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Lethal giant larvae homolog 1

mgl-1, Hugl-1, LLGL, LLGL1, Hugl, DLG4, Llglh
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MGL, CAN, PSD-95, ACID, HAD
Papers on mgl-1
Hugl-1 inhibits glioma cell growth in intracranial model.
Zhou et al., Xuzhou, China. In J Neurooncol, Oct 2015
Human giant larvae-1(Hugl-1), one human homologue of Drosophila lgl, also has been reported to be involved in the development of some human cancers.
Novel genetic causes for cerebral visual impairment.
de Vries et al., Nijmegen, Netherlands. In Eur J Hum Genet, Oct 2015
In addition, in 11 patients (44%) with CVI, variants in one or more candidate genes were identified (ACP6, AMOT, ARHGEF10L, ATP6V1A, DCAF6, DLG4, GABRB2, GRIN1, GRIN2B, KCNQ3, KCTD19, RERE, SLC1A1, SLC25A16, SLC35A2, SOX5, UFSP2, UHMK1, ZFP30).
Decreased PSD95 expression in medial prefrontal cortex (mPFC) was associated with cognitive impairment induced by sevoflurane anesthesia.
Liang et al., China. In J Zhejiang Univ Sci B, Sep 2015
Postsynaptic density-95 (PSD95, also named DLG4) showed the most significantly decreased expression in mPFC and further investigation indicated that PSD95 expression level was correlated with spatial working memory performance.
Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH).
Albano et al., Novara, Italy. In Exp Mol Pathol, Aug 2015
In mice with NASH, the accumulation of enlarged F4/80(+) cells paralleled with a decline in the expression of the macrophage M1 activation markers iNOS, IL-12 and CXCL10, while the levels of M2 polarization markers arginase-1 and MGL-1 were unchanged.
Proteomic Analysis of Cerebellum in Common Marmoset Exposed to Methylmercury.
Chan et al., Prince George, Canada. In Toxicol Sci, Jul 2015
DLG4: (PSD95) and MIR-19A/MIR-19B were found to be potential key targets leading to the multiple effects of MeHg neurotoxicity.
O'Connor et al., Southampton, United Kingdom. In J Biol Chem, Jul 2015
In C. elegans, three mGluR genes, mgl-1, mgl-2, and mgl-3, are organized into three subgroups, similar to their mammalian counterparts.
Quantitative mass spectrometry measurements reveal stoichiometry of principal postsynaptic density proteins.
Dosemeci et al., Gaithersburg, United States. In J Proteome Res, Jul 2015
Interpretation of PSD protein stoichiometry was achieved as a molar ratio with respect to PSD-95 (SAP-90, DLG4), and subsequently, copy numbers were estimated using a consensus literature value for PSD-95.
[Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats].
Zhu et al., In Fa Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To observe the expression of discs large homolog 4 (DLG4) protein in hippocampus, amygdala and frontal cortex of rats and evaluate postsynaptic density in heroin dependence.
Reduced Expression of Hugl 1 Contributes to the Progression of Lung Squamous Cell Carcinoma.
Iwazaki et al., Isehara, Japan. In Tokai J Exp Clin Med, 2014
Several polarity proteins including atypical protein kinase C (aPKC), Par 6, Par 3, and Lethal giant larvae (Lgl, the human homologues of which are called Hugl 1 and Hugl 2) are localized at the leading edge of migrating cells, and play critical roles during directional migration.
Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development.
Liu et al., Xi'an, China. In Int J Biol Sci, 2014
Furthermore, Lgl plays a role of a tumor suppressor, and the aberrant expression of Hugl, a human homologue of Lgl, contributes to multiple cancers.
Novel drug target identification for the treatment of dementia using multi-relational association mining.
Caberlotto et al., Rovereto, Italy. In Sci Rep, 2014
Among the highly represented kinase family and among the G-protein coupled receptors, DLG4 (PSD-95), and the bradikynin receptor 2 are highlighted also for their proposed role in memory and cognition, as described in previous studies.
Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach.
Fortune et al., Baltimore, United States. In Expert Opin Drug Discov, 2013
EXPERT OPINION: In the genetically informed network, known genes and identified key connecting components, including DLG4 (a developmental gene), PSD-95 (a synaptic scaffolding protein) and PSEN1 (presenilin, a regulator of secretase), conform a group of potential pharmacological targets.
The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins.
Marsh et al., Birmingham, United Kingdom. In Febs J, 2012
However, whether mammalian homologues of DLG (DLG1, DLG2, DLG3 and DLG4) also possess tumour suppressor functions is not known.
Preservation of HUGL-1 expression as a favourable prognostic factor in pancreatic carcinoma.
Galle et al., Düsseldorf, Germany. In Anticancer Res, 2012
Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival
The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration.
Ravid et al., Jerusalem, Israel. In Mol Biol Cell, 2012
Collectively these findings indicate that Lgl1 regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.
Research progress on neurobiology of neuronal nitric oxide synthase.
Zhu et al., Nanjing, China. In Neurosci Bull, 2011
There are primarily 9 nNOS-interacting proteins, including post-synaptic density protein 95 (PSD95), clathrin assembly lymphoid leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and dynein light chain (LC).
Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM.
Baek et al., Seoul, South Korea. In J Biol Chem, 2010
Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression.
Chen et al., Shanghai, China. In Clin Cancer Res, 2009
Results provide the first evidence that Hugl-1 mRNA is frequently mutated by aberrant splicing exclusively in HCC, which may be involved in HCC progression.
Differential regulation of Dlg1, Scrib, and Lgl1 expression in a transgenic mouse model of ocular cancer.
Abitbol et al., Paris, France. In Mol Vis, 2007
This is the first study to demonstrate the involvement of Dlg1, Scrib, and Lgl1 in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.
Alteration of human breast tumor cell membrane functions by chromosome-mediated gene transfer.
Gray et al., In J Supramol Struct, 1978
Transferants MGP-1 and MGL-1 are stable after 18 months and have been characterized on the bases of purine and pyrimidine nucleoside uptake, relative thymidine kinase activities, alkaline phosphatase activities, and hydrocortisone-induced alkaline phosphatase activity.
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