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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Glutamate receptor, metabotropic 8

mGluR, mGluR8
metabotropic glutamate receptor that may be involved in synaptic transmission [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: metabotropic glutamate receptor, CAN, mGluR1, ACID, V1a
Papers on mGluR
Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials.
von Raison et al., Chicago, United States. In Sci Transl Med, Feb 2016
Therefore, under the conditions of our study, we could not confirm the mGluR theory of FXS nor the ability of the methylation state of the FMR1 promoter to predict mavoglurant efficacy.
Pérez-Acevedo et al., Cayey, Puerto Rico. In Behav Brain Res, Feb 2016
Infusion of (S)-3,5-Dihydroxyphenylglycine (DHPG), a group I mGluR agonist, into the basolateral amygdala, a region involved in anxiety-responses, statistically increased the number of shocks in OVX, but not OVX+EB female rats at 0.1, nor at 1.0μM.
Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors.
Papatheodoropoulos et al., Pátrai, Greece. In Neuroscience, Feb 2016
These findings show that the NMDAR-dependent modulation of fundamental parameters of the local neuronal network, by mGluR, A2AR and CB1R, markedly differs between DH and VH.
New targets for rapid antidepressant action.
Zarate et al., Bethesda, United States. In Prog Neurobiol, Jan 2016
This article reviews the clinical evidence supporting the use of novel glutamate receptor modulators with direct affinity for cognate receptors: (1) non-competitive NMDA receptor antagonists (ketamine, memantine, dextromethorphan, AZD6765); (2) subunit (GluN2B)-specific NMDA receptor antagonists (CP-101,606/traxoprodil, MK-0657); (3) NMDA receptor glycine-site partial agonists (GLYX-13); and (4) metabotropic glutamate receptor (mGluR) modulators (AZD2066, RO4917523/basimglurant).
Signal integration by Ca(2+) regulates intestinal stem-cell activity.
Jasper et al., Novato, United States. In Nature, Jan 2016
The metabotropic glutamate receptor (mGluR) is required in ISCs for this response, and for an associated modulation of cytosolic Ca(2+) oscillations that results in sustained high cytosolic Ca(2+) concentrations.
The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder.
Hakonarson et al., Seattle, United States. In Sci Rep, Dec 2015
This study sought to determine whether mGluR Copy Number Variants (CNV's) were overrepresented in children with syndromic ASD and if mGluR "second hit" confers additional risk for ASD in 22q11.2
Conformational dynamics of a class C G-protein-coupled receptor.
Isacoff et al., Berkeley, United States. In Nature, Sep 2015
Crystal structures of isolated mGluR LBD dimers led to the suggestion that activation also involves a reorientation of the dimer interface from a 'relaxed' to an 'active' state, but the relationship between ligand binding, LBD closure and dimer interface rearrangement in activation remains unclear.
Synaptic-like vesicles and candidate transduction channels in mechanosensory terminals.
Bewick, Aberdeen, United Kingdom. In J Anat, Aug 2015
The glutamate activates a highly unusual glutamate receptor linked to phospholipase D activation, which we have termed the PLD-mGluR.
Modulating mechanosensory afferent excitability by an atypical mGluR.
Watson, Aberdeen, United Kingdom. In J Anat, Aug 2015
The secreted glutamate activates a highly unusual metabotropic glutamate receptor (mGluR) to modulate the firing rate (spindles) and SLV recycling (lanceolates).
Addiction therapy. Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology.
Lüscher et al., Genève, Switzerland. In Science, Mar 2015
We discovered that acute low-frequency DBS, refined by selective blockade of dopamine D1 receptors, mimics optogenetic mGluR-dependent normalization of synaptic transmission.
Cross-talk and regulation between glutamate and GABAB receptors.
Kantamneni, Bradford, United Kingdom. In Front Cell Neurosci, 2014
NMDA, AMPA and mGluR receptors are the major subclasses of glutamate receptors that are involved in excitatory transmission at synapses, mechanisms of activity dependent synaptic plasticity, brain development and many neurological diseases.
Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes.
Ferguson et al., London, Canada. In Mol Brain, 2014
However, the dysregulation of glutamatergic signaling has also been implicated in a number of neurodegenerative diseases including AD. Glutamate acts via both ionotropic glutamate receptors (iGluR) and metabotropic glutamate receptors (mGluR), each of which have been implicated in AD.
Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat.
Leem et al., Seoul, South Korea. In Mediators Inflamm, 2014
When intraplantar ( injection was administered into the L4 dermatome before ES, NMDAR and group-I metabotropic Glu receptor (mGluR) antagonists and group-II mGluR agonist but not AMPA/kainate receptor antagonist prevented ES-induced hypersensitivity.
TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation.
Lee et al., Seoul, South Korea. In Cell, 2012
Diffusion modeling predicts that the fast mode can target neuronal mGluR with peak glutamate concentration of 100 μM, whereas slow mode targets neuronal NMDA receptors at around 1 μM.
Depression of release by mGluR8 alters Ca2+ dependence of release machinery.
Dietrich et al., Bonn, Germany. In Cereb Cortex, 2012
In conclusion, our data identify a mode of presynaptic inhibition which allows mGluR8 to profoundly inhibit vesicle fusion.
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function.
Kim et al., Taejŏn, South Korea. In Nature, 2012
These results suggest that reduced NMDAR function may contribute to the development of ASD-like phenotypes in Shank2(-/-) mice, and mGluR modulation of NMDARs offers a potential strategy to treat ASD.
High affinity group III mGluRs regulate mossy fiber input to CA3 interneurons.
Barrionuevo et al., Pittsburgh, United States. In Hippocampus, 2011
Selective activation of mGluR8 with L(+)-2-amino-4-phosphnobytyric acid decreased the probability of glutamate release from the mossy fiber terminals synapsing onto stratum lacunosum-moleculare interneurons.
mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.
Winder et al., Nashville, United States. In Neuropsychopharmacology, 2011
mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress.
Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways.
Gasparini et al., Trieste, Italy. In J Med Genet, 2011
Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
Enz et al., Erlangen, Germany. In Biochem J, 2011
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
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