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Microfibrillar-associated protein 4

MFAP4, 36-kDa microfibril-associated glycoprotein, microfibril-associated glycoprotein 4, 36-kD microfibril-associated glycoprotein
This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
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Top mentioned proteins: CD45, fibrillin-1, elastin, MAGP, ACID
Papers on MFAP4
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.
Sorensen et al., Odense, Denmark. In J Biol Chem, Feb 2016
MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.
Sorensen et al., Århus, Denmark. In Arterioscler Thromb Vasc Biol, Jan 2016
Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers in the vascular wall.
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer.
Polenakovic et al., Скопје, Macedonia. In Prostate, Oct 2015
Thirteen of the identified proteins, namely, constituents of the intermediate filaments (KRT8, KRT18, DES), potential tumor suppressors (ARHGAP1, AZGP1, GSTM2, and MFAP4), transport and membrane organization proteins (FABP5, GC, and EHD2), chaperons (FKBP4 and HSPD1) and known cancer marker (NME1) have been associated with prostate and other cancers by numerous proteomics, genomics or functional studies.
Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.
Sorensen et al., Odense, Denmark. In Thorax, Sep 2015
Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein abundant in the lung, whose biological functions remain poorly understood.
Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4.
Sorensen et al., Odense, Denmark. In Am J Physiol Lung Cell Mol Physiol, Jul 2015
Microfibrillar-associated protein 4 (MFAP4) is localized to elastic fibers in blood vessels and the interalveolar septa of the lungs and is further present in bronchoalveolar lavage.
Analysis of disease-associated protein expression using quantitative proteomics—fibulin-5 is expressed in association with hepatic fibrosis.
Sitek et al., Bochum, Germany. In J Proteome Res, Jun 2015
Furthermore, we confirmed the altered expression of microfibril-associated glycoprotein 4 (MFAP4), lumican (LUM), and collagen alpha-1(XIV) chain (COL14A1) in association to hepatic fibrosis.
A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.
Franke et al., Groningen, Netherlands. In Thorax, 2015
Among the most upregulated genes were fibulin-5 (FBLN5), elastin (ELN), latent transforming growth factor β binding protein 2 (LTBP2) and microfibrillar associated protein 4 (MFAP4), all implicated in elastogenesis.
Microfibrillar-Associated Protein 4: A Potential Biomarker for Screening for Liver Fibrosis in a Mixed Patient Cohort.
Sorensen et al., Odense, Denmark. In Plos One, 2014
Microfibrillar-associated protein 4 (MFAP4) is a suggested biomarker for identification of high-risk patients with severe fibrosis stages.
microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest.
Du et al., San Antonio, United States. In Rna Biol, 2014
Our comprehensive investigations on the dissection of the target genes of miR-449a revealed that 3 novel targets- MFAP4, PKP4 and TSEN15 -play important roles in mediating its differentiation-inducing function.
Microfibrillar-associated protein 4: a potential biomarker of chronic obstructive pulmonary disease.
Sorensen et al., Odense, Denmark. In Respir Med, 2014
BACKGROUND: Microfibrillar-associated protein 4 (MFAP4) is a matricellular glycoprotein that co-localises with elastic fibres and is highly expressed in the lungs.
The PROTECCT-M study: a cohort study investigating associations between novel specific biomarkers, patient-related, healthcare system markers and the trajectory of COPD patients treated in primary care.
Halling et al., Odense, Denmark. In Bmc Pulm Med, 2013
The overall aim is to study determinants of exacerbations of COPD treated in primary care and to study, if the prognosis is related to patient-related, healthcare system markers or levels of the potential biomarkers such as microfibrillar-associated protein 4 (MFAP4) and surfactant protein D (SP-D).
Enzyme-linked immunosorbent assay characterization of basal variation and heritability of systemic microfibrillar-associated protein 4.
Sørensen et al., Odense, Denmark. In Plos One, 2012
BACKGROUND: Microfibrillar-associated protein 4 (MFAP4) is a systemic biomarker that is significantly elevated in samples from patients suffering from hepatic cirrhosis.
Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions.
Sorensen et al., Odense, Denmark. In Plos One, 2012
Microfibrillar-associated protein 4 (MFAP4) is located in the extracellular matrix (ECM).
Rare copy number variants contribute to congenital left-sided heart disease.
Andelfinger et al., Montréal, Canada. In Plos Genet, 2012
After stringent filtering, our gene inventory reveals 25 new candidates for LS-CHD pathogenesis, such as SMC1A, MFAP4, and CTHRC1, and overlaps with several known syndromic loci.
Differential gene expression of 36-kDa microfibril-associated glycoprotein (MAGP-36/MFAP4) in rat organs.
Itano et al., Japan. In Cell Tissue Res, 2008
differential gene expression of microfibril-associated glycoprotein (MAGP-36); MAGP-36 was expressed highly in sites rich in elastic fibers - aorta, skin & esophagus, but it was also expressed highly in other sites containing no elastic fibers.
Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung.
Holmskov et al., Odense, Denmark. In Scand J Immunol, 2006
Microfibrillar associated protein 4 binds pulmonary surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung.
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells.
Lodish et al., Cambridge, United States. In Nat Med, 2006
Furthermore, angiopoietin-like 5, angiopoietin-like 7 and microfibril-associated glycoprotein 4 also supported expansion of HSCs in culture.
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