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Meteorin, glial cell differentiation regulator

Meteorin, METRN
Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: V1a, Glial Fibrillary Acidic Protein, ACID, fibrillin-1, STAT3
Papers on Meteorin
Meteorin is upregulated in reactive astrocytes and functions as a negative feedback effector in reactive gliosis.
Kim et al., Seoul, South Korea. In Mol Med Report, Aug 2015
The aim of the present study was to analyze the expression profile and functions of the astrocytic neurotrophic factor, meteorin, in the progression of reactive gliosis.
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Ulrich et al., Hannover, Germany. In Neuropathol Appl Neurobiol, Apr 2015
The STAT3 pathway was activated using meteorin and inhibited using STAT3 inhibitor VII in the glial progenitor cell line BO-1 and in primary rat OPCs in vitro.
Maternal Serum Meteorin Levels and the Risk of Preeclampsia.
Caminos et al., Bogotá, Colombia. In Plos One, 2014
BACKGROUND: Meteorin (METRN) is a recently described neutrophic factor with angiogenic properties.
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Spiegelman et al., Boston, United States. In Cell, 2014
Using the recently identified isoform of PGC1-α (PGC1-α4) as a discovery tool, we report the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure.
Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.
Miao et al., Shanghai, China. In Cns Neurosci Ther, 2014
Subfatin was annotated as Meteorin-like (Metrnl) in public databases, a similar transcript of Meteorin (Metrn, also known as glial cell differentiation regulator).
Meteorin regulates mesendoderm development by enhancing nodal expression.
Kong et al., Seoul, South Korea. In Plos One, 2013
Here, we show that Meteorin regulates Nodal expression and is required for mesendoderm development.
Meteorin reverses hypersensitivity in rat models of neuropathic pain.
Johansen et al., Ballerup, Denmark. In Exp Neurol, 2012
Here, we investigate the potential therapeutic effect of the neurotrophic factor Meteorin on multiple signs of neuropathic pain in two distinct rat models.
Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.
Lindvall et al., Lund, Sweden. In J Cereb Blood Flow Metab, 2012
Recombinant Metrn infused into the stroke-damaged brain stimulates cell proliferation in subventricular zone, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum.
Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo.
Wahlberg et al., Ballerup, Denmark. In Exp Neurol, 2012
Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family.
Encapsulated cell-based biodelivery of meteorin is neuroprotective in the quinolinic acid rat model of neurodegenerative disease.
Wahlberg et al., Ballerup, Denmark. In Restor Neurol Neurosci, 2011
The purpose of this study was to evaluate EC biodelivery of the novel neurotrophic factor, Meteorin, to the striatum of rats and to investigate its neuroprotective effects against quinolinic acid (QA)-induced excitotoxicity.
Lentiviral delivery of meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model.
Wahlberg et al., Ballerup, Denmark. In Neurobiol Dis, 2011
Meteorin is a newly discovered secreted protein involved in both glial and neuronal cell differentiation, as well as in cerebral angiogenesis during development; but effects in the adult nervous system are unknown.
Meteorin promotes the formation of GFAP-positive glia via activation of the Jak-STAT3 pathway.
Kim et al., Seoul, South Korea. In J Cell Sci, 2010
promotes both cortical stem cell differentiation and retinal glia development via Jak-STAT3 pathway
Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
Takahama et al., Tokushima, Japan. In Plos One, 2009
We found that multiple copies of the human CD3ε transgene are inserted between the Sstr5 and Metrn loci on chromosome 17, and that this is accompanied by duplication of the neighboring genomic region spanning 323 kb.
Characterization of Meteorin--an evolutionary conserved neurotrophic factor.
Wahlberg et al., Ballerup, Denmark. In J Mol Neurosci, 2009
Data show that Meteorin is expressed in the central nervous system both during development and in adult mice.
Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation.
Satoh et al., Tokyo, Japan. In Cell Mol Neurobiol, 2009
The serum elevated the levels of expression of 45 genes, including ID1, ID2, ID3, CTGF, TGFA, METRN, GFAP, CRYAB and CSPG3, whereas it reduced the expression of 23 genes, such as DLL1, DLL3, PDGFRA, SOX4, CSPG4, GAS1 and HES5.
Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension.
Hamada et al., Suita, Japan. In Embo J, 2004
Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis.
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