biomarker of oxidative stress.
Ki et al., Seoul, South Korea. In Gene, 2014
In this study, we evaluated a novel microsomal glutathione S-transferase3 (MGST3) gene from the dinoflagellate Prorocentrum minimum, and examined its expression pattern in response to copper-and nickel-induced stresses.
Mice lacking three Loci encoding 14 glutathione transferase genes: a novel tool for assigning function to the GSTP, GSTM, and GSTT families.
Koller et al., Chapel Hill, United States. In Drug Metab Dispos, 2014
In addition, we delete two Gstp genes on chromosome 19 as well as a third related gene located 15 kb telomeric to Gstp1 and Gstp2, which we identify as a potential new member of this gene family.
Keap1 inhibition attenuates glomerulosclerosis.
Matsusaka et al., Tokyo, Japan. In Nephrol Dial Transplant, 2014
Real-time PCR revealed that Keap1 KD upregulated Nrf2 target genes, including Gclc, Gclm, Gstp1, Gstp2 and Nqo1 in the glomerulus.
Molecular cloning, characterization and positively selected sites of the glutathione S-transferase family from Locusta migratoria.
Zhang et al., Taiyuan, China. In Plos One, 2013
We assigned the 28 cytosolic GSTs into 6 classes--sigma, epsilon, delta, theta, omega and zeta, and the 4 microsomal GSTs into 2 subclasses--insect and MGST3.
Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.
Hager et al., Manchester, United Kingdom. In Bmc Genomics, 2013
We first use a novel cross-species, comparative analysis using mouse and human genetic data to identify a candidate gene, MGST3, associated with adult hippocampus size in both systems.
Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function.
Health ABC study et al., Ithaca, United States. In Free Radic Biol Med, 2013
Statistically significant gene-by-smoking interactions were observed for variants in two genes in European Americans: the minor allele of rs2297765 in mGST3 attenuated the accelerated decline in FEV₁/FVC in smokers by 0.45% per year (P = 1.13 × 10(-4)); for participants with greater baseline smoking pack-years, the minor allele of rs2073192 in IDH3B was associated with an accelerated decline in FEV₁/FVC (P = 2.10 × 10(-4)).
Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque.
Yamazaki et al., Kainan, Japan. In Drug Metab Dispos, 2013
Among the microsomal GSTs (MGSTs) in humans, MGST1, MGST2, and MGST3 are involved in detoxification; however, MGSTs have not been fully investigated in cynomolgus macaque, an important primate species widely used in drug metabolism and toxicity studies.
Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish.
Lv et al., Harbin, China. In Aquat Toxicol, 2013
Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Bcl-2, in response to oxidative damage, such as Nqo1, and related to antioxidant response element such as Gstp2 were significantly down-regulated in the nano-ZnO treatment groups.
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Hayes et al., Dundee, United Kingdom. In Drug Metab Rev, 2011
Members of the cytosolic class Alpha, Mu, Pi and Theta GST, and also certain microsomal transferases (MGST2 and MGST3), are up-regulated by a diverse spectrum of foreign compounds typified by phenobarbital, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pregnenolone-16α-carbonitrile, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, β-naphthoflavone, butylated hydroxyanisole, ethoxyquin, oltipraz, fumaric acid, sulforaphane, coumarin, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole, 12-O-tetradecanoylphorbol-13-acetate, dexamethasone and thiazolidinediones.
Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.
Wolf et al., Dundee, United Kingdom. In Proc Natl Acad Sci U S A, 2010
Apc(Min/+)Gstp1/p2(-/-) (Gstp-null Apc(Min)) mice had a 6-fold increase in colon adenoma incidence, and a 50-fold increase in colorectal adenoma multiplicity, relative to Gstp-wt Apc(Min).
Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre.
Glei et al., Jena, Germany. In Mutat Res, 2009
In LT97 adenoma cells, GSTM3, GSTT2, and MGST3 were induced, whereas GSTA2, GSTT2, and catalase (CAT) were elevated in primary colon cells.
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke.
Bhatnagar et al., Louisville, United States. In Am J Physiol Heart Circ Physiol, 2009
GSTP protects against the endothelial dysfunction induced by tobacco smoke exposure and that this protection may be related to the detoxification of acrolein or other related cigarette smoke constituents.
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.
Miyano et al., Japan. In Nature, 2007
In contrast with MGST2 and MGST3 (refs 15, 16), LTC4S does not conjugate glutathione to xenobiotics.
Therapeutic options for 5-lipoxygenase inhibitors.
Steinhilber et al., Tübingen, Germany. In Pharmacol Ther, 2006
LTA(4) can then be converted into LTB(4) by LTA(4) hydrolase or into LTC(4) by LTC(4) synthase and the LTC(4) synthase isoenzymes MGST2 and MGST3.
Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus.
Trevor Young et al., Toronto, Canada. In Brain Res, 2006
The downregulation of Gstp2 may induce an increase of oxidative damage in the pyramidal cells of the CA1 and CA3 regions and granular layer of the dentate gyrus, leading to structural and functional damage.
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
Freeman et al., Buffalo, United States. In Free Radic Biol Med, 2005
The glutathione S-transferase, pi 2 was represented by two EST clones with similar levels of downregulation.
Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice.
Tew et al., Philadelphia, United States. In Int J Cancer, 2005
These results suggest that GSTpi may play a protective role in the development of spontaneous tumors.
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