Monoglyceride lipase: Structure and inhibitors.
Parma, Italy. In Chem Phys Lipids, Aug 2015
UNASSIGNED: Monoglyceride lipase (MGL), the main enzyme responsible for the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), is an intracellular serine hydrolase that plays critical roles in many physiological and pathological processes, such as pain, inflammation, neuroprotection and cancer.
Chemical probes of endocannabinoid metabolism.
Los Angeles, United States. In Pharmacol Rev, 2013
Anandamide and 2-AG signaling pathways in the nervous system are terminated by enzymatic hydrolysis mediated primarily by the serine hydrolases fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively.